TY - THES A1 - Mäder, Andreas T1 - Performance Models for UMTS 3.5G Mobile Wireless Systems T1 - Leistungsmodelle für UMTS 3.5G Mobilfunksysteme N2 - Mobile telecommunication systems of the 3.5th generation (3.5G) constitute a first step towards the requirements of an all-IP world. As the denotation suggests, 3.5G systems are not completely new designed from scratch. Instead, they are evolved from existing 3G systems like UMTS or cdma2000. 3.5G systems are primarily designed and optimized for packet-switched best-effort traffic, but they are also intended to increase system capacity by exploiting available radio resources more efficiently. Systems based on cdma2000 are enhanced with 1xEV-DO (EV-DO: evolution, data-optimized). In the UMTS domain, the 3G partnership project (3GPP) specified the High Speed Packet Access (HSPA) family, consisting of High Speed Downlink Packet Access (HSDPA) and its counterpart High Speed Uplink Packet Access (HSUPA) or Enhanced Uplink. The focus of this monograph is on HSPA systems, although the operation principles of other 3.5G systems are similar. One of the main contributions of our work are performance models which allow a holistic view on the system. The models consider user traffic on flow-level, such that only on significant changes of the system state a recalculation of parameters like bandwidth is necessary. The impact of lower layers is captured by stochastic models. This approach combines accurate modeling and the ability to cope with computational complexity. Adopting this approach to HSDPA, we develop a new physical layer abstraction model that takes radio resources, scheduling discipline, radio propagation and mobile device capabilities into account. Together with models for the calculation of network-wide interference and transmit powers, a discrete-event simulation and an analytical model based on a queuing-theoretical approach are proposed. For the Enhanced Uplink, we develop analytical models considering independent and correlated other-cell interference. N2 - Die vorliegende Arbeit beschäftigt sich mit Mobilfunksystemen der Generation 3.5 im Allgemeinen, und mit den UMTS-spezifischen Ausprägungen HSDPA (High Speed Downlink Packet Access) und HSUPA (High Speed Uplink Packet Access) bzw. Enhanced Uplink im speziellen. Es werden integrierte Systeme betrachtet, d.h. 3.5G Datenkanäle koexistieren mit "klassischen" UMTS Datenkanälen wie in den Spezifikationen von UMTS Release ´99 beschrieben. T3 - Würzburger Beiträge zur Leistungsbewertung Verteilter Systeme - 02/08 KW - Mobilfunk KW - Leistungsbewertung KW - UMTS KW - HSPA KW - Funkressourcenverwaltung KW - Modellierungstechniken KW - Netzwerkplanung KW - UMTS KW - HSPA KW - radio resource management KW - modeling techniques KW - network planning Y1 - 2008 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-32525 ER - TY - THES A1 - Pries, Jan Rastin T1 - Performance Optimization of Wireless Infrastructure and Mesh Networks T1 - Leistungsoptimierung von drahtlosen Infrastruktur und Mesh Netzen N2 - Future broadband wireless networks should be able to support not only best effort traffic but also real-time traffic with strict Quality of Service (QoS) constraints. In addition, their available resources are scare and limit the number of users. To facilitate QoS guarantees and increase the maximum number of concurrent users, wireless networks require careful planning and optimization. In this monograph, we studied three aspects of performance optimization in wireless networks: resource optimization in WLAN infrastructure networks, quality of experience control in wireless mesh networks, and planning and optimization of wireless mesh networks. An adaptive resource management system is required to effectively utilize the limited resources on the air interface and to guarantee QoS for real-time applications. Thereby, both WLAN infrastructure and WLAN mesh networks have to be considered. An a-priori setting of the access parameters is not meaningful due to the contention-based medium access and the high dynamics of the system. Thus, a management system is required which dynamically adjusts the channel access parameters based on the network load. While this is sufficient for wireless infrastructure networks, interferences on neighboring paths and self-interferences have to be considered for wireless mesh networks. In