TY - JOUR A1 - Wienrich, Carolin A1 - Latoschik, Marc Erich T1 - eXtended Artificial Intelligence: New Prospects of Human-AI Interaction Research JF - Frontiers in Virtual Reality N2 - Artificial Intelligence (AI) covers a broad spectrum of computational problems and use cases. Many of those implicate profound and sometimes intricate questions of how humans interact or should interact with AIs. Moreover, many users or future users do have abstract ideas of what AI is, significantly depending on the specific embodiment of AI applications. Human-centered-design approaches would suggest evaluating the impact of different embodiments on human perception of and interaction with AI. An approach that is difficult to realize due to the sheer complexity of application fields and embodiments in reality. However, here XR opens new possibilities to research human-AI interactions. The article’s contribution is twofold: First, it provides a theoretical treatment and model of human-AI interaction based on an XR-AI continuum as a framework for and a perspective of different approaches of XR-AI combinations. It motivates XR-AI combinations as a method to learn about the effects of prospective human-AI interfaces and shows why the combination of XR and AI fruitfully contributes to a valid and systematic investigation of human-AI interactions and interfaces. Second, the article provides two exemplary experiments investigating the aforementioned approach for two distinct AI-systems. The first experiment reveals an interesting gender effect in human-robot interaction, while the second experiment reveals an Eliza effect of a recommender system. Here the article introduces two paradigmatic implementations of the proposed XR testbed for human-AI interactions and interfaces and shows how a valid and systematic investigation can be conducted. In sum, the article opens new perspectives on how XR benefits human-centered AI design and development. KW - human-artificial intelligence interface KW - human-artificial intelligence interaction KW - XR-artificial intelligence continuum KW - XR-artificial intelligence combination KW - research methods KW - human-centered, human-robot KW - recommender system Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-260296 VL - 2 ER - TY - THES A1 - Niebler, Thomas T1 - Extracting and Learning Semantics from Social Web Data T1 - Extraktion und Lernen von Semantik aus Social Web-Daten N2 - Making machines understand natural language is a dream of mankind that existed since a very long time. Early attempts at programming machines to converse with humans in a supposedly intelligent way with humans relied on phrase lists and simple keyword matching. However, such approaches cannot provide semantically adequate answers, as they do not consider the specific meaning of the conversation. Thus, if we want to enable machines to actually understand language, we need to be able to access semantically relevant background knowledge. For this, it is possible to query so-called ontologies, which are large networks containing knowledge about real-world entities and their semantic relations. However, creating such ontologies is a tedious task, as often extensive expert knowledge is required. Thus, we need to find ways to automatically construct and update ontologies that fit human intuition of semantics and semantic relations. More specifically, we need to determine semantic entities and find relations between them. While this is usually done on large corpora of unstructured text, previous work has shown that we can at least facilitate the first issue of extracting entities by considering special data such as tagging data or human navigational paths. Here, we do not need to detect the actual semantic entities, as they are already provided because of the way those data are collected. Thus we can mainly focus on the problem of assessing the degree of semantic relatedness between tags or web pages. However, there exist several issues which need to be overcome, if we want to approximate human intuition of semantic relatedness. For this, it is necessary to represent words and concepts in a way that allows easy and highly precise semantic characterization. This also largely depends on the quality of data from which these representations are constructed. In this thesis, we extract semantic information from both tagging data created by users of social tagging systems and human navigation data in different semantic-driven social web systems. Our main goal is to construct high quality and robust vector representations of words which can the be used to measure the relatedness of semantic concepts. First, we show that navigation in the social media systems Wikipedia and BibSonomy is driven by a semantic component. After this, we discuss and extend methods to model the semantic information in tagging data as low-dimensional vectors. Furthermore, we show that tagging pragmatics influences different facets of tagging semantics. We then investigate the usefulness of human navigational paths in several different settings on Wikipedia and BibSonomy for measuring semantic relatedness. Finally, we propose a metric-learning based algorithm in adapt pre-trained word embeddings to datasets containing human judgment of semantic relatedness. This work contributes to the field of studying semantic relatedness between words by proposing methods to extract semantic relatedness from web navigation, learn highquality and low-dimensional word representations from tagging data, and to learn semantic relatedness from any kind of vector representation by exploiting human feedback. Applications first and foremest lie in ontology learning for the Semantic Web, but also semantic search or query expansion. N2 - Einer der großen Träume der Menschheit ist es, Maschinen dazu zu bringen, natürliche Sprache zu verstehen. Frühe Versuche, Computer dahingehend zu programmieren, dass sie mit Menschen vermeintlich intelligente Konversationen führen können, basierten hauptsächlich auf Phrasensammlungen und einfachen Stichwortabgleichen. Solche Ansätze sind allerdings nicht in der Lage, inhaltlich adäquate Antworten zu liefern, da der tatsächliche Inhalt der Konversation nicht erfasst werden kann. Folgerichtig ist es notwendig, dass Maschinen auf semantisch relevantes Hintergrundwissen zugreifen können, um diesen Inhalt zu verstehen. Solches Wissen ist beispielsweise in Ontologien vorhanden. Ontologien sind große Datenbanken von vernetztem Wissen über Objekte und Gegenstände der echten Welt sowie über deren semantische Beziehungen. Das Erstellen solcher Ontologien ist eine sehr kostspielige und aufwändige Aufgabe, da oft tiefgreifendes Expertenwissen benötigt wird. Wir müssen also Wege finden, um Ontologien automatisch zu erstellen und aktuell zu halten, und zwar in einer Art und Weise, dass dies auch menschlichem Empfinden von Semantik und semantischer Ähnlichkeit entspricht. Genauer gesagt ist es notwendig, semantische Entitäten und deren Beziehungen zu bestimmen. Während solches Wissen üblicherweise aus Textkorpora extrahiert wird, ist es möglich, zumindest das erste Problem - semantische Entitäten zu bestimmen - durch Benutzung spezieller Datensätze zu umgehen, wie zum Beispiel Tagging- oder Navigationsdaten. In diesen Arten von Datensätzen ist es nicht notwendig, Entitäten zu extrahieren, da sie bereits aufgrund inhärenter Eigenschaften bei der Datenakquise vorhanden sind. Wir können uns also hauptsächlich auf die Bestimmung von semantischen Relationen und deren Intensität fokussieren. Trotzdem müssen hier noch einige Hindernisse überwunden werden. Beispielsweise ist es notwendig, Repräsentationen für semantische Entitäten zu finden, so dass es möglich ist, sie einfach und semantisch hochpräzise zu charakterisieren. Dies hängt allerdings auch erheblich von der Qualität der Daten ab, aus denen diese Repräsentationen konstruiert werden. In der vorliegenden Arbeit extrahieren wir semantische Informationen sowohl aus Taggingdaten, von Benutzern sozialer Taggingsysteme erzeugt, als auch aus Navigationsdaten von Benutzern semantikgetriebener Social Media-Systeme. Das Hauptziel dieser Arbeit ist es, hochqualitative und robuste Vektordarstellungen von Worten zu konstruieren, die dann dazu benutzt werden können, die semantische Ähnlichkeit von Konzepten zu bestimmen. Als erstes zeigen wir, dass Navigation in Social Media Systemen unter anderem durch eine semantische Komponente getrieben wird. Danach diskutieren und erweitern wir Methoden, um die semantische Information in Taggingdaten als niedrigdimensionale sogenannte “Embeddings” darzustellen. Darüberhinaus demonstrieren wir, dass die Taggingpragmatik verschiedene Facetten der Taggingsemantik beeinflusst. Anschließend untersuchen wir, inwieweit wir menschliche Navigationspfade zur Bestimmung semantischer Ähnlichkeit benutzen können. Hierzu betrachten wir mehrere Datensätze, die Navigationsdaten in verschiedenen Rahmenbedingungen beinhalten. Als letztes stellen wir einen neuartigen Algorithmus vor, um bereits trainierte Word Embeddings im Nachhinein an menschliche Intuition von Semantik anzupassen. Diese Arbeit steuert wertvolle Beiträge zum Gebiet der Bestimmung von semantischer Ähnlichkeit bei: Es werden Methoden vorgestellt werden, um hochqualitative semantische Information aus Web-Navigation und Taggingdaten zu extrahieren, diese mittels niedrigdimensionaler Vektordarstellungen zu modellieren und selbige schließlich besser an menschliches Empfinden von semantischer Ähnlichkeit anzupassen, indem aus genau diesem Empfinden gelernt wird. Anwendungen liegen in erster Linie darin, Ontologien für das Semantic Web zu lernen, allerdings auch in allen Bereichen, die Vektordarstellungen von semantischen Entitäten benutzen. KW - Semantik KW - Maschinelles Lernen KW - Soziale Software KW - Semantics KW - User Behavior KW - Social Web KW - Machine Learning Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-178666 ER - TY - THES A1 - Budig, Benedikt T1 - Extracting Spatial Information from Historical Maps: Algorithms and Interaction T1 - Extraktion räumlicher Informationen aus historischen Landkarten: Algorithmen und Interaktion N2 - Historical maps are fascinating documents and a valuable source of information for scientists of various disciplines. Many of these maps are available as scanned bitmap images, but in order to make them searchable in useful ways, a structured representation of the contained information is desirable. This book deals with the extraction of spatial information from historical maps. This cannot be expected to be solved fully automatically (since it involves difficult semantics), but is also too tedious to be done manually at scale. The methodology used in this book combines the strengths of both computers and humans: it describes efficient algorithms to largely automate information extraction tasks and pairs these algorithms with smart user interactions to handle what is not understood by the algorithm. The effectiveness of this approach is shown for various kinds of spatial documents from the 16th to the early 20th century. N2 - Historische Landkarten sind faszinierende Dokumente und eine wertvolle Informationsquelle für Wissenschaftler verschiedener Fächer. Viele dieser Karten liegen als gescannte Bitmap-Bilder vor, aber um sie auf nützliche Art durchsuchbar zu machen ist eine strukturierte Repräsentation der enthaltenen Informationen wünschenswert. Dieses Buch beschäftigt sich mit der Extraktion räumlicher Informationen aus historischen Landkarten. Man kann nicht erwarten, dass dies vollautomatisch geschieht (da komplizierte Semantik involviert ist), aber es ist auch zu aufwändig, um im großen Stil manuell durchgeführt zu werden. Die Methodik, die in diesem Buch verwendet wird, kombiniert die Stärken von Computern und Menschen: Es werden effiziente Algorithmen beschrieben, die Extraktionsaufgaben weitgehend automatisieren, und dazu passende Nutzerinteraktionen entworfen, mit denen Fälle gelöst werden, die die Algorithmen nicht vestehen. Die Effekitivität dieses Ansatzes wird anhand verschiedener räumlicher