TY  - CHAP
A1  - Werner, Rudolf
A1  - Kobayashi, Ryohei
A1  - Wakabayashi, Hiroshi
A1  - Lapa, Constantin
A1  - Menke, Andreas
A1  - Higuchi, Takahiro
T1  - Effect of Antidepressants on Radiolabeled Metaiodobenzylguanidine (MIBG) Uptake
T2  - European Heart Journal - Cardiovascular Imaging
N2  - No abstract available.
KW  - MIBG
KW  - Metaiodobenzylguanidine
KW  - mIBG
KW  - antidepressants
Y1  - 2017
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-161116
SN  - 2047-2404
N1  - This is a pre-copyedited, author-produced version of an article accepted for publication in European Heart Journal Cardiovascular Imaging following peer review. The version of 
record Eur Heart J Cardiovasc Imaging. ISSN: 2047-2404. Supplement, vol. 18, i52-53, May 2017 is available online at: 10.1093/ehjci/jex080.
VL  - 18
IS  - Supplement
PB  - Oxford University Press
ER  - 
TY  - JOUR
A1  - Higuchi, Takahiro
A1  - Serfling, Sebastian E.
A1  - Rowe, Steven P.
A1  - Werner, Rudolf A.
T1  - Therapeutic effects of lipid lowering medications on myocardial blood flow, inflammation, and sympathetic nerve activity using nuclear techniques
JF  - Current Cardiology Reports
N2  - Purpose of Review
Statins are routinely applied in patients with coronary artery disease, as they allow significantly to reduce blood cholesterol levels. Although those drugs are endorsed by current guidelines and prescribed routinely, a substantial portion of patients are still statin-intolerant and image-piloted strategies may then be helpful to identify patients that need further intensified treatment, e.g., to initiate treatment with proprotein convertase subtilisin / kexin type 9 inhibitors (PCSK9i). In addition, it has also been advocated that statins exhibit nonlipid, cardio-protective effects including improved cardiac nerve integrity, blood flow, and anti-inflammatory effects in congestive heart failure (HF) patients.

Recent Findings
In subjects after myocardial infarction treated with statins, \(^{123}\)I-metaiodobenzylguanidine (MIBG) scintigraphy has already revealed enhanced cardiac nerve function relative to patients without statins. In addition, all of those aforementioned statin-targeted pathways in HF can be visualized and monitored using dedicated cardiac radiotracers, e.g., \(^{123}\)I-MIBG or \(^{18}\)F-AF78 (for cardiac nerve function), \(^{18}\)F-flurpiridaz (to determine coronary flow) or \(^{68}\)Ga-PentixaFor (to detect inflammation).

Summary
Statins exhibit various cardio-beneficial effects, including improvement of cardiac nerve function, blood flow, and reduction of inflammation, which can all be imaged using dedicated nuclear cardiac radiotracers. This may allow for in vivo monitoring of statin-induced cardioprotection beyond lipid profiling in HF patients.
KW  - sympathetic nervous system
KW  - cardiac nerve
KW  - MIBG
KW  - inflammation
KW  - blood flow
KW  - statin
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-324599
VL  - 24
IS  - 12
ER  -