TY  - JOUR
A1  - Colunga, Thomas
A1  - Hayworth, Miranda
A1  - Kreß, Sebastian
A1  - Reynolds, David M.
A1  - Chen, Luoman
A1  - Nazor, Kristopher L.
A1  - Baur, Johannes
A1  - Singh, Amar M.
A1  - Loring, Jeanne F.
A1  - Metzger, Marco
A1  - Dalton, Stephen
T1  - Human Pluripotent Stem Cell-Derived Multipotent Vascular Progenitors of the Mesothelium Lineage Have Utility in Tissue Engineering and Repair
JF  - Cell Reports
N2  - In this report we describe a human pluripotent stem cell-derived vascular progenitor (MesoT) cell of the mesothelium lineage. MesoT cells are multipotent and generate smooth muscle cells, endothelial cells, and pericytes and self-assemble into vessel-like networks in vitro. MesoT cells transplanted into mechanically damaged neonatal mouse heart migrate into the injured tissue and contribute to nascent coronary vessels in the repair zone. When seeded onto decellularized vascular scaffolds, MesoT cells differentiate into the major vascular lineages and self-assemble into vasculature capable of supporting peripheral blood flow following transplantation. These findings demonstrate in vivo functionality and the potential utility of MesoT cells in vascular engineering applications.
KW  - stem cells
KW  - mesothelium
KW  - vascular progenitor
KW  - tissue engineering
KW  - regenerative medicine
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-223217
VL  - 26
ER  -