addition, a careful channel allocation and route assignment is needed. Due to the large parameter space, standard optimization techniques fail for optimizing large wireless mesh networks. In this monograph, we reveal that biology-inspired optimization techniques, namely genetic algorithms, are well-suitable for the planning and optimization of wireless mesh networks. Although genetic algorithms generally do not always find the optimal solution, we show that with a good parameter set for the genetic algorithm, the overall throughput of the wireless mesh network can be significantly improved while still sharing the resources fairly among the users. N2 - Die Anbindung an das Internet erfolgt zunehmend über drahtlose Netze. Deren Ressourcen sind allerdings limitiert, was die Anzahl der unterstützten Nutzer stark einschränkt. Zudem ist ein Trend dieser Nutzer weg von der Verwendung reiner Datendienste zu Diensten mit Echtzeitanforderungen wie Voice over IP (VoIP) zu erkennen, deren Dienstgüteanforderungen eingehalten werden müssen. Heutige drahtlose Zugangsnetze sind jedoch nur für den herkömmlichen Datenverkehr ausgelegt. Der IEEE 802.11 WLAN Standard unterscheidet zwar zwischen verschiedenen Dienstklassen, gibt aber keine Dienstgütegarantien. Um die Dienstgüte (Quality of Service, QoS), bzw. die vom Nutzer erfahrene Dienstgüte (Quality of Experience, QoE) zu garantieren, müssen die zukünftigen drahtlosen Netze daher sorgfältig geplant und optimiert werden. Um die limitierten Ressourcen auf der Luftschnittstelle effektiv zu nutzen und um Dienstgüteanforderungen für Echtzeitanwendungen einzuhalten, bedarf es eines adaptiven Ressourcenmanagements. Dabei sind sowohl drahtlose Infrastruktur, als auch drahtlose Mesh-Netze zu betrachten. Durch den randomisierten Medienzugriff und die hohe Dynamik im System ist eine a-priori Wahl der Zugangsparameter nicht sinnvoll. Vielmehr wird ein Managementsystem benötigt, das die Zugangsparameter dynamisch in Abhängigkeit der Last in einem Netz wählt. Während dies für drahtlose Infrastrukturnetze ausreicht, müssen in drahtlosen Mesh-Netzen zusätzlich noch Interferenzen von Nachbarpfaden und Eigeninterferenzen berücksichtigt werden. Desweiteren ist eine sorgfältige Planung der Kanalzuweisung und des Routings notwendig, um einerseits den Durchsatz in drahtlosen Mesh-Netzen zu maximieren und andererseits die Ressourcen fair zwischen den Stationen aufzuteilen. Da es dabei eine Vielzahl von Parametern zu berücksichtigen gilt, sind neue Optimierungsmethoden notwendig, die es ermöglichen, auch große Mesh-Netze in annehmbarer Zeit zu planen und zu optimieren. Diese Doktorarbeit arbeitet die folgenden drei Optimierungsmöglichkeiten für drahtlose Zugangsnetze aus: Optimierung der Zugangsparameter in drahtlosen Infrastrukturnetzen, Optimierung von drahtlosen Mesh-Netzen unter Berücksichtigung der QoE und Planung und Optimierung von drahtlosen Mesh-Netzen mit Berücksichtigung einer fairen Ressourcenallokation. Die Ergebnisse und Untersuchungen dieser Arbeit gliedern sich entsprechend dieser Optimierungsmöglichkeiten. T3 - Würzburger Beiträge zur Leistungsbewertung Verteilter Systeme - 01/10 KW - IEEE 802.11 KW - Leistungsbewertung KW - Optimierung KW - Dienstgüte KW - Netzplanung KW - Drahtloses lokales Netz KW - WLAN KW - Mesh Netze KW - Genetische Optimierung KW - WLAN KW - Optimization KW - Mesh Networks KW - Genetic Optimization Y1 - 2010 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-46097 ER - TY - INPR A1 - Nassourou, Mohamadou T1 - Philosophical and Computational Approaches for Estimating and Visualizing Months of Revelations of Quranic Chapters N2 - The question of why the Quran structure does not follow its chronology of revelation is a recurring one. Some Islamic scholars such as [1] have answered the question using hadiths, as well as other philosophical reasons based on internal evidences of the Quran itself. Unfortunately till today many are still wondering about this issue. Muslims believe that the Quran is a summary and a copy of the content of a preserved tablet called Lawhul-Mahfuz located in the heaven. Logically speaking, this suggests that the arrangement of the verses and chapters is expected to be similar to that of the Lawhul-Mahfuz. As for the arrangement of the verses in each chapter, there is unanimity that it was carried out by the Prophet himself under the guidance