TY  - JOUR
A1  - Kleefeldt, Florian
A1  - Bömmel, Heike
A1  - Broede, Britta
A1  - Thomsen, Michael
A1  - Pfeiffer, Verena
A1  - Wörsdörfer, Philipp
A1  - Karnati, Srikanth
A1  - Wagner, Nicole
A1  - Rueckschloss, Uwe
A1  - Ergün, Süleyman
T1  - Aging‐related carcinoembryonic antigen‐related cell adhesion molecule 1 signaling promotes vascular dysfunction
JF  - Aging Cell
N2  - Aging is an independent risk factor for cardiovascular diseases and therefore of particular interest for the prevention of cardiovascular events. However, the mechanisms underlying vascular aging are not well understood. Since carcinoembryonic antigen‐related cell adhesion molecule 1 (CEACAM1) is crucially involved in vascular homeostasis, we sought to identify the role of CEACAM1 in vascular aging. Using human internal thoracic artery and murine aorta, we show that CEACAM1 is upregulated in the course of vascular aging. Further analyses demonstrated that TNF‐α is CEACAM1‐dependently upregulated in the aging vasculature. Vice versa, TNF‐α induces CEACAM1 expression. This results in a feed‐forward loop in the aging vasculature that maintains a chronic pro‐inflammatory milieu. Furthermore, we demonstrate that age‐associated vascular alterations, that is, increased oxidative stress and vascular fibrosis, due to increased medial collagen deposition crucially depend on the presence of CEACAM1. Additionally, age‐dependent upregulation of vascular CEACAM1 expression contributes to endothelial barrier impairment, putatively via increased VEGF/VEGFR‐2 signaling. Consequently, aging‐related upregulation of vascular CEACAM1 expression results in endothelial dysfunction that may promote atherosclerotic plaque formation in the presence of additional risk factors. Our data suggest that CEACAM1 might represent an attractive target in order to delay physiological aging and therefore the transition to vascular disorders such as atherosclerosis.
KW  - aging
KW  - anti‐aging
KW  - cytokines
KW  - inflammation
KW  - mouse
KW  - reactive oxygen species
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-201231
VL  - 2019
IS  - 18
ER  - 
TY  - JOUR
A1  - Götz, Lisa
A1  - Rueckschloss, Uwe
A1  - Balk, Gözde
A1  - Pfeiffer, Verena
A1  - Ergün, Süleyman
A1  - Kleefeldt, Florian
T1  - The role of carcinoembryonic antigen-related cell adhesion molecule 1 in cancer
JF  - Frontiers in Immunology
N2  - The Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), also known as CD66a, is a member of the immunoglobulin superfamily. CEACAM1 was shown to be a prognostic marker in patients suffering from cancer. In this review, we summarize pre-clinical and clinical evidence linking CEACAM1 to tumorigenicity and cancer progression. Furthermore, we discuss potential CEACAM1-based mechanisms that may affect cancer biology.
KW  - CEACAM1
KW  - CEA
KW  - cancer
KW  - tumor
KW  - malignancy
KW  - metastasis
KW  - signaling
Y1  - 2023
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-357250
VL  - 14
ER  -