Dokumente aus dem 16. bis frühen 20. Jahrhundert gezeigt. KW - Karte KW - Effizienter Algorithmus KW - Interaktion KW - Information Extraction KW - Smart User Interaction KW - Historical Maps KW - Itineraries KW - Deep Georeferencing KW - Benutzerinteraktion KW - Historische Landkarten KW - Itinerare KW - Georeferenzierung KW - Historische Karte KW - Raumdaten Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-160955 SN - 978-3-95826-092-4 SN - 978-3-95826-093-1 N1 - Parallel erschienen als Druckausgabe in Würzburg University Press, ISBN 978-3-95826-092-4, 32,90 Euro. PB - Würzburg University Press CY - Würzburg ET - 1. Auflage ER - TY - JOUR A1 - Krenzer, Adrian A1 - Makowski, Kevin A1 - Hekalo, Amar A1 - Fitting, Daniel A1 - Troya, Joel A1 - Zoller, Wolfram G. A1 - Hann, Alexander A1 - Puppe, Frank T1 - Fast machine learning annotation in the medical domain: a semi-automated video annotation tool for gastroenterologists JF - BioMedical Engineering OnLine N2 - Background Machine learning, especially deep learning, is becoming more and more relevant in research and development in the medical domain. For all the supervised deep learning applications, data is the most critical factor in securing successful implementation and sustaining the progress of the machine learning model. Especially gastroenterological data, which often involves endoscopic videos, are cumbersome to annotate. Domain experts are needed to interpret and annotate the videos. To support those domain experts, we generated a framework. With this framework, instead of annotating every frame in the video sequence, experts are just performing key annotations at the beginning and the end of sequences with pathologies, e.g., visible polyps. Subsequently, non-expert annotators supported by machine learning add the missing annotations for the frames in-between. Methods In our framework, an expert reviews the video and annotates a few video frames to verify the object’s annotations for the non-expert. In a second step, a non-expert has visual confirmation of the given object and can annotate all following and preceding frames with AI assistance. After the expert has finished, relevant frames will be selected and passed on to an AI model. This information allows the AI model to detect and mark the desired object on all following and preceding frames with an annotation. Therefore, the non-expert can adjust and modify the AI predictions and export the results, which can then be used to train the AI model. Results Using this framework, we were able to reduce workload of domain experts on average by a factor of 20 on our data. This is primarily due to the structure of the framework, which is designed to minimize the workload of the domain expert. Pairing this framework with a state-of-the-art semi-automated AI model enhances the annotation speed further. Through a prospective study with 10 participants, we show that semi-automated annotation using our tool doubles the annotation speed of non-expert annotators compared to a well-known state-of-the-art annotation tool. Conclusion In summary, we introduce a framework for fast expert annotation for gastroenterologists, which reduces the workload of the domain expert considerably while maintaining a very high annotation quality. The framework incorporates a semi-automated annotation system utilizing trained object detection models. The software and framework are open-source. KW - object detection KW - machine learning KW - deep learning KW - annotation KW - endoscopy KW - gastroenterology KW - automation Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-300231 VL - 21 IS - 1 ER - TY - RPRT A1 - Dworzak, Manuel A1 - Großmann, Marcel A1 - Le, Duy Thanh T1 - Federated Learning for Service Placement in Fog and Edge Computing T2 - KuVS Fachgespräch - Würzburg Workshop on Modeling, Analysis and Simulation of Next-Generation Communication Networks 2023 (WueWoWAS’23) N2 - Service orchestration requires enormous attention and is a struggle nowadays. Of course, virtualization provides a base level of abstraction for services to be deployable on a lot of infrastructures. With container virtualization, the trend to migrate applications to a micro-services level in order to be executable in Fog and Edge Computing environments increases manageability and maintenance efforts rapidly. Similarly, network virtualization adds effort to calibrate IP flows for Software-Defined Networks and eventually route it by means of Network Function Virtualization. Nevertheless, there are concepts like MAPE-K to support micro-service distribution in next-generation cloud and network environments. We want to explore, how a service distribution can be improved by adopting machine learning concepts for infrastructure or service changes. Therefore, we show how federated machine learning is integrated into a cloud-to-fog-continuum without burdening single nodes. KW - fog computing KW - SDN KW - orchestration KW - federated learning Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-322193 ER - TY - JOUR A1 - Kaltdorf, Kristin Verena A1 - Schulze, Katja A1 - Helmprobst, Frederik A1 - Kollmannsberger, Philip A1 - Dandekar, Thomas A1 - Stigloher, Christian T1 - Fiji macro 3D ART VeSElecT: 3D automated reconstruction tool for vesicle structures of electron tomograms JF - PLoS Computational Biology N2 - Automatic image reconstruction is critical to cope with steadily increasing data from advanced microscopy. We describe here the Fiji macro 3D ART VeSElecT which we developed to study synaptic vesicles in electron tomograms. We apply this tool to quantify vesicle properties (i) in embryonic Danio rerio 4 and 8 days past fertilization (dpf) and (ii) to compare Caenorhabditis elegans N2 neuromuscular junctions (NMJ) wild-type and its septin mutant (unc-59(e261)). We demonstrate development-specific and mutant-specific changes in synaptic vesicle pools in both models. We confirm the functionality of our macro by applying our 3D ART VeSElecT on zebrafish NMJ showing smaller vesicles in 8 dpf embryos then 4 dpf, which was validated by manual reconstruction of the vesicle pool. Furthermore, we analyze the impact of C. elegans septin mutant unc-59(e261) on vesicle pool formation and vesicle size. Automated vesicle registration and characterization was implemented in Fiji as two macros (registration and measurement). This flexible arrangement allows in particular reducing false positives by an optional manual revision step. Preprocessing and contrast enhancement work on image-stacks of 1nm/pixel in x and y direction. Semi-automated cell selection was integrated. 3D ART VeSElecT removes interfering components, detects vesicles by 3D segmentation and calculates vesicle volume and diameter (spherical approximation, inner/outer diameter). Results are collected in color using the RoiManager plugin including the possibility of manual removal of non-matching confounder vesicles. Detailed evaluation considered performance (detected vesicles) and specificity (true vesicles) as well as precision and recall. We furthermore show gain in segmentation and morphological filtering compared to learning based methods and a large time gain compared to manual segmentation. 3D ART VeSElecT shows small error rates and its speed gain can be up to 68 times faster in comparison to manual annotation. Both automatic and semi-automatic modes are explained including a tutorial. KW - Biology KW - Vesicles KW - Caenorhabditis elegans KW - Zebrafish KW - Septins KW - Synaptic vesicles KW - Neuromuscular junctions KW - Computer software KW - Synapses Y1 - 2017 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-172112 VL - 13 IS - 1 ER - TY - JOUR A1 - Toepfer, Martin A1 - Corovic, Hamo A1 - Fette, Georg A1 - Klügl, Peter A1 - Störk, Stefan A1 - Puppe, Frank T1 - Fine-grained information extraction from German transthoracic echocardiography reports JF - BMC Medical Informatics and Decision Making N2 - Background Information extraction techniques that get structured representations out of unstructured data make a large amount of clinically relevant information about patients accessible for semantic applications. These methods typically rely on standardized terminologies that guide this process. Many languages and clinical domains, however, lack appropriate resources and tools, as well as evaluations of their applications, especially if detailed conceptualizations of the domain are required. For instance, German transthoracic echocardiography reports have not been targeted sufficiently before, despite of their importance for clinical trials. This work therefore aimed at development and evaluation of an information extraction component with a fine-grained terminology that enables to recognize almost all relevant information stated in German transthoracic echocardiography reports at the University Hospital of Würzburg. Methods A domain expert validated and iteratively refined an automatically inferred base terminology. The terminology was used by an ontology-driven information extraction system that outputs attribute value pairs. The final component has been mapped to the central elements of a standardized terminology, and it has been evaluated according to documents with different layouts. Results The final system achieved state-of-the-art precision (micro average.996) and recall (micro average.961) on 100 test documents that represent more than 90 % of all reports. In particular, principal aspects as defined in a standardized external terminology were recognized with f 1=.989 (micro average) and f 1=.963 (macro average). As a result of keyword matching and restraint concept extraction, the system obtained high precision also on unstructured or exceptionally short documents, and documents with uncommon layout. Conclusions The developed terminology and the proposed information extraction system allow to extract fine-grained information from German semi-structured transthoracic echocardiography reports with very high precision and high recall on the majority of documents at the University Hospital of Würzburg. Extracted results populate a clinical data warehouse which supports clinical research. Y1 - 2015 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-125509 VL - 15 IS - 91 ER - TY - THES A1 - Glaßer, Christian T1 - Forbidden-Patterns and Word Extensions for Concatenation Hierarchies T1 - Verbotsmuster und Worterweiterungen für Konkatenationshierarchien N2 - Starfree regular languages can be build up from alphabet letters by using only Boolean operations and concatenation. The complexity of these languages can be measured with the so-called dot-depth. This measure leads to concatenation hierarchies like the dot-depth hierarchy (DDH) and the closely related Straubing-Thérien hierarchy (STH). The question whether the single levels of these hierarchies are decidable is still open and is known as the dot-depth problem. In this thesis we prove/reprove the decidability of some lower levels of both hierarchies. More precisely, we characterize these levels in terms of patterns in finite automata (subgraphs in the transition graph) that are not allowed. Therefore, such characterizations are called forbidden-pattern characterizations. The main results of the thesis are as follows: forbidden-pattern characterization for level 3/2 of the DDH (this implies the decidability of this level) decidability of the Boolean hierarchy over level 1/2 of the DDH definition of decidable hierarchies having close relations to the DDH and STH Moreover, we prove/reprove the decidability of the levels 1/2 and 3/2 of both hierarchies in terms of forbidden-pattern characterizations. We show the decidability of the Boolean hierarchies over level 1/2 of the DDH and over level 1/2 of the STH. A technique which uses word extensions plays the central role in the proofs of these results. With this technique it is possible to treat the levels 1/2 and 3/2 of both hierarchies in a uniform way. Furthermore, it can be used to prove the decidability of the mentioned Boolean hierarchies. Among other things we provide a combinatorial tool that