TY  - JOUR
A1  - Reusch, Julia
A1  - Wagenhäuser, Isabell
A1  - Gabel, Alexander
A1  - Eggestein, Annika
A1  - Höhn, Anna
A1  - Lâm, Thiên-Trí
A1  - Frey, Anna
A1  - Schubert-Unkmeir, Alexandra
A1  - Dölken, Lars
A1  - Frantz, Stefan
A1  - Kurzai, Oliver
A1  - Vogel, Ulrich
A1  - Krone, Manuel
A1  - Petri, Nils
T1  - Influencing factors of anti-SARS-CoV-2-spike-IgG antibody titers in healthcare workers: A cross-section study
JF  - Journal of Medical Virology
N2  - Against the background of the current COVID-19 infection dynamics with its rapid spread of SARS-CoV-2 variants of concern (VOC), the immunity and the vaccine prevention of healthcare workers (HCWs) against SARS-CoV-2 continues to be of high importance. This observational cross-section study assesses factors influencing the level of anti-SARS-CoV-2-spike IgG after SARS-CoV-2 infection or vaccination. One thousand seven hundred and fifty HCWs were recruited meeting the following inclusion criteria: age ≥18 years, PCR-confirmed SARS-CoV-2 infection convalescence and/or at least one dose of COVID-19 vaccination. anti-SARS-CoV-2-spike IgG titers were determined by SERION ELISA agile SARS-CoV-2 IgG. Mean anti-SARS-CoV-2-spike IgG levels increased significantly by number of COVID-19 vaccinations (92.2 BAU/ml for single, 140.9 BAU/ml for twice and 1144.3 BAU/ml for threefold vaccination). Hybrid COVID-19 immunized respondents (after infection and vaccination) had significantly higher antibody titers compared with convalescent only HCWs. Anti-SARS-CoV-2-spike IgG titers declined significantly with time after the second vaccination. Smoking and high age were associated with lower titers. Both recovered and vaccinated HCWs presented a predominantly good humoral immune response. Smoking and higher age limited the humoral SARS-CoV-2 immunity, adding to the risk of severe infections within this already health impaired collective.
KW  - anti‐SARS‐CoV‐2‐spike IgG
KW  - seroprevalence
KW  - SARS‐CoV‐2 infection
KW  - healthcare workers
KW  - COVID‐19 vaccination
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-318659
VL  - 95
IS  - 1
ER  -