TY  - JOUR
A1  - Haack, Stephanie
A1  - Baiker, Sarah
A1  - Schlegel, Jan
A1  - Sauer, Markus
A1  - Sparwasser, Tim
A1  - Langenhorst, Daniela
A1  - Beyersdorf, Niklas
T1  - Superagonistic CD28 stimulation induces IFN‐γ release from mouse T helper 1 cells in vitro and in vivo
JF  - European Journal of Immunology
N2  - Like human Th1 cells, mouse Th1 cells also secrete IFN‐γ upon stimulation with a superagonistic anti‐CD28 monoclonal antibody (CD28‐SA). Crosslinking of the CD28‐SA via FcR and CD40‐CD40L interactions greatly increased IFN‐γ release. Our data stress the utility of the mouse as a model organism for immune responses in humans.
KW  - CD28
KW  - Th1 cells
KW  - cytokine release
KW  - interferon γ
KW  - Superagonistic antibody
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-239028
VL  - 51
IS  - 3
SP  - 738
EP  - 741
ER  -