TY  - JOUR
A1  - Abboud, Tammam
A1  - Asendorf, Thomas
A1  - Heinrich, Jutta
A1  - Faust, Katharina
A1  - Krieg, Sandro M.
A1  - Seidel, Kathleen
A1  - Mielke, Dorothee
A1  - Matthies, Cordola
A1  - Ringel, Florian
A1  - Rohde, Veit
A1  - Szelényi, Andrea
T1  - Transcranial versus direct cortical stimulation for motor-evoked potentials during resection of supratentorial tumors under general anesthesia (the TRANSEKT-trial): study protocol for a randomized controlled trial
JF  - Biomedicines
N2  - Background: Monitoring of motor function during surgery for supratentorial tumors under general anesthesia applies either transcranial electrical stimulation (TES) or direct cortical stimulation (DCS) to elicit motor-evoked potentials. To date, there is no guideline that favor one method over the other. Therefore, we designed this randomized study to compare between both methods regarding the prediction of postoperative motor deficits and extent of tumor resection. Methods: This is a multicenter (six centers in Germany and one in Switzerland), double blind, parallel group, exploratory, randomized controlled clinical trial. Patients without or with mild paresis, who are scheduled for surgical resection of motor-eloquent brain tumors under general anesthesia will be randomized to surgical resection under TES or surgical resection under DCS. The primary endpoint is sensitivity and specificity in prognosis of motor function 7 days after surgery. The main secondary endpoint is the extent of tumor resection. The study is planned to include 120 patients within 2 years. Discussion: The present exploratory study should compare TES and DCS regarding sensitivity and specificity in predicting postoperative motor deficit and extent of tumor resection to calculate the required number of patients in a confirmatory trial to test the superiority of one method over the other.
KW  - threshold criterion
KW  - amplitude criterion
KW  - intraoperative monitoring
KW  - transcranial motor-evoked potentials
KW  - direct cortical stimulation
KW  - threshold level
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-248513
SN  - 2227-9059
VL  - 9
IS  - 10
ER  - 
TY  - JOUR
A1  - Fröhlich, Ellen
A1  - Sassenrath, Claudia
A1  - Nadji-Ohl, Minou
A1  - Unteroberdörster, Meike
A1  - Rückriegel, Stefan
A1  - Brelie, Christian von der
A1  - Roder, Constantin
A1  - Forster, Marie-Therese
A1  - Schommer, Stephan
A1  - Löhr, Mario
A1  - Pala, Andrej
A1  - Goebel, Simone
A1  - Mielke, Dorothee
A1  - Gerlach, Rüdiger
A1  - Renovanz, Mirjam
A1  - Wirtz, Christian Rainer
A1  - Onken, Julia
A1  - Czabanka, Marcus
A1  - Tatagiba, Marcos Soares
A1  - Rohde, Veit
A1  - Ernestus, Ralf-Ingo
A1  - Vajkoczy, Peter
A1  - Gansland, Oliver
A1  - Coburger, Jan
T1  - Resilience in lower grade glioma patients
JF  - Cancers
N2  - Current data show that resilience is an important factor in cancer patients’ well-being. We aim to explore the resilience of patients with lower grade glioma (LGG) and the potentially influencing factors. We performed a cross-sectional assessment of adult patients with LGG who were enrolled in the LoG-Glio registry. By phone interview, we administered the following measures: Resilience Scale (RS-13), distress thermometer, Montreal Cognitive Assessment Test for visually impaired patients (MoCA-Blind), internalized stigmatization by brain tumor (ISBI), Eastern Cooperative Oncological Group performance status (ECOG), patients’ perspective questionnaire (PPQ) and typical clinical parameters. We calculated correlations and multivariate regression models. Of 74 patients who were assessed, 38% of those showed a low level of resilience. Our results revealed significant correlations of resilience with distress (p < 0.001, −0.49), MOCA (p = 0.003, 0.342), ECOG (p < 0.001, −0.602), stigmatization (p < 0.001, −0.558), pain (p < 0.001, −0.524), and occupation (p = 0.007, 0.329). In multivariate analyses, resilience was negatively associated with elevated ECOG (p = 0.020, β = −0.383) and stigmatization levels (p = 0.008, β = −0.350). Occupation showed a tendency towards a significant association with resilience (p = 0.088, β = −0.254). Overall, low resilience affected more than one third of our cohort. Low functional status is a specific risk factor for low resilience. The relevant influence of stigmatization on resilience is a novel finding for patients suffering from a glioma and should be routinely identified and targeted in clinical routine.
KW  - resilience
KW  - lower grade glioma
KW  - diffuse astrocytoma
KW  - oligodendroglioma
KW  - RS-13
KW  - distress
KW  - internalized stigmatization
KW  - ISBI
KW  - occupation
KW  - pain
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-297518
SN  - 2072-6694
VL  - 14
IS  - 21
ER  -