TY  - JOUR
A1  - Kunzmann, Volker
A1  - Herrmann, Ken
A1  - Bluemel, Christina
A1  - Kapp, Markus
A1  - Hartlapp, Ingo
A1  - Steger, Ulrich
T1  - Intensified neoadjuvant chemotherapy with nab-paclitaxel plus gemcitabine followed by FOLFIRINOX in a patient with locally advanced unresectable pancreatic cancer
JF  - Case Reports in Oncology
N2  - The prognosis of patients with locally advanced pancreatic cancer can be improved if secondary complete (R0) resection is possible. In patients initially staged as unresectable this may be achieved with neoadjuvant treatment which is usually chemoradiotherapy based. We report the case of a 46-year-old patient with an unresectable, locally advanced pancreatic cancer (pT4 Nx cM0 G2) who was treated with a sequential neoadjuvant chemotherapy regimen consisting of 2 cycles of nab-paclitaxel plus gemcitabine followed by 4 cycles of FOLFIRINOX. Neoadjuvant chemotherapy resulted in secondary resectability (R0 resection). After 2 cycles of nab-paclitaxel plus gemcitabine, the patient already had a complete metabolic remission as measured by integrated fludeoxyglucose ((18)F) positron emission tomography and computerized tomography. After a follow-up of 18 months the patient is alive without progression of disease. We propose to assess the clinical benefit of sequencing the combinations nab-paclitaxel plus gemcitabine and FOLFIRINOX as neoadjuvant therapy for patients with locally advanced and initially unresectable pancreatic cancer in a controlled clinical trial.
KW  - nab-paclitaxel
KW  - neoadjuvant chemotherapy
KW  - oxaliplatin
KW  - pancreatic cancer
KW  - locally advanced disease
KW  - irinotecan
KW  - gemcitabine
KW  - folinic acid
KW  - 5-Fluorouracil
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-120189
SN  - 1662-6575
VL  - 7
IS  - 3
ER  -