allows to partition words of arbitrary length into factors of bounded length such that every second factor u leads to a loop with label u in a given finite automaton. N2 - Sternfreie reguläre Sprachen können aus Buchstaben unter Verwendung Boolescher Operationen und Konkatenation aufgebaut werden. Die Komplexität solcher Sprachen lässt sich durch die sogenannte "Dot-Depth" messen. Dieses Maß führt zu Konkatenationshierarchien wie der Dot-Depth-Hierachie (DDH) und der Straubing-Thérien-Hierarchie (STH). Die Frage nach der Entscheidbarkeit der einzelnen Stufen dieser Hierarchien ist als (immer noch offenes) Dot-Depth-Problem bekannt. In dieser Arbeit beweisen wir die Entscheidbarkeit einiger unterer Stufen beider Hierarchien. Genauer gesagt charakterisieren wir diese Stufen durch das Verbot von bestimmten Mustern in endlichen Automaten. Solche Charakterisierungen werden Verbotsmustercharakterisierungen genannt. Die Hauptresultate der Arbeit lassen sich wie folgt zusammenfassen: Verbotsmustercharakterisierung der Stufe 3/2 der DDH (dies hat die Entscheidbarkeit dieser Stufe zur Folge) Entscheidbarkeit der Booleschen Hierarchie über der Stufe 1/2 der DDH Definition von entscheidbaren Hierarchien mit engen Verbindungen zur DDH und STH Darüber hinaus beweisen wir die Entscheidbarkeit der Stufen 1/2 und 3/2 beider Hierarchien (wieder mittels Verbotsmustercharakterisierungen) und die der Booleschen Hierarchien über den Stufen 1/2 der DDH bzw. STH. Dabei stützen sich die Beweise größtenteils auf eine Technik, die von Eigenschaften bestimmter Worterweiterungen Gebrauch macht. Diese Technik erlaubt eine einheitliche Vorgehensweise bei der Untersuchung der Stufen 1/2 und 3/2 beider Hierarchien. Außerdem wird sie in den Beweisen der Entscheidbarkeit der genannten Booleschen Hierarchien verwendet. Unter anderem wird ein kombinatorisches Hilfsmittel zur Verfügung gestellt, das es erlaubt, Wörter beliebiger Länge in Faktoren beschränkter Länge zu zerlegen, so dass jeder zweite Faktor u zu einer u-Schleife in einem gegebenen endlichen Automaten führt. KW - Automatentheorie KW - Formale Sprache KW - Entscheidbarkeit KW - Reguläre Sprache KW - Berechenbarkeit KW - Theoretische Informatik KW - reguläre Sprachen KW - endliche Automaten KW - Dot-Depth Problem KW - Entscheidbarkeit KW - Verbotsmuster KW - Worterweiterungen KW - Theoretical Computer Science KW - regular languages KW - finite automata KW - dot-depth problem KW - decidability KW - forbidden patterns KW - word extensions Y1 - 2001 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-1179153 ER - TY - THES A1 - Reith, Steffen T1 - Generalized Satisfiability Problems T1 - Verallgemeinerte Erfüllbarkeitsprobleme N2 - In the last 40 years, complexity theory has grown to a rich and powerful field in theoretical computer science. The main task of complexity theory is the classification of problems with respect to their consumption of resources (e.g., running time or required memory). To study the computational complexity (i.e., consumption of resources) of problems, similar problems are grouped into so called complexity classes. During the systematic study of numerous problems of practical relevance, no efficient algorithm for a great number of studied problems was found. Moreover, it was unclear whether such algorithms exist. A major breakthrough in this situation was the introduction of the complexity classes P and NP and the identification of hardest problems in NP. These hardest problems of NP are nowadays known as NP-complete problems. One prominent example of an NP-complete problem is the satisfiability problem of propositional formulas (SAT). Here we get a propositional formula as an input and it must be decided whether an assignment for the propositional variables exists, such that this assignment satisfies the given formula. The intensive study of NP led to numerous related classes, e.g., the classes of the polynomial-time hierarchy PH, P, #P, PP, NL, L and #L. During the study of these classes, problems related to propositional formulas were often identified to be complete problems for these classes. Hence some questions arise: Why is SAT so hard to solve? Are there modifications of SAT which are complete for other well-known complexity classes? In the context of these questions a result by E. Post is extremely useful. He identified and characterized all classes of Boolean functions being closed under superposition. It is possible to study problems which are connected to generalized propositional logic by using this result, which was done in this thesis. Hence, many different problems connected to propositional logic were studied and classified with respect to their computational complexity, clearing the borderline between easy and hard problems. N2 - In den letzten 40 Jahren hat sich die Komplexitätstheorie zu einem reichen und mächtigen Gebiet innerhalb der theoretischen Informatik entwickelt. Dabei ist die hauptsächliche Aufgabenstellung der Komplexitätstheorie die Klassifikation von Problemen bezüglich des Bedarfs von Rechenzeit oder Speicherplatz zu ihrer Lösung. Um die Komplexität von Problemen (d.h. den Bedarf von Resourcen) einzuordnen, werden Probleme mit ähnlichem Ressourcenbedarf in gleiche sogenannte Komplexitätsklassen einsortiert. Bei der systematischen Untersuchung einer Vielzahl von praktisch relevanten Problemen wurden jedoch keine effizienten Algorithmen für viele der untersuchten Probleme gefunden und es ist unklar, ob solche Algorithmen überhaupt existieren. Ein Durchbruch bei der Untersuchung dieser Problematik war die Einführung der Komplexitätsklassen P und NP und die Identifizierung von schwersten Problemen in NP. Diese schwierigsten Probleme von NP sind heute als sogenannte NP-vollständige Probleme bekannt. Ein prominentes Beispiel für ein NP-vollständiges Problem ist das Erfüllbarkeitsproblem für aussagenlogische Formeln (SAT). Hier ist eine aussagenlogische Formel als Eingabe gegeben und es muss bestimmt werden, ob eine Belegung der Wahrheitswertevariablen existiert, so dass diese Belegung die gegebene Formel erfüllt. Das intensive Studium der Klasse NP führte zu einer Vielzahl von anderen Komplexitätsklassen, wie z.B. die der Polynomialzeithierarchie PH, P, #P, PP, NL, L oder #L. Beim Studium dieser Klassen wurden sehr oft Probleme im Zusammenhang mit aussagenlogischen Formeln als schwierigste (vollständige) Probleme für diese Klassen identifiziert. Deshalb stellt sich folgende Frage: Welche Eigenschaften des Erfüllbarkeitsproblems SAT bewirken, dass es eines der schwersten Probleme der Klasse NP ist? Gibt es Einschränkungen oder Verallgemeinerungen des Erfüllbarkeitsproblems, die vollständig für andere bekannte Komplexitätsklassen sind? Im Zusammenhang mit solchen Fragestellungen ist ein Ergebnis von E. Post von extremem Nutzen. Er identifizierte und charakterisierte alle Klassen von Booleschen Funktionen, die unter Superposition abgeschlossen sind. Mit Hilfe dieses Resultats ist es möglich, Probleme im Zusammenhang mit verallgemeinerten Aussagenlogiken zu studieren, was in der vorliegenden Arbeit durchgeführt wurde. Dabei wurde eine Vielzahl von verschiedenen Problemen, die in Zusammenhang mit der Aussagenlogik stehen, studiert und bezüglich ihrer Komplexität klassifiziert. Dadurch wird die Grenzlinie zwischen einfach lösbaren Problemen und schweren Problemen sichtbar. KW - Erfüllbarkeitsproblem KW - Komplexitätstheorie KW - Boolesche Funktionen KW - Isomorphie KW - abgeschlossene Klassen KW - Zählprobleme KW - Computational complexity KW - Boolean functions KW - Boolean isomorphism KW - Boolean equivalence KW - Dichotomy KW - counting problems Y1 - 2001 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-74 ER - TY - JOUR A1 - Appel, Mirjam A1 - Scholz, Claus-Jürgen A1 - Müller, Tobias A1 - Dittrich, Marcus A1 - König, Christian A1 - Bockstaller, Marie A1 - Oguz, Tuba A1 - Khalili, Afshin A1 - Antwi-Adjei, Emmanuel A1 - Schauer, Tamas A1 - Margulies, Carla A1 - Tanimoto, Hiromu A1 - Yarali, Ayse T1 - Genome-Wide Association Analyses Point to Candidate Genes for Electric Shock Avoidance in Drosophila melanogaster JF - PLoS ONE N2 - Electric shock is a common stimulus for nociception-research and the most widely used reinforcement in aversive associative learning experiments. Yet, nothing is known about the mechanisms it recruits at the periphery. To help fill this gap, we undertook a genome-wide association analysis using 38 inbred Drosophila melanogaster strains, which avoided shock to varying extents. We identified 514 genes whose expression levels and/or sequences covaried with shock avoidance scores. We independently scrutinized 14 of these genes using mutants, validating the effect of 7 of them on shock avoidance. This emphasizes the value of our candidate gene list as a guide for follow-up research. In addition, by integrating our association results with external protein-protein interaction data we obtained a shock avoidance- associated network of 38 genes. Both this network and the original candidate list contained a substantial number of genes that affect mechanosensory bristles, which are hairlike organs distributed across the fly's body. These results may point to a potential role for mechanosensory bristles in shock sensation. Thus, we not only provide a first list of candidate genes for shock avoidance, but also point to an interesting new hypothesis on nociceptive mechanisms. KW - functional analysis KW - disruption project KW - natural variation KW - complex traits KW - networks KW - behavior KW - flies KW - temperature KW - genetics KW - painful Y1 - 2015 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-152006 VL - 10 IS - 5 ER - TY - JOUR A1 - Maiwald, Ferdinand A1 - Bruschke, Jonas A1 - Schneider, Danilo A1 - Wacker, Markus A1 - Niebling, Florian T1 - Giving historical photographs a new perspective: introducing camera orientation parameters as new metadata in a large-scale 4D application JF - Remote Sensing N2 - The ongoing digitization of historical photographs in archives allows investigating the quality, quantity, and distribution of these images. However, the exact interior and exterior camera orientations of these photographs are usually lost during the digitization process. The proposed method uses content-based image retrieval (CBIR) to filter exterior images of single buildings in combination with metadata information. The retrieved photographs are automatically processed in an adapted structure-from-motion (SfM) pipeline to determine the camera parameters. In an interactive georeferencing process, the calculated camera positions are transferred into a global coordinate system. As all image and camera data are efficiently stored in the proposed 4D database, they can be conveniently accessed afterward to georeference newly digitized images by using photogrammetric triangulation and spatial resection. The results show that the CBIR and the subsequent SfM are robust methods for various kinds of buildings and different quantity of data. The absolute accuracy of the camera positions after georeferencing lies in the range of a few meters likely introduced by the inaccurate LOD2 models used for transformation. The proposed photogrammetric method, the database structure, and the 4D visualization interface enable adding historical urban photographs and 3D models from other locations. KW - historical images KW - 4D-GIS KW - content-based image retrieval KW - Structure-from-Motion KW - camera orientation KW - feature matching Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-311103 SN - 2072-4292 VL - 15 IS - 7 ER - TY - THES A1 - Schmidt, Marco T1 - Ground Station Networks for Efficient Operation of Distributed Small Satellite Systems T1 - Effizienter Betrieb von Verteilten Kleinsatelliten-Systemen mit Bodenstationsnetzwerken N2 - The field of small satellite formations and constellations attracted growing attention, based on recent advances in small satellite engineering. The utilization of distributed space systems allows the realization of innovative applications and will enable improved temporal and spatial resolution