of Angel Gabriel with the recommendation of God. But concerning the ordering of the chapters, there are reports about some divergences [3] among the Prophet’s companions as to which chapter should precede which one. This paper argues that Quranic chapters might have been arranged according to months and seasons of revelation. In fact, based on some verses of the Quran, it is defendable that the Lawhul-Mahfuz itself is understood to have been structured in terms of the months of the year. In this study, philosophical and mathematical arguments for computing chapters’ months of revelation are discussed, and the result is displayed on an interactive scatter plot. KW - Text Mining KW - Visualisierung KW - Koran KW - Text mining KW - Visualization KW - Chronology of revelation KW - Chapters arrangement KW - Quran KW - Lawhul-Mahfuz Y1 - 2011 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-65784 ER - TY - CHAP ED - von Mammen, Sebastian ED - Klemke, Roland ED - Lorber, Martin T1 - Proceedings of the 1st Games Technology Summit BT - part of Clash of Realites 11th International Conference on the Technology and Theory of Digital Games N2 - As part of the Clash of Realities International Conference on the Technology and Theory of Digital Games, the Game Technology Summit is a premium venue to bring together experts from academia and industry to disseminate state-of-the-art research on trending technology topics in digital games. In this first iteration of the Game Technology Summit, we specifically paid attention on how the successes in AI in Natural User Interfaces have been impacting the games industry (industry track) and which scientific, state-of-the-art ideas and approaches are currently pursued (scientific track). KW - Veranstaltung KW - Künstliche Intelligenz KW - Mensch-Maschine-Kommunikation KW - Computerspiel KW - natural user interfaces KW - artificial intelligence Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-245776 SN - 978-3-945459-36-2 ER - TY - JOUR A1 - Kammerer, Klaus A1 - Pryss, Rüdiger A1 - Hoppenstedt, Burkhard A1 - Sommer, Kevin A1 - Reichert, Manfred T1 - Process-driven and flow-based processing of industrial sensor data JF - Sensors N2 - For machine manufacturing companies, besides the production of high quality and reliable machines, requirements have emerged to maintain machine-related aspects through digital services. The development of such services in the field of the Industrial Internet of Things (IIoT) is dealing with solutions such as effective condition monitoring and predictive maintenance. However, appropriate data sources are needed on which digital services can be technically based. As many powerful and cheap sensors have been introduced over the last years, their integration into complex machines is promising for developing digital services for various scenarios. It is apparent that for components handling recorded data of these sensors they must usually deal with large amounts of data. In particular, the labeling of raw sensor data must be furthered by a technical solution. To deal with these data handling challenges in a generic way, a sensor processing pipeline (SPP) was developed, which provides effective methods to capture, process, store, and visualize raw sensor data based on a processing chain. Based on the example of a machine manufacturing company, the SPP approach is presented in this work. For the company involved, the approach has revealed promising results. KW - data stream processing KW - cyber-physical systems KW - processing pipeline KW - sensor networks Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-213089 SN - 1424-8220 VL - 20 IS - 18 ER - TY - JOUR A1 - Caliskan, Aylin A1 - Crouch, Samantha A. W. A1 - Giddins, Sara A1 - Dandekar, Thomas A1 - Dangwal, Seema T1 - Progeria and aging — Omics based comparative analysis JF - Biomedicines N2 - Since ancient times aging has also been regarded as a disease, and humankind has always strived to extend the natural lifespan. Analyzing the genes involved in aging and disease allows for finding important indicators and biological markers for pathologies and possible therapeutic targets. An example of the use of omics technologies is the research regarding aging and the rare and fatal premature aging syndrome progeria (Hutchinson-Gilford progeria syndrome, HGPS). In our study, we focused on the in silico