TY - JOUR A1 - Albers, Gregory W. A1 - Bernstein, Richard A. A1 - Brachmann, Johannes A1 - Camm, John A1 - Easton, J. Donald A1 - Fromm, Peter A1 - Goto, Shinya A1 - Granger, Christopher B. A1 - Hohnloser, Stefan H. A1 - Hylek, Elaine A1 - Jaffer, Amir K. A1 - Krieger, Derk W. A1 - Passman, Rod A1 - Pines, Jesse M. A1 - Reed, Shelby D. A1 - Rothwell, Peter M. A1 - Kowey, Peter R. T1 - Heart Rhythm Monitoring Strategies for Cryptogenic Stroke: 2015 Diagnostics and Monitoring Stroke Focus Group Report JF - Journal of the American Heart Association N2 - No abstract available. KW - anticoagulants KW - atrial fibrillation KW - diagnosis KW - electrocardiography KW - insertable cardiac monitor KW - stroke prevention Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-165709 VL - 5 IS - e00294 ER - TY - JOUR A1 - Karimi, Sohail M. A1 - Freund, Matthias A1 - Wager, Brittney M. A1 - Knoblauch, Michael A1 - Fromm, Jörg A1 - M. Mueller, Heike A1 - Ache, Peter A1 - Krischke, Markus A1 - Mueller, Martin J. A1 - Müller, Tobias A1 - Dittrich, Marcus A1 - Geilfus, Christoph-Martin A1 - Alfaran, Ahmed H. A1 - Hedrich, Rainer A1 - Deeken, Rosalia T1 - Under salt stress guard cells rewire ion transport and abscisic acid signaling JF - New Phytologist N2 - Soil salinity is an increasingly global problem which hampers plant growth and crop yield. Plant productivity depends on optimal water-use efficiency and photosynthetic capacity balanced by stomatal conductance. Whether and how stomatal behavior contributes to salt sensitivity or tolerance is currently unknown. This work identifies guard cell-specific signaling networks exerted by a salt-sensitive and salt-tolerant plant under ionic and osmotic stress conditions accompanied by increasing NaCl loads. We challenged soil-grown Arabidopsis thaliana and Thellungiella salsuginea plants with short- and long-term salinity stress and monitored genome-wide gene expression and signals of guard cells that determine their function. Arabidopsis plants suffered from both salt regimes and showed reduced stomatal conductance while Thellungiella displayed no obvious stress symptoms. The salt-dependent gene expression changes of guard cells supported the ability of the halophyte to maintain high potassium to sodium ratios and to attenuate the abscisic acid (ABA) signaling pathway which the glycophyte kept activated despite fading ABA concentrations. Our study shows that salinity stress and even the different tolerances are manifested on a single cell level. Halophytic guard cells are less sensitive than glycophytic guard cells, providing opportunities to manipulate stomatal behavior and improve plant productivity. KW - soil KW - stomata KW - abscisic acid (ABA) KW - glycophyte Arabidopsis KW - guard cell KW - halophyte Thellungiella/Eutrema KW - ion transport KW - salt stress Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-259635 VL - 231 IS - 3 ER - TY - JOUR A1 - Johnson, Michael D. A1 - Akiyama, Kazunori A1 - Blackburn, Lindy A1 - Bouman, Katherine L. A1 - Broderick, Avery E. A1 - Cardoso, Vitor A1 - Fender, Rob P. A1 - Fromm, Christian M. A1 - Galison, Peter A1 - Gómez, José L. A1 - Haggard, Daryl A1 - Lister, Matthew L. A1 - Lobanov, Andrei P. A1 - Markoff, Sera A1 - Narayan, Ramesh A1 - Natarajan, Priyamvada A1 - Nichols, Tiffany A1 - Pesce, Dominic W. A1 - Younsi, Ziri A1 - Chael, Andrew A1 - Chatterjee, Koushik A1 - Chaves, Ryan A1 - Doboszewski, Juliusz A1 - Dodson, Richard A1 - Doeleman, Sheperd S. A1 - Elder, Jamee A1 - Fitzpatrick, Garret A1 - Haworth, Kari A1 - Houston, Janice A1 - Issaoun, Sara A1 - Kovalev, Yuri Y. A1 - Levis, Aviad A1 - Lico, Rocco A1 - Marcoci, Alexandru A1 - Martens, Niels C. M. A1 - Nagar, Neil M. A1 - Oppenheimer, Aaron A1 - Palumbo, Daniel C. M. A1 - Ricarte, Angelo A1 - Rioja, María  J. A1 - Roelofs, Freek A1 - Thresher, Ann C. A1 - Tiede, Paul A1 - Weintroub, Jonathan A1 - Wielgus, Maciek T1 - Key science goals for the next-generation Event Horizon Telescope JF - Galaxies N2 - The Event Horizon Telescope (EHT) has led to the first images of a supermassive black hole, revealing the central compact objects in the elliptical galaxy M87 and the Milky Way. Proposed upgrades to this array through the next-generation EHT (ngEHT) program would sharply improve the angular resolution, dynamic range, and temporal coverage of the existing EHT observations. These improvements will uniquely enable a wealth of transformative new discoveries related to black hole science, extending from event-horizon-scale studies of strong gravity to studies of explosive transients to the cosmological growth and influence of supermassive black holes. Here, we present the key science goals for the ngEHT and their associated instrument requirements, both of which have been formulated through a multi-year international effort involving hundreds of scientists worldwide. KW - black holes KW - general relativity KW - interferometry KW - accretion KW - relativistic jets KW - very-long-baseline interferometry KW - EHT KW - ngEHT Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-313525 SN - 2075-4434 VL - 11 IS - 3 ER -