in observation scenarios. On the other side, this new paradigm imposes a variety of research challenges. In this monograph new networking concepts for space missions are presented, using networks of ground stations. The developed approaches combine ground station resources in a coordinated way to achieve more robust and efficient communication links. Within this thesis, the following topics were elaborated to improve the performance in distributed space missions: Appropriate scheduling of contact windows in a distributed ground system is a necessary process to avoid low utilization of ground stations. The theoretical basis for the novel concept of redundant scheduling was elaborated in detail. Additionally to the presented algorithm was a scheduling system implemented, its performance was tested extensively with real world scheduling problems. In the scope of data management, a system was developed which autonomously synchronizes data frames in ground station networks and uses this information to detect and correct transmission errors. The system was validated with hardware in the loop experiments, demonstrating the benefits of the developed approach. N2 - Satellitenformationen und Konstellationen rücken immer mehr in den Fokus aktueller Forschung, ausgelöst durch die jüngsten Fortschritte in der Kleinsatelliten-Entwicklung. Der Einsatz von verteilten Weltraumsystemen ermöglicht die Realisierung von innovativen Anwendungen auf Basis von hoher zeitlicher und räumlicher Auflösung in Observationsszenarien. Allerdings bringt dieses neue Paradigma der Raumfahrttechnik auch Herausforderungen in verschiedenen Forschungsfeldern mit sich. In dieser Dissertation werden neue Netzwerk-Konzepte für Raumfahrtmissionen unter Einsatz von Bodenstationnetzwerken vorgestellt. Die präsentierten Verfahren koordinieren verfügbare Bodenstationsressourcen um einen robusten und effizienten Kommunikationslink zu ermöglichen. In dieser Arbeit werden dabei folgende Themenfelder behandelt um die Performance in verteilten Raumfahrtmissionen zu steigern: Das Verteilen von Kontaktfenster (sogenanntes Scheduling) in verteilten Bodenstationssystem ist ein notwendiger Prozess um eine niedrige Auslastung der Stationen zu vermeiden. Die theoretische Grundlage für das Konzept des redundanten Scheduling wurde erarbeitet. Zusätztlich wurde das Verfahren in Form eines Scheduling Systems implementiert und dessen Performance ausführlich an real-world Szenarien getestet. Im Rahmen des Themenfeldes Data Management wurde ein System entwickelt, welches autonom Datenframes in Bodenstationsnetzwerken synchronisieren kann. Die in den Datenframes enthaltene Information wird genutzt um Übertragungsfehler zu erkennen und zu korrigieren. Das System wurde mit Hardware-in-the-loop Experimenten validiert und die Vorteile des entwickelten Verfahrens wurden gezeigt. T3 - Forschungsberichte in der Robotik = Research Notes in Robotics - 6 KW - Kleinsatellit KW - Bodenstation KW - Verteiltes System KW - Scheduling KW - Ground Station Networks KW - Small Satellites KW - Distributed Space Systems Y1 - 2011 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-64999 SN - 978-3-923959-77-8 ER - TY - THES A1 - Duelli, Michael T1 - Heuristic Design and Provisioning of Resilient Multi-Layer Networks T1 - Heuristische Planung und Betrieb von ausfallsicheren Mehrschichtnetzen N2 - To jointly provide different services/technologies, like IP and Ethernet or IP and SDH/SONET, in a single network, equipment of multiple technologies needs to be deployed to the sites/Points of Presence (PoP) and interconnected with each other. Therein, a technology may provide transport functionality to other technologies and increase the number of available resources by using multiplexing techniques. By providing its own switching functionality, each technology creates connections in a logical layer which leads to the notion of multi-layer networks. The design of such networks comprises the deployment and interconnection of components to suit to given traffic demands. To prevent traffic loss due to failures of networking equipment, protection mechanisms need to be established. In multi-layer networks, protection usually can be applied in any of the considered layers. In turn, the hierarchical structure of multi-layer networks also bears shared risk groups (SRG). To achieve a cost-optimal resilient network, an appropriate combination of multiplexing techniques, technologies, and their interconnections needs to be found. Thus, network design is a combinatorial problem with a large parameter and solution space. After the design stage, the resources of a multi-layer network can be provided to traffic demands. Especially, dynamic capacity provisioning requires interaction of sites and layers, as well as accurate retrieval of constraint information. In recent years, generalized multiprotocol label switching (GMPLS) and path computation elements (PCE) have emerged as possible approaches for these challenges. Like the design, the provisioning of multi-layer networks comprises a variety of optimization parameters, like blocking probability, resilience, and energy efficiency. In this work, we introduce several efficient heuristics to approach the considered optimization problems. We perform capital expenditure (CAPEX)-aware design of multi-layer networks from scratch, based on IST NOBEL phase 2 project's cost and equipment data. We comprise traffic and resilience requirements in different and multiple layers as well as different network architectures. On top of the designed networks, we consider the dynamic provisioning of multi-layer traffic based on the GMPLS and PCE architecture. We evaluate different PCE deployments, information retrieval strategies, and re-optimization. Finally, we show how information about provisioning utilization can be used to provide a feedback for network design. N2 - Um in einem Netz verschiedene Dienste/Schichten, z.B. IP und Ethernet oder IP und SDH/SONET, parallel anbieten zu können, müssen Komponenten mehrerer Technologien an den Standorten verbaut und miteinander verbunden werden. Hierbei kann eine Technologie eine Transportschicht für andere Technologien fungieren und die Zahl der verfügbaren Ressourcen durch Multiplex Techniken erhöhen. Durch die Bereitstellung eigener Switching Funktionalität erzeugt jede Technologie Verbindungen in einer logischen Schicht. Dies führt zu der Bezeichnung Mehrschichtnetz (engl. multi-layer network). Die Planung solcher Netze hat das Verbauen und Verbinden von Komponenten zum Ziel, so dass gegebene Verkehrsströme realisiert werden können. Um Unterbrechungen der Verkehrsströme aufgrund von Fehlern in den Netzkomponenten zu verhinden, müssen Schutzmechanismen eingebaut werden. In Mehrschichtnetzen können solche Schutzmechanismen in jeder beliebigen Schicht betrachtet werden. Allerdings birgt die hierarchische Struktur von Mehrschichtnetzen das Risiko von shared risk groups (SRG). Um ein Kosten-optimales ausfallsicheres Netz zu erhalten, muss eine passende Kombination aus Multiplex Techniken, Technologien und deren Verbindungen gefunden werden. Die Netzplanung ist daher ein kombinatorisches Problem mit einem großen Parameter- und Lösungsraum. Nach der Planungsphase können die Ressourcen eines Mehrschichtnetzes für Verkehrsströme vorgehalten werden. Die Betrachtung von dynamischer Kapazitätsanforderungen erfordert die Interaktion von Knoten und Schichten sowie akkurate Gewinnung von Informationen zur Auslastung. In jüngster Zeit sind das Generalized Multiprotocol Label Switching (GMPLS) und das Path Computation Element (PCE) als mögliche Lösungsansätze für diese Herausforderungen entstanden. Wie in der Planung beinhaltet auch der Betrieb von Mehrschichtnetzen eine Vielzahl von Optimierungsparametern, wie die Blockierungswahrscheinlichkeit, Ausfallsicherheit und Energie-Effizienz. In dieser Arbeit, führen wir verschiedene effiziente Heuristiken ein, um die betrachteten Optimierungsprobleme anzugehen. Wir planen Mehrschichtnetze von Grund auf und minimieren hinsichtlich der Anschaffungskosten basierend auf den Kosten- und Komponenten-Daten des IST NOBEL Phase 2 Projekts. Wir berücksichtigen Anforderungen der Verkehrsströme und Ausfallsicherheit in verschiedenen Schichten und in mehreren Schichten gleichzeitig sowie verschiedene Netzarchitekturen. Aufsetzend auf dem geplanten Netz betrachten wir den Betrieb von Mehrschichtnetzen mit dynamischen Verkehr basiert auf der GMPLS und PCE Architektur. Wir bewerten verschiedene PCE Installationen, Strategien zur Informationsgewinnung und Re-Optimierung. Abschließend, zeigen wir wie Information über die Auslastung im Betrieb genutzt werden kann um Rückmeldung an die Netzplanung zu geben. T3 - Würzburger Beiträge zur Leistungsbewertung Verteilter Systeme - 02/12 KW - Mehrschichtsystem KW - Planung KW - Ressourcenmanagement KW - Ausfallsicheres System KW - Mehrschichtnetze KW - Pfadberechnungselement KW - Ausfallsicherheit KW - Multi-Layer KW - Design KW - Resilience KW - Resource Management KW - Path Computation Element Y1 - 2012 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-69433 ER - TY - RPRT A1 - Funda, Christoph A1 - Konheiser, Tobias A1 - German, Reinhard A1 - Hielscher, Kai-Steffen T1 - How to Model and Predict the Scalability of a Hardware-In-The-Loop Test Bench for Data Re-Injection? T2 - KuVS Fachgespräch - Würzburg Workshop on Modeling, Analysis and Simulation of Next-Generation Communication Networks 2023 (WueWoWAS’23) N2 - This paper describes a novel application of an empirical network calculus model based on measurements of a hardware-in-the-loop (HIL) test system. The aim is to predict the performance of a HIL test bench for open-loop re-injection in the context of scalability. HIL test benches are distributed computer systems including software, hardware, and networking devices. They are used to validate complex technical systems, but have not yet been system under study themselves. Our approach is to use measurements from the HIL system to create an empirical model for arrival and service curves. We predict the performance and design the previously unknown parameters of the HIL simulator with network calculus (NC), namely the buffer sizes and the minimum needed pre-buffer time for the playback buffer. We furthermore show, that it is possible to estimate the CPU load from arrival and service-curves based on the utilization theorem, and hence estimate the scalability of the HIL system in the context of the number of sensor streams. KW - hardware-in-the-loop simulation KW - computer performance evaluation KW - network calculus KW - scalability evaluation Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-322150 ER - TY - THES A1 - Aschenbrenner, Doris T1 - Human Robot Interaction Concepts for Human Supervisory Control and Telemaintenance Applications in an Industry 4.0 Environment T1 - Mensch-Roboter-Interaktionskonzepte für Fernsteuerungs- und Fernwartungsanwendungen in einer Industrie 4.0 Umgebung N2 - While teleoperation of technical highly sophisticated systems has already been a wide field of research, especially for space and robotics applications, the automation industry has not yet benefited from its results. Besides the established fields of application, also production lines with industrial robots and the surrounding plant components are in need of being remotely accessible. This is especially critical for maintenance or if an unexpected problem cannot be solved by the local specialists. Special machine manufacturers, especially robotics companies, sell their technology worldwide. Some factories, for example in emerging economies, lack qualified personnel for repair and maintenance tasks. When a severe failure occurs, an expert of the manufacturer needs to fly there, which leads to long down times of the machine or even the whole production line. With the development of data networks, a huge part of those travels can be omitted, if appropriate teleoperation equipment is provided. This thesis describes the development of a telemaintenance system, which was established in an active