analysis of differentially expressed genes (DEGs) in progeria and aging, using a publicly available RNA-Seq dataset (GEO dataset GSE113957) and a variety of bioinformatics tools. Despite the GSE113957 RNA-Seq dataset being well-known and frequently analyzed, the RNA-Seq data shared by Fleischer et al. is far from exhausted and reusing and repurposing the data still reveals new insights. By analyzing the literature citing the use of the dataset and subsequently conducting a comparative analysis comparing the RNA-Seq data analyses of different subsets of the dataset (healthy children, nonagenarians and progeria patients), we identified several genes involved in both natural aging and progeria (KRT8, KRT18, ACKR4, CCL2, UCP2, ADAMTS15, ACTN4P1, WNT16, IGFBP2). Further analyzing these genes and the pathways involved indicated their possible roles in aging, suggesting the need for further in vitro and in vivo research. In this paper, we (1) compare “normal aging” (nonagenarians vs. healthy children) and progeria (HGPS patients vs. healthy children), (2) enlist genes possibly involved in both the natural aging process and progeria, including the first mention of IGFBP2 in progeria, (3) predict miRNAs and interactomes for WNT16 (hsa-mir-181a-5p), UCP2 (hsa-mir-26a-5p and hsa-mir-124-3p), and IGFBP2 (hsa-mir-124-3p, hsa-mir-126-3p, and hsa-mir-27b-3p), (4) demonstrate the compatibility of well-established R packages for RNA-Seq analysis for researchers interested but not yet familiar with this kind of analysis, and (5) present comparative proteomics analyses to show an association between our RNA-Seq data analyses and corresponding changes in protein expression. KW - progeria KW - aging KW - omics KW - RNA sequencing KW - bioinformatics KW - sun exposure KW - HGPS KW - IGFBP2 KW - ACKR4 KW - WNT Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-289868 SN - 2227-9059 VL - 10 IS - 10 ER - TY - THES A1 - Huber, Stephan T1 - Proxemo: Documenting Observed Emotions in HCI T1 - Proxemo: Die Dokumentation Beobachteter Emotionen in der Mensch-Computer-Interaktion N2 - For formative evaluations of user experience (UX) a variety of methods have been developed over the years. However, most techniques require the users to interact with the study as a secondary task. This active involvement in the evaluation is not inclusive of all users and potentially biases the experience currently being studied. Yet there is a lack of methods for situations in which the user has no spare cognitive resources. This condition occurs when 1) users' cognitive abilities are impaired (e.g., people with dementia) or 2) users are confronted with very demanding tasks (e.g., air traffic controllers). In this work we focus on emotions as a key component of UX and propose the new structured observation method Proxemo for formative UX evaluations. Proxemo allows qualified observers to document users' emotions by proxy in real time and then directly link them to triggers. Technically this is achieved by synchronising the timestamps of emotions documented by observers with a video recording of the interaction. In order to facilitate the documentation of observed emotions in highly diverse contexts we conceptualise and implement two separate versions of a documentation aid named Proxemo App. For formative UX evaluations of technology-supported reminiscence sessions with people with dementia, we create a smartwatch app to discreetly document emotions from the categories anger, general alertness, pleasure, wistfulness and pride. For formative UX evaluations of prototypical user interfaces with air traffic controllers we create a smartphone app to efficiently document emotions from the categories anger, boredom, surprise, stress and pride. Descriptive case studies in both application domains indicate the feasibility and utility of the method Proxemo and the appropriateness of the respectively adapted design of the Proxemo App. The third part of this work is a series of meta-evaluation studies to determine quality criteria of Proxemo. We evaluate Proxemo regarding its reliability, validity, thoroughness and effectiveness, and compare Proxemo's efficiency and the observers' experience to documentation with pen and paper. Proxemo is reliable, as well as more efficient, thorough and effective than handwritten notes and provides a better UX to observers. Proxemo