TY  - JOUR
A1  - Schaeffer, Evelin L.
A1  - Kühn, Franziska
A1  - Schmitt, Angelika
A1  - Gattaz, Wagner F.
A1  - Gruber, Oliver
A1  - Schneider-Axmann, Thomas
A1  - Falkai, Peter
A1  - Schmitt, Andrea
T1  - Increased cell proliferation in the rat anterior cingulate cortex following neonatal hypoxia: relevance to schizophrenia
JF  - Journal of Neural Transmission
N2  - As a consequence of obstetric complications, neonatal hypoxia has been discussed as an environmental factor in the pathophysiology of schizophrenia. However, the biological consequences of hypoxia are unclear. The neurodevelopmental hypothesis of schizophrenia suggests that the onset of abnormal brain development and neuropathology occurs perinatally, whereas symptoms of the disease appear in early adulthood. In our animal model of chronic neonatal hypoxia, we have detected behavioral alterations resembling those known from schizophrenia. Disturbances in cell proliferation possibly contribute to the pathophysiology of this disease. In the present study, we used postnatal rats to investigate cell proliferation in several brain areas following neonatal hypoxia. Rats were repeatedly exposed to hypoxia (89 % N2, 11 % O2) from postnatal day (PD) 4–8. We then evaluated cell proliferation on PD 13 and 39, respectively. These investigations were performed in the anterior cingulate cortex (ACC), caudate-putamen (CPU), dentate gyrus, and subventricular zone. Rats exposed to hypoxia exhibited increased cell proliferation in the ACC at PD 13, normalizing at PD 39. In other brain regions, no alterations have been detected. Additionally, hypoxia-treated rats showed decreased CPU volume at PD 13. The results of the present study on the one hand support the assumption of chronic hypoxia influencing transient cell proliferation in the ACC, and on the other hand reveal normalization during ageing.
KW  - schizophrenia
KW  - cell proliferation
KW  - rat
KW  - anterior cingulate cortex
KW  - neonatal hypoxia
Y1  - 2013
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-125890
VL  - 120
IS  - 1
ER  - 
TY  - JOUR
A1  - Wolter, Steffen
A1  - Aizezers, Janis
A1  - Fennel, Franziska
A1  - Seidel, Marcus
A1  - Würthner, Frank
A1  - Kühn, Oliver
A1  - Lochbrunner, Stefan
T1  - Size-dependent exciton dynamics in one-dimensional perylene bisimide aggregates
JF  - New Journal of Physics
N2  - The size-dependent exciton dynamics of one-dimensional aggregates of substituted perylene bisimides are studied by ultrafast transient absorption spectroscopy and kinetic Monte-Carlo simulations as a function of the excitation density and the temperature in the range of 25-90 degrees C. For low temperatures, the aggregates can be treated as infinite chains and the dynamics is dominated by diffusion-driven exciton-exciton annihilation. With increasing temperature the aggregates dissociate into small fragments consisting of very few monomers. This scenario is also supported by the time-dependent anisotropy deduced from polarization-dependent experiments.
KW  - rotational diffusion
KW  - spectroscopy
KW  - dyes
KW  - annihilation
KW  - migration
KW  - films
Y1  - 2012
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-135190
VL  - 14
IS  - 105027
ER  - 
TY  - JOUR
A1  - Lindhoff-Last, Edelgard
A1  - Birschmann, Ingvild
A1  - Bidenharn, Antonia J.
A1  - Kuhn, Joachim
A1  - Lindau, Simone
A1  - Konstantinides, Stavros
A1  - Grottke, Oliver
A1  - Nowak-Göttl, Ulrike
A1  - Lucks, Jessica
A1  - Zydek, Barbara
A1  - Heymann, Christian von
A1  - Sümnig, Ariane
A1  - Beyer-Westendorf, Jan
A1  - Schellong, Sebastian
A1  - Meybohm, Patrick
A1  - Greinacher, Andreas
A1  - Herrmann, Eva
T1  - Pharmacokinetics of phenprocoumon in emergency situations – results of the prospective observational RADOA-registry (reversal agent use in patients treated with direct oral anticoagulants or vitamin K antagonists registry)
JF  - Pharmaceuticals
N2  - Background: Phenprocoumon has been used as an oral anticoagulant in patients with thromboembolic disease for more than 40 years. So far its pharmacokinetics have not been analyzed in emergency situations. Methods: Phenprocoumon-treated patients with major bleeding or urgent surgery were included in a prospective, observational registry. Phenprocoumon drug concentrations were analyzed in samples, collected as part of routine care using ultraperformance liquid chromatography tandem mass spectrometry. Moreover, anticoagulant intensity and drug half-life (t1/2) were calculated. Results: 115 patients were included. Phenprocoumon levels declined over time with a half-life of 5.27 and 5.29 days in patients with major bleedings (n = 82) and with urgent surgery (n = 33). Baseline phenprocoumon levels were 2.2 times higher in the bleeding group compared to the surgery group (1.92 vs. 0.87 ng/mL, p < 0.0001). International normalized ratio (INR) values decreased rapidly during the first 24 h. In 27.6% of patients a rebound of INR (recurrent increase > 1.5) was observed which was associated with significantly increased bleeding rates (22% vs. 4.2% in patients with or without INR rebound, p = 0.012). Conclusions: In emergency situations, the long half-life of phenprocoumon may cause INR rebound and associated recurrent bleedings. Optimal management may need to include repeated vitamin K supplementation over days.
KW  - phenprocoumon
KW  - pharmacokinetics
KW  - emergency
KW  - major bleeding
KW  - urgent surgery
KW  - INR rebound
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-297226
SN  - 1424-8247
VL  - 15
IS  - 11
ER  -