production line for research purposes. The customer production site of Braun in Marktheidenfeld, a factory which belongs to Procter & Gamble, consists of a six-axis cartesian industrial robot by KUKA Industries, a two-component injection molding system and an assembly unit. The plant produces plastic parts for electric toothbrushes. In the research projects "MainTelRob" and "Bayern.digital", during which this plant was utilised, the Zentrum für Telematik e.V. (ZfT) and its project partners develop novel technical approaches and procedures for modern telemaintenance. The term "telemaintenance" hereby refers to the integration of computer science and communication technologies into the maintenance strategy. It is particularly interesting for high-grade capital-intensive goods like industrial robots. Typical telemaintenance tasks are for example the analysis of a robot failure or difficult repair operations. The service department of KUKA Industries is responsible for the worldwide distributed customers who own more than one robot. Currently such tasks are offered via phone support and service staff which travels abroad. They want to expand their service activities on telemaintenance and struggle with the high demands of teleoperation especially regarding security infrastructure. In addition, the facility in Marktheidenfeld has to keep up with the high international standards of Procter & Gamble and wants to minimize machine downtimes. Like 71.6 % of all German companies, P&G sees a huge potential for early information on their production system, but complains about the insufficient quality and the lack of currentness of data. The main research focus of this work lies on the human machine interface for all human tasks in a telemaintenance setup. This thesis provides own work in the use of a mobile device in context of maintenance, describes new tools on asynchronous remote analysis and puts all parts together in an integrated telemaintenance infrastructure. With the help of Augmented Reality, the user performance and satisfaction could be raised. A special regard is put upon the situation awareness of the remote expert realized by different camera viewpoints. In detail the work consists of: - Support of maintenance tasks with a mobile device - Development and evaluation of a context-aware inspection tool - Comparison of a new touch-based mobile robot programming device to the former teach pendant - Study on Augmented Reality support for repair tasks with a mobile device - Condition monitoring for a specific plant with industrial robot - Human computer interaction for remote analysis of a single plant cycle - A big data analysis tool for a multitude of cycles and similar plants - 3D process visualization for a specific plant cycle with additional virtual information - Network architecture in hardware, software and network infrastructure - Mobile device computer supported collaborative work for telemaintenance - Motor exchange telemaintenance example in running production environment - Augmented reality supported remote plant visualization for better situation awareness N2 - Die Fernsteuerung technisch hochentwickelter Systeme ist seit vielen Jahren ein breites Forschungsfeld, vor allem im Bereich von Weltraum- und Robotikanwendungen. Allerdings hat die Automatisierungsindustrie bislang zu wenig von den Ergebnissen dieses Forschungsgebiets profitiert. Auch Fertigungslinien mit Industrierobotern und weiterer Anlagenkomponenten müssen über die Ferne zugänglich sein, besonders bei Wartungsfällen oder wenn unvorhergesehene Probleme nicht von den lokalen Spezialisten gelöst werden können. Hersteller von Sondermaschinen wie Robotikfirmen verkaufen ihre Technologie weltweit. Kunden dieser Firmen besitzen beispielsweise Fabriken in Schwellenländern, wo es an qualifizierten Personal für Reparatur und Wartung mangelt. Wenn ein ernster Fehler auftaucht, muss daher ein Experte des Sondermaschinenherstellers zum Kunden fliegen. Das führt zu langen Stillstandzeiten der Maschine. Durch die Weiterentwicklung der Datennetze könnte ein großer Teil dieser Reisen unterbleiben, wenn eine passende Fernwartungsinfrastruktur vorliegen würde. Diese Arbeit beschreibt die Entwicklung eines Fernwartungssystems, welches in einer aktiven Produktionsumgebung für Forschungszwecke eingerichtet wurde. Die Fertigungsanlage des Kunden wurde von Procter & Gamble in Marktheidenfeld zur Verfügung gestellt und besteht aus einem sechsachsigen, kartesischen Industrieroboter von KUKA Industries, einer Zweikomponentenspritzgussanlage und einer Montageeinheit. Die Anlage produziert Plastikteile für elektrische Zahnbürsten. Diese Anlage wurde im Rahmen der Forschungsprojekte "MainTelRob" und "Bayern.digital" verwendet, in denen das Zentrum für Telematik e.V. (ZfT) und seine Projektpartner neue Ansätze und Prozeduren für moderne Fernwartungs-Technologien entwickeln. Fernwartung bedeutet für uns die umfassende Integration von Informatik und Kommunikationstechnologien in der Wartungsstrategie. Das ist vor allem für hochentwickelte, kapitalintensive Güter wie Industrierobotern interessant. Typische Fernwartungsaufgaben sind beispielsweise die Analyse von Roboterfehlermeldungen oder schwierige Reparaturmaßnahmen. Die Service-Abteilung von KUKA Industries ist für die weltweit verteilten Kunden zuständig, die teilweise auch mehr als einen Roboter besitzen. Aktuell werden derartige Aufgaben per Telefonauskunft oder mobilen Servicekräften, die zum Kunden reisen, erledigt. Will man diese komplizierten Aufgaben durch Fernwartung ersetzen um die Serviceaktivitäten auszuweiten muss man mit den hohen Anforderungen von Fernsteuerung zurechtkommen, besonders in Bezug auf Security Infrastruktur. Eine derartige umfassende Herangehensweise an Fernwartung bietet aber auch einen lokalen Mehrwert beim Kunden: Die Fabrik in Marktheidenfeld muss den hohen internationalen Standards von Procter & Gamble folgen und will daher die Stillstandzeiten weiter verringern. Wie 71,6 Prozent aller deutschen Unternehmen sieht auch P&G Marktheidenfeld ein großes Potential für frühe Informationen aus ihrem Produktionssystem, haben aber aktuell noch Probleme mit der Aktualität und Qualität dieser Daten. Der Hauptfokus der hier vorgestellten Forschung liegt auf der Mensch-Maschine-Schnittstelle für alle Aufgaben eines umfassenden Fernwartungskontextes. Diese Arbeit stellt die eigene Arbeiten bei der Verwendung mobiler Endgeräte im Kontext der Wartung und neue Softwarewerkzeuge für die asynchrone Fernanalyse vor und integriert diese Aspekte in eine Fernwartungsinfrastruktur. In diesem Kontext kann gezeigt werden, dass der Einsatz von Augmented Reality die Nutzerleistung und gleichzeitig die Zufriedenheit steigern kann. Dabei wird auf das sogenannte "situative Bewusstsein" des entfernten Experten besonders Wert gelegt. Im Detail besteht die Arbeit aus: - Unterstützung von Wartungsaufgaben mit mobilen Endgeräten - Entwicklung und Evaluation kontextsensitiver Inspektionssoftware - Vergleich von touch-basierten Roboterprogrammierung mit der Vorgängerversion des Programmierhandgeräts - Studien über die Unterstützung von Reparaturaufgaben durch Augmented Reality - Zustandsüberwachung für eine spezielle Anlage mit Industrieroboter - Mensch-Maschine Interaktion für die Teleanalyse eines Produktionszyklus - Grafische Big Data Analyse einer Vielzahl von Produktionszyklen - 3D Prozess Visualisierung und Anreicherung mit virtuellen Informationen - Hardware, Software und Netzwerkarchitektur für die Fernwartung - Computerunterstützte Zusammenarbeit mit Verwendung mobiler Endgeräte für die Fernwartung - Fernwartungsbeispiel: Durchführung eines Motortauschs in der laufenden Produktion - Augmented Reality unterstütze Visualisierung des Anlagenkontextes für die Steigerung des situativen Bewusstseins T3 - Forschungsberichte in der Robotik = Research Notes in Robotics - 13 KW - Fernwartung KW - Robotik KW - Mensch-Maschine-Schnittstelle KW - Erweiterte Realität KW - Situation Awareness KW - Industrie 4.0 KW - Industrial internet Y1 - 2017 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-150520 SN - 978-3-945459-18-8 ER - TY - JOUR A1 - Andronic, Joseph A1 - Shirakashi, Ryo A1 - Pickel, Simone U. A1 - Westerling, Katherine M. A1 - Klein, Teresa A1 - Holm, Thorge A1 - Sauer, Markus A1 - Sukhorukov, Vladimir L. T1 - Hypotonic Activation of the Myo-Inositol Transporter SLC5A3 in HEK293 Cells Probed by Cell Volumetry, Confocal and Super-Resolution Microscopy JF - PLoS One N2 - Swelling-activated pathways for myo-inositol, one of the most abundant organic osmolytes in mammalian cells, have not yet been identified. The present study explores the SLC5A3 protein as a possible transporter of myo-inositol in hyponically swollen HEK293 cells. To address this issue, we examined the relationship between the hypotonicity-induced changes in plasma membrane permeability to myo-inositol Pino [m/s] and expression/localization of SLC5A3. Pino values were determined by cell volumetry over a wide tonicity range (100–275 mOsm) in myo-inositol-substituted solutions. While being negligible under mild hypotonicity (200–275 mOsm), Pino grew rapidly at osmolalities below 200 mOsm to reach a maximum of ∼3 nm/s at 100–125 mOsm, as indicated by fast cell swelling due to myo-inositol influx. The increase in Pino resulted most likely from the hypotonicity-mediated incorporation of cytosolic SLC5A3 into the plasma membrane, as revealed by confocal fluorescence microscopy of cells expressing EGFP-tagged SLC5A3 and super-resolution imaging of immunostained SLC5A3 by direct stochastic optical reconstruction microscopy (dSTORM). dSTORM in hypotonic cells revealed a surface density of membrane-associated SLC5A3 proteins of 200–2000 localizations/μm2. Assuming SLC5A3 to be the major path for myo-inositol, a turnover rate of 80–800 myo-inositol molecules per second for a single transporter protein was estimated from combined volumetric and dSTORM data. Hypotonic stress also caused a significant upregulation of SLC5A3 gene expression as detected by semiquantitative RT-PCR and Western blot analysis. In summary, our data provide first evidence for swelling-mediated activation of SLC5A3 thus suggesting a functional role of this transporter in hypotonic volume regulation of mammalian cells. KW - electrolytes KW - isotonic KW - membrane proteins KW - cell membranes KW - hypotonic KW - hypotonic solutions KW - tonicity KW - permeability Y1 - 2015 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-126408 VL - 10 IS - 3 ER - TY - JOUR A1 - Weiß, Clemens Leonard A1 - Schultz, Jörg T1 - Identification of divergent WH2 motifs by HMM-HMM alignments JF - BMC Research Notes N2 - Background The actin cytoskeleton is a hallmark of eukaryotic cells. Its regulation as well as its interaction with other proteins is carefully orchestrated by actin interaction domains. One of the key players is the WH2 motif, which enables binding to actin monomers and filaments and is involved in the regulation of actin nucleation. Contrasting conserved domains, the identification of this motif in protein sequences is challenging, as it is short and poorly conserved. Findings To identify divergent members, we combined Hidden-Markov-Model (HMM) to HMM alignments with orthology predictions. Thereby, we identified nearly 500 proteins containing so far not annotated WH2 motifs. This included shootin-1, an actin binding protein involved in neuron polarization. Among others, WH2 motifs of ‘proximal to raf’ (ptr)-orthologs, which are described in the literature, but not annotated in genome databases, were identified. Conclusion In summary, we increased the number of WH2 motif containing proteins substantially. This identification of candidate regions for actin interaction could steer their experimental characterization. Furthermore, the approach outlined here can easily be adapted to the identification of divergent members of further domain families. KW - WH2 domain KW - spire KW - shootin-1 KW - actin nucleation KW - HHblits Y1 - 2015 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-126413 VL - 8 IS - 18 ER - TY - JOUR A1 - Buga, Ana-Maria A1 - Scholz, Claus Jürgen A1 - Kumar, Senthil A1 - Herndon, James G. A1 - Alexandru, Dragos A1 - Cojocaru, Gabriel Radu A1 - Dandekar, Thomas A1 - Popa-Wagner, Aurel T1 - Identification of New Therapeutic Targets by Genome-Wide Analysis of Gene Expression in the Ipsilateral Cortex of Aged Rats after Stroke JF - PLoS One N2 - Background: Because most human stroke victims are elderly, studies of experimental stroke in the aged rather than the young rat model may be optimal for identifying clinically relevant cellular responses, as well for pinpointing beneficial interventions. Methodology/Principal Findings: We employed the Affymetrix platform to analyze the whole-gene transcriptome following temporary ligation of the middle cerebral artery in aged and young rats. The correspondence, heat map, and dendrogram analyses independently suggest a differential, age-group-specific behaviour of major gene clusters after stroke. Overall, the pattern of gene expression strongly suggests that the response of the aged rat brain is qualitatively rather than quantitatively different from the young, i.e. the total number of regulated genes is comparable in the two age groups, but the aged rats had great difficulty in mounting a timely response to stroke. Our study indicates that four genes related to neuropathic syndrome, stress, anxiety disorders and depression (Acvr1c, Cort, Htr2b and Pnoc) may have impaired response to stroke in aged rats. New therapeutic options in aged rats may also include Calcrl, Cyp11b1, Prcp, Cebpa, Cfd, Gpnmb, Fcgr2b, Fcgr3a, Tnfrsf26, Adam 17 and Mmp14. An unexpected target is the enzyme 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 in aged rats, a key enzyme in the cholesterol synthesis pathway. Post-stroke axonal growth was compromised in both age groups. Conclusion/Significance: We suggest that a multi-stage, multimodal treatment in aged animals may be more likely to produce positive results. Such a therapeutic approach should be focused on tissue restoration but should also address other aspects of patient post-stroke therapy such as neuropathic syndrome, stress, anxiety disorders, depression, neurotransmission and blood pressure. KW - gamma KW - corticotropin-releasing hormone KW - colony-stimulating factor KW - cerebral ischemia KW - receptor KW - brain KW - protein KW - inhibitor KW - mouse KW - differentiation Y1 - 2012 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-130657 VL - 7 IS - 12 ER - TY - RPRT A1 - Vomhoff, Viktoria A1 - Geißler, Stefan A1 - Hoßfeld, Tobias T1 - Identification of Signaling Patterns in Mobile IoT Signaling Traffic T2 - Würzburg Workshop on Next-Generation Communication Networks (WueWoWas'22) N2 - We attempt to identify sequences of signaling dialogs, to strengthen our understanding of the signaling behavior of IoT devices by examining a dataset containing over 270.000 distinct IoT devices whose signaling traffic has been observed over a 31-day period in a 2G network [4]. We propose a set of rules that allows the assembly of signaling dialogs into so-called sessions in order to identify common patterns and lay the foundation for future research in the areas of traffic modeling and anomaly detection. KW - Datennetz KW - IoT Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-280819 ER - TY - CHAP A1 - Sanusi, Khaleel Asyraaf Mat A1 - Klemke, Roland T1 - Immersive Multimodal Environments for Psychomotor Skills Training T2 - Proceedings of the 1st Games Technology Summit N2 - Modern immersive multimodal technologies enable the learners to completely get immersed in various learning situations in a way that feels like experiencing an authentic learning environment. These environments also allow the collection of multimodal data, which can be used with artificial intelligence to further improve the immersion and learning outcomes. The use of artificial intelligence has been widely explored for the interpretation of multimodal data collected from multiple sensors, thus giving insights to support learners’ performance by providing personalised feedback. In this paper, we present a conceptual approach for creating immersive learning environments, integrated with multi-sensor setup to help learners improve their psychomotor skills in a remote setting. KW - immersive learning technologies KW - multimodal learning KW - sensor devices KW - artificial intelligence KW - psychomotor training Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-246016 ER - TY - JOUR A1 - Lopez-Arreguin, A. J. R. A1 - Montenegro, S. T1 - Improving engineering models of terramechanics for planetary exploration JF - Results in Engineering N2 - This short letter proposes more consolidated explicit solutions for the forces and torques acting on typical rover wheels, that can be used as a method to determine their average mobility characteristics in planetary soils. The closed loop solutions stand in one of the verified methods, but at difference of the previous, observables are decoupled requiring a less amount of physical parameters to measure. As a result, we show that with knowledge of terrain properties, wheel driving performance rely in a single observable only. Because of their generality, the formulated equations established here can have further implications in autonomy and control of rovers or planetary soil characterization. KW - Wheel KW - Terramechanics KW - Forces KW - Torque KW - Robotics Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-202490 VL - 3 ER - TY - JOUR A1 - Schlör, Daniel A1 - Ring, Markus A1 - Hotho, Andreas T1 - iNALU: Improved Neural Arithmetic Logic Unit JF - Frontiers in Artificial Intelligence N2 - Neural networks have to capture mathematical relationships in order to learn various tasks. They approximate these relations implicitly and therefore often do not generalize well. The recently proposed Neural Arithmetic Logic Unit (NALU) is a novel neural architecture which is able to explicitly represent the mathematical relationships by the units of the network to learn operations such as summation, subtraction or multiplication. Although NALUs have been shown to perform well on various downstream tasks, an in-depth analysis reveals practical shortcomings by design, such as the inability to multiply or divide negative input values or training stability issues for deeper networks. We address these issues and propose an improved model architecture. We evaluate our model empirically in various settings from learning basic arithmetic operations to more complex functions. Our experiments indicate that our model solves stability issues and outperforms the original NALU model in means of arithmetic precision and convergence. KW - neural networks KW - machine learning KW - arithmetic calculations KW - neural architecture KW - experimental evaluation Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-212301 SN - 2624-8212 VL - 3 ER - TY - JOUR A1 - Glémarec, Yann A1 - Lugrin, Jean-Luc A1 - Bosser, Anne-Gwenn A1 - Collins Jackson, Aryana A1 - Buche, Cédric A1 - Latoschik, Marc Erich T1 - Indifferent or Enthusiastic? Virtual Audiences Animation and Perception in Virtual Reality JF - Frontiers in Virtual Reality N2 - In this paper, we present a virtual audience simulation system for Virtual Reality (VR). The system implements an audience perception model controlling the nonverbal behaviors of virtual spectators, such as facial expressions or postures. Groups of virtual spectators are animated by a set of nonverbal behavior rules representing a particular audience attitude (e.g., indifferent or enthusiastic). Each rule specifies a nonverbal behavior category: posture, head movement, facial expression and gaze direction as well as three parameters: type, frequency and proportion. In a first user-study, we asked participants to pretend to be a speaker in VR and then create sets of nonverbal behaviour parameters to simulate different attitudes. Participants manipulated the nonverbal behaviours of single virtual spectator to match a specific levels of engagement and opinion toward them. In a second user-study, we used these parameters to design different types of virtual audiences with our nonverbal behavior rules and evaluated their perceptions. Our results demonstrate our system’s ability to create virtual audiences with three types of different perceived attitudes: indifferent, critical, enthusiastic. The analysis of the results also lead to a set of recommendations and guidelines regarding attitudes and expressions for future design of audiences for VR therapy and training applications. KW - virtual reality KW - perception KW - nonverbal behavior KW - interaction KW - virtual agent KW - virtual audience Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-259328 VL - 2 ER - TY - JOUR A1 - Li, Ningbo A1 - Guan, Lianwu A1 - Gao, Yanbin A1 - Du, Shitong A1 - Wu, Menghao A1 - Guang, Xingxing A1 - Cong, Xiaodan T1 - Indoor and outdoor low-cost seamless integrated navigation system based on the integration of INS/GNSS/LIDAR system JF - Remote Sensing N2 - Global Navigation Satellite System (GNSS) provides accurate positioning data for vehicular navigation in open outdoor environment. In an indoor environment, Light Detection and Ranging (LIDAR) Simultaneous Localization and Mapping (SLAM) establishes a two-dimensional map and provides positioning data. However, LIDAR can only provide relative positioning data and it cannot directly provide the latitude and longitude of the current position. As a consequence, GNSS/Inertial Navigation System (INS) integrated navigation could be employed in outdoors, while the indoors part makes use of INS/LIDAR integrated navigation and the corresponding switching navigation will make the indoor and outdoor positioning consistent. In addition, when the vehicle enters the garage, the GNSS signal will be blurred for a while and then disappeared. Ambiguous GNSS satellite signals will lead to the continuous distortion or overall drift of the positioning trajectory in the indoor condition. Therefore, an INS/LIDAR seamless integrated navigation algorithm and a switching algorithm based on vehicle navigation system are designed. According to the experimental data, the positioning accuracy of the INS/LIDAR navigation algorithm in the simulated environmental experiment is 50% higher than that of the Dead Reckoning (DR) algorithm. Besides, the switching algorithm developed based on the INS/LIDAR integrated navigation algorithm can achieve 80% success rate in navigation mode switching. KW - vehicular navigation KW - GNSS/INS integrated navigation KW - INS/LIDAR integrated navigation KW - switching navigation Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-216229 SN - 2072-4292 VL - 12 IS - 19 ER - TY - JOUR A1 - Riedmann, Anna A1 - Schaper, Philipp A1 - Lugrin, Birgit T1 - Integration of a social robot and gamification in adult learning and effects on motivation, engagement and performance JF - AI & Society N2 - Learning is a central component of human life and essential for personal development. Therefore, utilizing new technologies in the learning context and exploring their combined potential are considered essential to support self-directed learning in a digital age. A learning environment can be expanded by various technical and content-related aspects. Gamification in the form of elements from video games offers a potential concept to support the learning process. This can be supplemented by technology-supported learning. While the use of tablets is already widespread in the learning context, the integration of a social robot can provide new perspectives on the learning process. However, simply adding new technologies such as social robots or gamification to existing systems may not automatically result in a better learning environment. In the present study, game elements as well as a social robot were integrated separately and conjointly into a learning environment for basic Spanish skills, with a follow-up on retained knowledge. This allowed us to investigate the respective and combined effects of both expansions on