TY  - JOUR
A1  - Kremer, Naomi I.
A1  - Pauwels, Rik W. J.
A1  - Pozzi, Nicolò G.
A1  - Lange, Florian
A1  - Roothans, Jonas
A1  - Volkmann, Jens
A1  - Reich, Martin M.
T1  - Deep Brain Stimulation for Tremor: Update on Long-Term Outcomes, Target Considerations and Future Directions
JF  - Journal of Clinical Medicine
N2  - Deep brain stimulation (DBS) of the thalamic ventral intermediate nucleus is one of the main advanced neurosurgical treatments for drug-resistant tremor. However, not every patient may be eligible for this procedure. Nowadays, various other functional neurosurgical procedures are available. In particular cases, radiofrequency thalamotomy, focused ultrasound and radiosurgery are proven alternatives to DBS. Besides, other DBS targets, such as the posterior subthalamic area (PSA) or the dentato-rubro-thalamic tract (DRT), may be appraised as well. In this review, the clinical characteristics and pathophysiology of tremor syndromes, as well as long-term outcomes of DBS in different targets, will be summarized. The effectiveness and safety of lesioning procedures will be discussed, and an evidence-based clinical treatment approach for patients with drug-resistant tremor will be presented. Lastly, the future directions in the treatment of severe tremor syndromes will be elaborated.
KW  - deep brain stimulation
KW  - tremor
KW  - essential tremor
KW  - Parkinson’s disease
KW  - outcomes
KW  - clinical approach
KW  - target considerations
KW  - future directions
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-244982
SN  - 2077-0383
VL  - 10
IS  - 16
ER  -