TY  - THES
A1  - Szewczykowski, Viktoria
T1  - Definitionen und Diagnostika der periprothetischen Infektion
T1  - Definitions and diagnostics of the periprosthetic joint infection
N2  - Die periprothetische Infektion (PPI) ist eine seltene aber schwerwiegende Komplikation nach Implantation einer Hüftprothese. Diese Arbeit hat verschiedene Aspekte bezüglich der Diagnostik und Definition der PPI untersucht. Der primäre Fokus lag auf der mikrobiologischen Punktionsdiagnostik und seiner Korrelation mit mikrobiologischen Befunden aus intraoperativen Proben. Zudem war die Gegenüberstellung der verschiedenen Definitionen einer PPI ein weiterer Schwerpunkt der Arbeit. Des Weiteren wurden auch einige weitere Untersuchungsparameter der PPI untersucht und gegenübergestellt.
N2  - The periprosthetic joint infection (PJI) is a rare but serious complication occurring after the implantation of a hip prosthesis. This work has investigated various aspects regarding the diagnosis and definition of PJI. The primary focus was on microbiological preoperative aspiration analysis and its correlation with microbiological findings from intraoperative tissue samples. In addition, the comparison of different definitions of PJI constituted another focus of this work. Furthermore, some other examination parameters of PJI were also investigated and compared.
KW  - periprothetische Infektion
Y1  - 2023
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-299327
ER  - 
TY  - JOUR
A1  - Boelch, Sebastian Philipp
A1  - Rüeckl, Kilian
A1  - Streck, Laura Elisa
A1  - Szewczykowski, Viktoria
A1  - Weißenberger, Manuel
A1  - Jakuscheit, Axel
A1  - Rudert, Maximilian
T1  - Diagnosis of chronic infection at total hip arthroplasty revision is a question of definition
JF  - Biomed Research International
N2  - Purpose. Contradicting definitions of periprosthetic joint infection (PJI) are in use. Joint aspiration is performed before total hip arthroplasty (THA) revision. This study investigated the influence of PJI definition on PJI prevalence at THA revision. Test quality of prerevision aspiration was evaluated for the different PJI definitions. Methods. 256 THA revisions were retrospectively classified to be infected or not infected. Classification was performed according to the 4 different definitions proposed by the Musculoskeletal Infection Society (MSIS), the Infectious Diseases Society of America (IDSA), the International Consensus Meeting (ICM), and the European Bone and Joint Infection Society (EBJIS). Only chronic PJIs were included. Results. PJI prevalence at revision significantly correlated with the applied PJI definition (p=0.01, Cramer's V=0.093). PJI prevalence was 20.7% for the MSIS, 25.4% for the ICM, 28.1% for the IDSA, and 32.0% for the EBJIS definition. For synovial fluid white blood cell count, the best ROC-AUC for predicting PJI was 0.953 in combination with the MSIS definition. Conclusion. PJI definition significantly influences the rate of diagnosed PJIs at THA revision. Synovial fluid white blood cell count is a reliable means to rule out PJI. In cases with a borderline high synovial white blood cell count before THA revision as the only sign of chronic PJI, an extended diagnostic work-up should be considered.
KW  - periprosthetic joint infection
KW  - algorithm
KW  - consensus
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-265762
VL  - 2021
ER  -