TY  - JOUR
A1  - Argentiero, Antonella
A1  - Solimando, Antonio Giovanni
A1  - Krebs, Markus
A1  - Leone, Patrizia
A1  - Susca, Nicola
A1  - Brunetti, Oronzo
A1  - Racanelli, Vito
A1  - Vacca, Angelo
A1  - Silvestris, Nicola
T1  - Anti-angiogenesis and immunotherapy: novel paradigms to envision tailored approaches in renal cell-carcinoma
JF  - Journal of Clinical Medicine
N2  - Although decision making strategy based on clinico-histopathological criteria is well established, renal cell carcinoma (RCC) represents a spectrum of biological ecosystems characterized by distinct genetic and molecular alterations, diverse clinical courses and potential specific therapeutic vulnerabilities. Given the plethora of drugs available, the subtype-tailored treatment to RCC subtype holds the potential to improve patient outcome, shrinking treatment-related morbidity and cost. The emerging knowledge of the molecular taxonomy of RCC is evolving, whilst the antiangiogenic and immunotherapy landscape maintains and reinforces their potential. Although several prognostic factors of survival in patients with RCC have been described, no reliable predictive biomarkers of treatment individual sensitivity or resistance have been identified. In this review, we summarize the available evidence able to prompt more precise and individualized patient selection in well-designed clinical trials, covering the unmet need of medical choices in the era of next-generation anti-angiogenesis and immunotherapy.
KW  - renal cell carcinoma
KW  - angiogenesis
KW  - immune-checkpoint inhibitor
KW  - tumor microenvironment
KW  - molecular subtypes
KW  - prognostic-biomarkers
KW  - predictive factors
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-205846
SN  - 2077-0383
VL  - 9
IS  - 5
ER  -