compares well with existing methods where benchmarks are available. With Proxemo we contribute a validated structured observation method that has shown to meet requirements formative UX evaluations in the extreme contexts of users with cognitive impairments or high task demands. Proxemo is agnostic regarding researchers' theoretical approaches and unites reductionist and holistic perspectives within one method. Future work should explore the applicability of Proxemo for further domains and extend the list of audited quality criteria to include, for instance, downstream utility. With respect to basic research we strive to better understand the sources leading observers to empathic judgments and propose reminisce and older adults as model environment for investigating mixed emotions. N2 - Für formative Evaluationen der User Experience (UX) wurden im Laufe der Jahre zahlreiche Methoden entwickelt. Die meisten Methoden erfordern jedoch, dass die Benutzer als Nebenaufgabe mit der Studie interagieren. Diese aktive Beteiligung an der Evaluation kann das untersuchte Erlebnis verfälschen und schließt Benutzer komplett aus, die keine kognitiven Ressourcen zur Verfügung haben. Dies ist der Fall, wenn 1) die kognitiven Fähigkeiten der Benutzer beeinträchtigt sind (z. B. Menschen mit Demenz) oder 2) Benutzer mit sehr anspruchsvollen Aufgaben konfrontiert sind (z. B. Fluglotsen). In dieser Arbeit konzentrieren wir uns auf Emotionen als eine Schlüsselkomponente von UX und schlagen die neue strukturierte Beobachtungsmethode Proxemo für formative UX-Evaluationen vor. Proxemo ermöglicht es qualifizierten Beobachtern, die Emotionen der Nutzer in Echtzeit zu dokumentieren und sie direkt mit Auslösern zu verknüpfen. Technisch wird dies erreicht, indem die Zeitstempel der von den Beobachtern dokumentierten Emotionen mit einer Videoaufzeichnung der Interaktion synchronisiert werden. Um die Dokumentation von beobachteten Emotionen in sehr unterschiedlichen Kontexten zu erleichtern, konzipieren und implementieren wir zwei verschiedene Versionen einer Dokumentationshilfe namens Proxemo App. Für formative UX-Evaluationen von technologiegestützten Erinnerungssitzungen mit Menschen mit Demenz erstellen wir eine Smartwatch-App zur unauffälligen Dokumentation von Emotionen aus den Kategorien Ärger, allgemeine Wachsamkeit, Freude, Wehmut und Stolz. Für formative UX-Evaluationen prototypischer Nutzerschnittstellen mit Fluglotsen erstellen wir eine Smartphone-App zur effizienten Dokumentation von Emotionen aus den Kategorien Ärger, Langeweile, Überraschung, Stress und Stolz. Deskriptive Fallstudien in beiden Anwendungsfeldern zeigen die Machbarkeit und den Nutzen der Methode Proxemo und die Angemessenheit des jeweiligen Designs der Proxemo App. Der dritte Teil dieser Arbeit besteht aus einer Reihe von Meta-Evaluationsstudien zu den Gütekriterien von Proxemo. Wir evaluieren Proxemo hinsichtlich der Reliabilität, Validität, Gründlichkeit und Effektivität, und vergleichen die Effizienz von Proxemo und die UX der Beobachter mit der Dokumentation mit Stift und Papier. Proxemo ist reliabel, sowie effizienter, gründlicher und effektiver als handschriftliche Notizen und bietet den Beobachtern eine bessere UX. Proxemo schneidet gut ab im Vergleich zu bestehenden Methoden, für die Benchmarks verfügbar sind. Mit Proxemo stellen wir eine validierte, strukturierte Beobachtungsmethode vor, die nachweislich den Anforderungen formativer UX Evaluationen in den extremen Kontexten von Benutzern mit kognitiven Beeinträchtigungen oder hohen Aufgabenanforderungen gerecht wird. Proxemo ist agnostisch bezüglich der theoretischen Ansätze von Forschenden und vereint reduktionistische und ganzheitliche Perspektiven in einer Methode. Zukünftige Arbeiten sollten die Anwendbarkeit von Proxemo für weitere Domänen erkunden und die Liste der geprüften Gütekriterien erweitern, zum Beispiel um das Kriterium Downstream Utility. In Bezug auf die Grundlagenforschung werden wir versuchen, die Quellen besser zu verstehen, auf denen die empathischen Urteile der Beobachter fußen und schlagen Erinnerungen und ältere Erwachsene als Modellumgebung für die künftige Erforschung gemischter Emotionen vor. KW - Gefühl KW - Wissenschaftliche Beobachtung KW - Methode KW - Benutzererlebnis KW - Benutzerforschung KW - Emotionserkennung KW - Emotion inference KW - Emotionsinterpretation Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-305730 ER - TY - JOUR A1 - Koopmann, Tobias A1 - Stubbemann, Maximilian A1 - Kapa, Matthias A1 - Paris, Michael A1 - Buenstorf, Guido A1 - Hanika, Tom A1 - Hotho, Andreas A1 - Jäschke, Robert A1 - Stumme, Gerd T1 - Proximity dimensions and the emergence of collaboration: a HypTrails study on German AI research JF - Scientometrics N2 - Creation and exchange of knowledge depends on collaboration. Recent work has suggested that the emergence of collaboration frequently relies on geographic proximity. However, being co-located tends to be associated with other dimensions of proximity, such as social ties or a shared organizational environment. To account for such factors, multiple dimensions of proximity have been proposed, including cognitive, institutional, organizational, social and geographical proximity. Since they strongly interrelate, disentangling these dimensions and their respective impact on collaboration is challenging. To address this issue, we propose various methods for measuring different dimensions of proximity. We then present an approach to compare and rank them with respect to the extent to which they indicate co-publications and co-inventions. We adapt the HypTrails approach, which was originally developed to explain human navigation, to co-author and co-inventor graphs. We evaluate this approach on a subset of the German research community, specifically academic authors and inventors active in research on artificial intelligence (AI). We find that social proximity and cognitive proximity are more important for the emergence of collaboration than geographic proximity. KW - collaboration KW - dimensions of proximity KW - co-authorships KW - co-inventorships KW - embedding techniques Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-269831 SN - 1588-2861 VL - 126 IS - 12 ER - TY - THES A1 - Schlosser, Daniel T1 - Quality of Experience Management in Virtual Future Networks T1 - Netzwerkmanagement unter Berücksichtigung der vom Benutzer erfahrenen Dienstgüte in virtuellen zukünftigen Netzen N2 - Aktuell beobachten wir eine drastische Vervielfältigung der Dienste und Anwendungen, die das Internet für den Datentransport nutzen. Dabei unterscheiden sich die Anforderungen dieser Dienste an das Netzwerk deutlich. Das Netzwerkmanagement wird durch diese Diversität der nutzenden Dienste aber deutlich erschwert, da es einem Datentransportdienstleister kaum möglich ist, die unterschiedlichen Verbindungen zu unterscheiden, ohne den Inhalt der transportierten Daten zu analysieren. Netzwerkvirtualisierung ist eine vielversprechende Lösung für dieses Problem, da sie es ermöglicht für verschiedene Dienste unterschiedliche virtuelle Netze auf dem gleichen physikalischen Substrat zu betreiben. Diese Diensttrennung ermöglicht es, jedes einzelne Netz anwendungsspezifisch zu steuern. Ziel einer solchen Netzsteuerung ist es, sowohl die vom Nutzer erfahrene Dienstgüte als auch die Kosteneffizienz des Datentransports zu optimieren. Darüber hinaus wird es mit Netzwerkvirtualisierung möglich das physikalische Netz so weit zu abstrahieren, dass die aktuell fest verzahnten Rollen von Netzwerkbesitzer und Netzwerkbetreiber entkoppelt werden können. Darüber hinaus stellt Netzwerkvirtualisierung sicher, dass unterschiedliche Datennetze, die gleichzeitig auf dem gleichen physikalischen Netz betrieben werden, sich gegenseitig weder beeinflussen noch stören können. Diese Arbeit  beschäftigt sich mit ausgewählten Aspekten dieses Themenkomplexes und fokussiert sich darauf, ein virtuelles Netzwerk mit bestmöglicher Dienstqualität für den Nutzer zu betreiben und zu steuern. Dafür wird ein Top-down-Ansatz gewählt, der von den Anwendungsfällen, einer möglichen Netzwerkvirtualisierungs-Architektur und aktuellen Möglichkeiten der Hardwarevirtualisierung ausgeht. Im Weiteren fokussiert sich die Arbeit dann in Richtung Bestimmung und Optimierung der vom Nutzer erfahrenen Dienstqualität (QoE) auf Applikationsschicht und diskutiert Möglichkeiten zur Messung und Überwachung von wesentlichen Netzparametern in virtualisierten Netzen. N2 - Currently, we observe a strong growth of services and applications, which use the Internet for data transport. However, the network requirements of these applications differ significantly. This makes network management difficult, since it complicated to separate