TY  - JOUR
A1  - Forchert, Leandra
A1  - Potapova, Ekaterina
A1  - Panetta, Valentina
A1  - Dramburg, Stephanie
A1  - Perna, Serena
A1  - Posa, Daniela
A1  - Resch‐Marat, Yvonne
A1  - Lupinek, Christian
A1  - Rohrbach, Alexander
A1  - Grabenhenrich, Linus
A1  - Icke, Katja
A1  - Bauer, Carl‐Peter
A1  - Hoffman, Ute
A1  - Forster, Johannes
A1  - Zepp, Fred
A1  - Schuster, Antje
A1  - Wahn, Ulrich
A1  - Keil, Thomas
A1  - Lau, Susanne
A1  - Vrtala, Susanne
A1  - Valenta, Rudolf
A1  - Matricardi, Paolo Maria
T1  - Der p 23‐specific IgE response throughout childhood and its association with allergic disease: A birth cohort study
JF  - Pediatric Allergy and Immunology
N2  - Background
The Dermatophagoides pteronyssinus molecule Der p 23 is a major allergen whose clinical relevance has been shown in cross‐sectional studies. We longitudinally analysed the trajectory of Der p 23‐specific IgE antibody (sIgE) levels throughout childhood and youth, their early‐life determinants and their clinical relevance for allergic rhinitis and asthma.
Methods
We obtained sera and clinical data of 191 participants of the German Multicentre Allergy Study, a prospective birth cohort. Serum samples from birth to 20 years of age with sIgE reactivity to Der p 23 in a customised semiquantitative microarray were newly analysed with a singleplex quantitative assay. Early mite exposure was assessed by measuring the average content of Der p 1 in house dust at 6 and 18 months.
Results
Der p 23‐sIgE levels were detected at least once in 97/191 participants (51%). Prevalence of Der p 23 sensitisation and mean sIgE levels increased until age 10 years, plateaued until age 13 years and were lowest at age 20 years. Asthma, allergic rhinitis (AR) and atopic dermatitis (AD) were more prevalent in Der p 23‐sensitised children, including those with monomolecular but persistent sensitisation (11/97, 11%). A higher exposure to mites in infancy and occurrence of AD before 5 years of age preceded the onset of Der p 23 sensitisation, which in turn preceded a higher incidence of asthma.
Conclusions
Der p 23 sensitisation peaks in late childhood and then decreases. It is preceded by early mite exposure and AD. Asthma and AR can occur in patients persistently sensitised to Der p 23 as the only mite allergen, suggesting the inclusion of molecular testing of Der p 23‐sIgE for subjects with clinical suspicion of HDM allergy but without sIgE to other major D.pt. allergens.
KW  - asthma
KW  - birth cohort
KW  - childhood
KW  - Der p 23
KW  - house dust mite allergy
KW  - IgE
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-287181
VL  - 33
IS  - 7
ER  - 
TY  - JOUR
A1  - Prantl, Thomas
A1  - Zeck, Timo
A1  - Bauer, Andre
A1  - Ten, Peter
A1  - Prantl, Dominik
A1  - Yahya, Ala Eddine Ben
A1  - Ifflaender, Lukas
A1  - Dmitrienko, Alexandra
A1  - Krupitzer, Christian
A1  - Kounev, Samuel
T1  - A Survey on Secure Group Communication Schemes With Focus on IoT Communication
JF  - IEEE Access
N2  - A key feature for Internet of Things (IoT) is to control what content is available to each user. To handle this access management, encryption schemes can be used. Due to the diverse usage of encryption schemes, there are various realizations of 1-to-1, 1-to-n, and n-to-n schemes in the literature. This multitude of encryption methods with a wide variety of properties presents developers with the challenge of selecting the optimal method for a particular use case, which is further complicated by the fact that there is no overview of existing encryption schemes. To fill this gap, we envision a cryptography encyclopedia providing such an overview of existing encryption schemes. In this survey paper, we take a first step towards such an encyclopedia by creating a sub-encyclopedia for secure group communication (SGC) schemes, which belong to the n-to-n category. We extensively surveyed the state-of-the-art and classified 47 different schemes. More precisely, we provide (i) a comprehensive overview of the relevant security features, (ii) a set of relevant performance metrics, (iii) a classification for secure group communication schemes, and (iv) workflow descriptions of the 47 schemes. Moreover, we perform a detailed performance and security evaluation of the 47 secure group communication schemes. Based on this evaluation, we create a guideline for the selection of secure group communication schemes.
KW  - Internet of Things
KW  - encryption
KW  - secure group communication
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-300257
VL  - 10
SP  - 99944
EP  - 99962
ER  -