TY  - JOUR
A1  - Lisowski, Dominik
A1  - Trömel, Jannik
A1  - Lutyj, Paul
A1  - Lewitzki, Victor
A1  - Hartrampf, Philipp E.
A1  - Polat, Bülent
A1  - Flentje, Michael
A1  - Tamihardja, Jörg
T1  - Health-related quality of life and clinical outcome after radiotherapy of patients with intracranial meningioma
JF  - Scientific Reports
N2  - This retrospective, single-institutional study investigated long-term outcome, toxicity and health-related quality of life (HRQoL) in meningioma patients after radiotherapy. We analyzed the data of 119 patients who received radiotherapy at our department from 1997 to 2014 for intracranial WHO grade I-III meningioma. Fractionated stereotactic radiotherapy (FSRT), intensity modulated radiotherapy (IMRT) or radiosurgery radiation was applied. The EORTC QLQ-C30 and QLQ-BN20 questionnaires were completed for assessment of HRQoL. Overall survival (OS) for the entire study group was 89.6% at 5 years and 75.9% at 10 years. Local control (LC) at 5 and 10 years was 82.4% and 73.4%, respectively. Local recurrence was observed in 22 patients (18.5%). Higher grade acute and chronic toxicities were observed in seven patients (5.9%) and five patients (4.2%), respectively. Global health status was rated with a mean of 59.9 points (SD 22.3) on QLQ-C30. In conclusion, radiotherapy resulted in very good long-term survival and tumor control rates with low rates of severe toxicities but with a deterioration of long-term HRQoL.
KW  - CNS cancer
KW  - outcomes research
KW  - radiotherapy
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-301233
VL  - 12
ER  -