network flows into application classes without inspecting application layer data. Network virtualization is a promising solution to this problem. It enables running different virtual network on the same physical substrate. Separating networks based on the service supported within allows controlling each network according to the specific needs of the application. The aim of such a network control is to optimize the user perceived quality as well as the cost efficiency of the data transport. Furthermore, network virtualization abstracts the network functionality from the underlying implementation and facilitates the split of the currently tightly integrated roles of Internet Service Provider and network owner. Additionally, network virtualization guarantees that different virtual networks run on the same physical substrate do not interfere with each other. This thesis discusses different aspects of the network virtualization topic. It is focused on how to manage and control a virtual network to guarantee the best Quality of Experience for the user. Therefore, a top-down approach is chosen. Starting with use cases of virtual networks, a possible architecture is derived and current implementation options based on hardware virtualization are explored. In the following, this thesis focuses on assessing the Quality of Experience perceived by the user and how it can be optimized on application layer. Furthermore, options for measuring and monitoring significant network parameters of virtual networks are considered. T3 - Würzburger Beiträge zur Leistungsbewertung Verteilter Systeme - 01/12 KW - Netzwerkmanagement KW - Dienstgüte KW - Netzwerkvirtualisierung KW - QoS KW - QoE KW - Network Virtualization KW - Quality of Experience KW - Network Management KW - Quality of Service Y1 - 2011 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-69986 ER - TY - JOUR A1 - Singh, Amit K. A1 - Kingston, Joseph J. A1 - Gupta, Shishir K. A1 - Batra, Harsh V. T1 - Recombinant Bivalent Fusion Protein rVE Induces CD4+ and CD8+ T-Cell Mediated Memory Immune Response for Protection Against Yersinia enterocolitica Infection JF - Frontiers in Microbiology N2 - Studies investigating the correlates of immune protection against Yersinia infection have established that both humoral and cell mediated immune responses are required for the comprehensive protection. In our previous study, we established that the bivalent fusion protein (rVE) comprising immunologically active regions of Y pestis LcrV (100-270 aa) and YopE (50-213 aa) proteins conferred complete passive and active protection against lethal Y enterocolitica 8081 challenge. In the present study, cohort of BALB/c mice immunized with rVE or its component proteins rV, rE were assessed for cell mediated immune responses and memory immune protection against Y enterocolitica 8081 rVE immunization resulted in extensive proliferation of both CD4 and CD8 T cell subsets; significantly high antibody titer with balanced IgG1: IgG2a/IgG2b isotypes (1:1 ratio) and up regulation of both Th1 (INF-\(\alpha\), IFN-\(\gamma\), IL 2, and IL 12) and Th2 (IL 4) cytokines. On the other hand, rV immunization resulted in Th2 biased IgG response (11:1 ratio) and proliferation of CD4+ T-cell; rE group of mice exhibited considerably lower serum antibody titer with predominant Th1 response (1:3 ratio) and CD8+ T-cell proliferation. Comprehensive protection with superior survival (100%) was observed among rVE immunized mice when compared to the significantly lower survival rates among rE (37.5%) and rV (25%) groups when IP challenged with Y enterocolitica 8081 after 120 days of immunization. Findings in this and our earlier studies define the bivalent fusion protein rVE as a potent candidate vaccine molecule with the capability to concurrently stimulate humoral and cell mediated immune responses and a proof of concept for developing efficient subunit vaccines against Gram negative facultative intracellular bacterial pathogens. KW - I-tasser KW - Yersinia enterocolitica KW - memory immune responses KW - cytokine profiling KW - CD8+T cells KW - CD4+T cells KW - recombinant protein rVE KW - resistance KW - pneumonic plague KW - pestis infection KW - nonhuman-primates KW - III secretion KW - V-antigen KW - mice KW - vaccine Y1 - 2015 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-136114 VL - 6 IS - 1407 ER -