TY  - JOUR
A1  - Kaireit, Till F.
A1  - Sorrentino, Sajoscha A.
A1  - Renne, Julius
A1  - Schoenfeld, Christian
A1  - Voskrebenzev, Andreas
A1  - Gutberlet, Marcel
A1  - Schulz, Angela
A1  - Jakob, Peter M.
A1  - Hansen, Gesine
A1  - Wacker, Frank
A1  - Welte, Tobias
A1  - Tümmler, Burkhard
A1  - Vogel-Claussen, Jens
T1  - Functional lung MRI for regional monitoring of patients with cystic fibrosis
JF  - PLoS ONE
N2  - Purpose
To test quantitative functional lung MRI techniques in young adults with cystic fibrosis (CF) compared to healthy volunteers and to monitor immediate treatment effects of a single inhalation of hypertonic saline in comparison to clinical routine pulmonary function tests.

Materials and methods
Sixteen clinically stable CF patients and 12 healthy volunteers prospectively underwent two functional lung MRI scans and pulmonary function tests before and 2h after a single treatment of inhaled hypertonic saline or without any treatment. MRI-derived oxygen enhanced T1 relaxation measurements, fractional ventilation, first-pass perfusion parameters and a morpho-functional CF-MRI score were acquired.

Results
Compared to healthy controls functional lung MRI detected and quantified significantly increased ventilation heterogeneity in CF patients. Regional functional lung MRI measures of ventilation and perfusion as well as the CF-MRI score and pulmonary function tests could not detect a significant treatment effect two hours after a single treatment with hypertonic saline in young adults with CF (p>0.05).

Conclusion
This study shows the feasibility of functional lung MRI as a non-invasive, radiation-free tool for monitoring patients with CF.
KW  - Physics
KW  - Magnetic resonance imaging
KW  - Functional magnetic resonance imaging
KW  - Cystic fibrosis
KW  - Oxygen
KW  - Pulmonary imaging
KW  - Hypertonic
KW  - Pulmonary function
KW  - Quantum chronodynamics
Y1  - 2017
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-172457
VL  - 12
IS  - 12
ER  -