motivation, engagement and learning effect. This approach should provide insights into the integration of both additions in an adult learning context. We found that the additions of game elements and the robot did not significantly improve learning, engagement or motivation. Based on these results and a literature review, we outline relevant factors for meaningful integration of gamification and social robots in learning environments in adult learning. KW - social robot KW - gamification KW - technology-supported learning KW - adult learning Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-324208 SN - 0951-5666 ER - TY - THES A1 - Ostermayer, Ludwig T1 - Integration of Prolog and Java with the Connector Architecture CAPJa T1 - Integration von Prolog und Java mit Hilfe der Connector Architecture CAPJa N2 - Modern software is often realized as a modular combination of subsystems for, e. g., knowledge management, visualization, verification, or the interaction with users. As a result, software libraries from possibly different programming languages have to work together. Even more complex the case is if different programming paradigms have to be combined. This type of diversification of programming languages and paradigms in just one software application can only be mastered by mechanisms for a seamless integration of the involved programming languages. However, the integration of the common logic programming language Prolog and the popular object-oriented programming language Java is complicated by various interoperability problems which stem on the one hand from the paradigmatic gap between the programming languages, and on the other hand, from the diversity of the available Prolog systems. The subject of the thesis is the investigation of novel mechanisms for the integration of logic programming in Prolog and object–oriented programming in Java. We are particularly interested in an object–oriented, uniform approach which is not specific to just one Prolog system. Therefore, we have first identified several important criteria for the seamless integration of Prolog and Java from the object–oriented perspective. The main contribution of the thesis is a novel integration framework called the Connector Architecture for Prolog and Java (CAPJa). The framework is completely implemented in Java and imposes no modifications to the Java Virtual Machine or Prolog. CAPJa provides a semi–automated mechanism for the integration of Prolog predicates into Java. For compact, readable, and object–oriented queries to Prolog, CAPJa exploits lambda expressions with conditional and relational operators in Java. The communication between Java and Prolog is based on a fully automated mapping of Java objects to Prolog terms, and vice versa. In Java, an extensible system of gateways provides connectivity with various Prolog system and, moreover, makes any connected Prolog system easily interchangeable, without major adaption in Java. N2 - Moderne Software ist oft modular zusammengesetzt aus Subsystemen zur Wissensverwaltung, Visualisierung, Verfikation oder Benutzerinteraktion. Dabei müssen Programmbibliotheken aus möglicherweise verschiedenen Programmiersprachen miteinander zusammenarbeiten. Noch komplizierter ist der Fall, wenn auch noch verschiedene Programmierparadigmen miteinander kombiniert werden. Diese Art der Diversifikation an Programmiersprachen und –paradigmen in nur einer Software kann nur von nahtlosen Integrationsmechansimen für die beteiligten Programmiersprachen gemeistert werden. Gerade die Einbindung der gängigen Logikprogrammiersprache Prolog und der populären objektorientierten Programmiersprache Java wird durch zahlreiche Kompatibilitätsprobleme erschwert, welche auf der einen Seite von paradigmatischen Unterschieden der beiden Programmiersprachen herrühren und auf der anderen Seite von der Vielfalt der erhältlichen Prologimplementierungen. Gegenstand dieser Arbeit ist die Untersuchung von neuartigen Mechanismen für die Zusammenführung von Logikprogrammierung in Prolog und objektorienter Programmierung in Java. Besonders interessiert uns dabei ein objektorientierter, einheitlicher Ansatz, der nicht auf eine konkrete Prologimplementierung festgelegt ist. Aus diesem Grund haben wir zunächst wichtige Kriterien für die nahtlose Integration von Prolog und Java aus der objetorientierten Sicht identifziert. Der Hauptbeitrag dieser Arbeit ist ein neuartiges Integrationssystems, welches Connector Architecture for Prolog and Java (CAPJa) heißt. Das System ist komplett in Java implementiert und benötigt keine Anpassungen der Java Virtual Machine oder Prolog. CAPJa stellt einen halbautomatischen Mechanismus zur Vernetzung von Prolog Prädikaten mit Java zur Verfügung. Für kompakte, lesbare und objektorientierte Anfragen an Prolog nutzt CAPJa Lambdaausdrücke mit logischen und relationalen Operatoren in Java. Die Kommunikation zwischen Java und Prolog basiert auf einer automatisierten Abbildung von Java Objekten auf Prolog Terme, und umgekehrt. In Java bietet ein erweiterbares System von Schnittstellen Konnektivität zu einer Vielzahl an Prologimplmentierung und macht darüber hinaus jede verbundene Prologimplementierung einfach austauschbar, und zwar ohne größere Anpassung in Java. KW - Logische Programmierung KW - Objektorientierte Programmierung KW - PROLOG KW - Java KW - Multi-Paradigm Programming KW - Logic Programming KW - Object-Oriented Programming KW - Multi-Paradigm Programming Framework Y1 - 2017 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-150713 ER - TY - JOUR A1 - Hein, Rebecca M. A1 - Latoschik, Marc Erich A1 - Wienrich, Carolin T1 - Inter- and transcultural learning in cocial virtual reality: a proposal for an inter- and transcultural virtual object database to be used in the implementation, reflection, and evaluation of virtual encounters JF - Multimodal Technologies and Interaction N2 - Visual stimuli are frequently used to improve memory, language learning or perception, and understanding of metacognitive processes. However, in virtual reality (VR), there are few systematically and empirically derived databases. This paper proposes the first collection of virtual objects based on empirical evaluation for inter-and transcultural encounters between English- and German-speaking learners. We used explicit and implicit measurement methods to identify cultural associations and the degree of stereotypical perception for each virtual stimuli (n = 293) through two online studies, including native German and English-speaking participants. The analysis resulted in a final well-describable database of 128 objects (called InteractionSuitcase). In future applications, the objects can be used as a great interaction or conversation asset and behavioral measurement tool in social VR applications, especially in the field of foreign language education. For example, encounters can use the objects to describe their culture, or teachers can intuitively assess stereotyped attitudes of the encounters. KW - virtual stimuli KW - implicit association test KW - virtual reality KW - social VR KW - InteractionSuitcase Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-278974 SN - 2414-4088 VL - 6 IS - 7 ER - TY - JOUR A1 - Hurtienne, Jörn T1 - Inter-coder reliability of categorising force-dynamic events in human-technology interaction N2 - Two studies are reported that investigate how readily accessible and applicable ten force-dynamic categories are to novices in describing short episodes of human-technology interaction (Study 1) and that establish a measure of inter-coder reliability when re-classifying these episodes into force-dynamic categories (Study 2). The results of the first study show that people can easily and confidently relate their experiences with technology to the definitions of force-dynamic events (e.g. “The driver released the handbrake” as an example of restraint removal). The results of the second study show moderate agreement between four expert coders across all ten force-dynamic categories (Cohen’s kappa = .59) when re-classifying these episodes. Agreement values for single force-dynamic categories ranged between ‘fair’ and ‘almost perfect’, i.e. between kappa = .30 and .95. Agreement with the originally intended classifications of study 1 was higher than the pure inter-coder reliabilities. Single coders achieved an average kappa of .71, indicating substantial agreement. Using more than one coder increased kappas to almost perfect: up to .87 for four coders. A qualitative analysis of the predicted versus the observed number of category confusions revealed that about half of the category disagreement could be predicted from strong overlaps in the definitions of force-dynamic categories. From the quantitative and qualitative results, guidelines are derived to aid the better training of coders in order to increase inter-coder reliability. KW - inter-coder reliability KW - force dynamics KW - image schemas KW - humantechnology interaction Y1 - 2013 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-194127 SN - 2197-2796 SN - 2197-2788 N1 - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively. VL - 1 IS - 1 ER - TY - CHAP A1 - Truman, Samuel A1 - von Mammen, Sebastian T1 - Interactive Self-Assembling Agent Ensembles T2 - Proceedings of the 1st Games Technology Summit N2 - In this paper, we bridge the gap between procedural content generation (PCG) and user-generated content (UGC) by proposing and demonstrating an interactive agent-based model of self-assembling ensembles that can be directed though user input. We motivate these efforts by considering the opportunities technology provides to pursue game designs based on according game design frameworks. We present three different use cases of the proposed model that emphasize its potential to (1) self-assemble into predefined 3D graphical assets, (2) define new structures in the context of virtual environments by self-assembling layers on the surfaces of arbitrary 3D objects, and (3) allow novel structures to self-assemble only considering the model’s configuration and no external dependencies. To address the performance restrictions in computer games, we realized the prototypical model implementation by means of an efficient entity component system (ECS). We conclude the paper with an outlook on future steps to further explore novel interactive, dynamic PCG mechanics and to ensure their efficiency. KW - procedural content generation KW - user-generated content KW - game mechanics KW - agent-based models KW - self-assembly Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-246032 ER - TY - JOUR A1 - von Mammen, Sebastian Albrecht A1 - Wagner, Daniel A1 - Knote, Andreas A1 - Taskin, Umut T1 - Interactive simulations of biohybrid systems JF - Frontiers in Robotics and AI N2 - In this article, we present approaches to interactive simulations of biohybrid systems. These simulations are comprised of two major computational components: (1) agent-based developmental models that retrace organismal growth and unfolding of technical scaffoldings and (2) interfaces to explore these models interactively. Simulations of biohybrid systems allow us to fast forward and experience their evolution over time based on our design decisions involving the choice, configuration and initial states of the deployed biological and robotic actors as well as their interplay with the environment. We briefly introduce the concept of swarm grammars, an agent-based extension of L-systems for retracing growth processes and structural artifacts. Next, we review an early augmented reality prototype for designing and projecting biohybrid system simulations into real space. In addition to models that retrace plant behaviors, we specify swarm grammar agents to braid structures in a self-organizing manner. Based on this model, both robotic and plant-driven braiding processes can be experienced and explored in virtual worlds. We present an according user interface for use in virtual reality. As we present interactive models concerning rather diverse description levels, we only ensured their principal capacity for interaction but did not consider efficiency analyzes beyond prototypic operation. We conclude this article with an outlook on future works on melding reality and virtuality to drive the design and deployment of biohybrid systems. KW - biohybrid systems KW - augmented reality KW - virtual reality KW - user interfaces KW - biological development KW - generative systems Y1 - 2017 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-195755 SN - 2296-9144 VL - 4 ER - TY - JOUR A1 - Prakash, Subash A1 - Unnikrishnan, Vishnu A1 - Pryss, Rüdiger A1 - Kraft, Robin A1 - Schobel, Johannes A1 - Hannemann, Ronny A1 - Langguth, Berthold A1 - Schlee, Winfried A1 - Spiliopoulou, Myra T1 - Interactive system for similarity-based inspection and assessment of the well-being of mHealth users JF - Entropy N2 - Recent digitization technologies empower mHealth users to conveniently record their Ecological Momentary Assessments (EMA) through web applications, smartphones, and wearable devices. These recordings can help clinicians understand how the users' condition changes, but appropriate learning and visualization mechanisms are required for this purpose. We propose a web-based visual analytics tool, which processes clinical data as well as EMAs that were recorded through a mHealth application. The goals we pursue are (1) to predict the condition of the user in the near and the far future, while also identifying the clinical data that mostly contribute to EMA predictions, (2) to identify users with outlier EMA, and (3) to show to what extent the EMAs of a user are in line with or diverge from those users similar to him/her. We report our findings based on a pilot study on patient empowerment, involving tinnitus patients who recorded EMAs with the mHealth app TinnitusTips. To validate our method, we also derived synthetic data from the same pilot study. Based on this setting, results for different use cases are reported. KW - medical analytics KW - condition prediction KW - ecological momentary assessment KW - visual analytics KW - time series Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-252333 SN - 1099-4300 VL - 23 IS - 12 ER - TY - JOUR A1 - Buchheim, Mark A. A1 - Keller, Alexander A1 - Koetschan, Christian A1 - Förster, Frank A1 - Merget, Benjamin A1 - Wolf, Matthias T1 - Internal Transcribed Spacer 2 (nu ITS2 rRNA) Sequence-Structure Phylogenetics: Towards an Automated Reconstruction of the Green Algal Tree of Life JF - PLoS ONE N2 - Background: Chloroplast-encoded genes (matK and rbcL) have been formally proposed for use in DNA barcoding efforts targeting embryophytes. Extending such a protocol to chlorophytan green algae, though, is fraught with problems including non homology (matK) and heterogeneity that prevents the creation of a universal PCR toolkit (rbcL). Some have advocated the use of the nuclear-encoded, internal transcribed spacer two (ITS2) as an alternative to the traditional chloroplast markers. However, the ITS2 is broadly perceived to be insufficiently conserved or to be confounded by introgression or biparental inheritance patterns, precluding its broad use in phylogenetic reconstruction or as a DNA barcode. A growing body of evidence has shown that simultaneous analysis of nucleotide data with secondary structure information can overcome at least some of the limitations of ITS2. The goal of this investigation was to assess the feasibility of an automated, sequence-structure approach for analysis of IT2 data from a large sampling of phylum Chlorophyta. Methodology/Principal Findings: Sequences and secondary structures from 591 chlorophycean, 741 trebouxiophycean and 938 ulvophycean algae, all obtained from the ITS2 Database, were aligned using a sequence structure-specific scoring matrix. Phylogenetic relationships were reconstructed by Profile Neighbor-Joining coupled with a sequence structure-specific, general time reversible substitution model. Results from analyses of the ITS2 data were robust at multiple nodes and showed considerable congruence with results from published phylogenetic analyses. Conclusions/Significance: Our observations on the power of automated, sequence-structure analyses of ITS2 to reconstruct phylum-level phylogenies of the green algae validate this approach to assessing diversity for large sets of chlorophytan taxa. Moreover, our results indicate that objections to the use of ITS2 for DNA barcoding should be weighed against the utility of an automated, data analysis approach with demonstrated power to reconstruct evolutionary patterns for highly divergent lineages. KW - RBCL Gene-sequences KW - Colonial volvocales chlorophyta KW - 26S RDNA Data KW - Land plants KW - Molecular systematics KW - Secondary structure KW - Nuclear RDNA KW - DNA KW - Barcodes KW - Dasycladales chlorophyta KW - Profile distances Y1 - 2011 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-140866 VL - 6 IS - 2 ER - TY - THES A1 - Zeiger, Florian T1 - Internet Protocol based networking of mobile robots T1 - Internet Protokoll basierte Vernetzung von mobilen Robotern N2 - This work is composed of three main parts: remote control of mobile systems via Internet, ad-hoc networks of mobile robots, and remote control of mobile robots via 3G telecommunication technologies. The first part gives a detailed state of the art and a discussion of the problems to be solved in order to teleoperate mobile robots via the Internet. The focus of the application to be realized is set on a distributed tele-laboratory with remote experiments on mobile robots which can be accessed world-wide via the Internet. Therefore, analyses of the communication link are used in order to realize a robust system. The developed and implemented architecture of this distributed tele-laboratory allows for a smooth access also with a variable or low link quality. The second part covers the application of ad-hoc networks for mobile robots. The networking of mobile robots via mobile ad-hoc networks is a very promising approach to realize integrated telematic systems without relying on preexisting communication infrastructure. Relevant civilian application scenarios are for example in the area of search and rescue operations where first responders are supported by multi-robot systems. Here, mobile robots, humans, and also existing stationary sensors can be connected very fast and efficient. Therefore, this work investigates and analyses the performance of different ad-hoc routing protocols for IEEE 802.11 based wireless networks in relevant scenarios. The analysis of the different protocols allows for an optimization of the parameter settings in order to use these ad-hoc routing protocols for mobile robot teleoperation. Also guidelines for the realization of such telematics systems are given. Also traffic shaping mechanisms of application layer are presented which allow for a more efficient use of the communication link. An additional application scenario, the integration of a small size helicopter into an IP based ad-hoc network, is presented. The teleoperation of mobile robots via 3G telecommunication technologies is addressed in the third part of this work. The high availability, high mobility, and the high bandwidth provide a very interesting opportunity to realize scenarios for the teleoperation of mobile robots or industrial remote maintenance. This work analyses important parameters of the UMTS communication link and investigates also the characteristics for different data streams. These analyses are used to give guidelines which are necessary for the realization of or industrial remote maintenance or mobile robot teleoperation scenarios. All the results and guidelines for the design of telematic systems in this work were derived from analyses and experiments with real hardware. N2 - Diese Arbeit gliedert sich in drei Hauptteile: Fernsteuerung mobiler Systeme über das Internet, ad-hoc Netzwerke mobiler Roboter und Fernsteuerung mobiler Roboter über Mobilfunktechnologien der 3. Generation. Im ersten Teil werden ein ausführlicher Stand der Technik und eine Diskussion der bei der Fernsteuerung mobiler Roboter über das Internet zu lösenden Probleme gegeben. Der Fokus der zu realisierenden Anwendung in diesem Teil der Arbeit liegt auf einem verteilten Tele-Labor mit Experimenten zu mobilen Robotern, welche über das Internet weltweit zugänglich sind. Hierzu werden Link-Analysen der zugrundeliegenden Kommunikationsinfrastruktur zu Hilfe genommen, um ein robustes System zu realisieren. Die entwickelte und implementierte Architektur des verteilten Tele-Labors erlaubt einen reibungslosen Zugang auch für Verbindungen mit variabler oder schlechter Linkqualität. Im zweiten Teil werden ad-hoc Netzwerke mobiler Roboter behandelt. Die Vernetzung mobiler Roboter über mobile ad-hoc Netzwerke ist eine vielversprechende Möglichkeit um integrierte Telematiksysteme zu realisieren ohne auf zuvor existierende Infrastruktur angewiesen zu sein. Relevante Einsatzszenarien im zivilen Bereich sind zum Beispiel Such- und Rettungsszenarien, in denen die Rettungskräfte vor Ort durch vernetzte Multi-Roboter Systeme unterstütz werden. Hier werden dann mobile Roboter, Menschen und gegebenenfalls auch vorhandene stationäre Sensoren schnell und effizient vernetzt. In dieser Arbeit werden dazu verschieden ad-hoc Routing-Protokolle für IEEE 802.11 basierte Drahtlosnetzwerke in relevanten Szenarien untersucht und deren Leistungsfähigkeit verglichen. Die Analyse der verschiedenen Protokolle erlaubt eine Optimierung der Parametereinstellung, um diese ad-hoc Routing-Protokolle zur Fernsteuerung mobiler Roboter nutzbar zu machen. Weiterhin werden Richtlinien zur Realisierung solcher Telematiksysteme erarbeitet und Mechanismen zur Verkehrsformung auf Applikationsebene präsentiert, die eine effizientere Nutzung der vorhandenen Kommunikationskanäle erlauben. Als weiteres Anwendungsbeispiel ist die Integration eines ferngesteuerten Kleinhubschraubers in ein IP basiertes ad-hoc Netz beschrieben. Der dritte Teil der Arbeit beschäftigt sich mit der Fernsteuerung mobiler Roboter über Mobilfunktechnologien der 3. Generation. Die hohe Verfügbarkeit der UMTS-Technologie mit der verbundenen Mobilität und der gleichzeitigen hohen Bandbreite bietet hier eine interessante Möglichkeit um die Fernsteuerung mobiler Roboter oder auch interaktive Fernwartungsszenarien zu realisieren. In der vorliegenden Arbeit werden wichtige Parameter der UMTS Verbindung analysiert und auch die Charakteristiken der Verbindung für verschiedene Verkehrsströme ermittelt. Diese dienen dann zur Erstellung von Richtlinien, die zur Umsetzung der interaktive Fernwartungsszenarien oder auch der Fernsteuerung mobiler Roboter nötig sind. Die in dieser Arbeit erstellten Richtlinien zum Entwurf von Telematiksystemen wurden aus Analysen und Experimenten mit realer Hardware abgeleitet. T3 - Forschungsberichte in der Robotik = Research Notes in Robotics - 4 KW - Robotik KW - Mobiler Roboter KW - Fernsteuerung KW - vernetzte Roboter KW - Telematik KW - Fernsteuerung KW - Robotik KW - Internet Protokoll KW - networked robotics KW - telematics KW - remote control KW - robotics KW - internet protocol Y1 - 2010 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-54776 SN - 978-3-923959-59-4 ER - TY - JOUR A1 - Krupitzer, Christian A1 - Eberhardinger, Benedikt A1 - Gerostathopoulos, Ilias A1 - Raibulet, Claudia T1 - Introduction to the special issue “Applications in Self-Aware Computing Systems and their Evaluation” JF - Computers N2 - The joint 1st Workshop on Evaluations and Measurements in Self-Aware Computing Systems (EMSAC 2019) and Workshop on Self-Aware Computing (SeAC) was held as part of the FAS* conference alliance in conjunction with the 16th IEEE International Conference on Autonomic Computing (ICAC) and the 13th IEEE International Conference on Self-Adaptive and Self-Organizing Systems (SASO) in Umeå, Sweden on 20 June 2019. The goal of this one-day workshop was to bring together researchers and practitioners from academic environments and from the industry to share their solutions, ideas, visions, and doubts in self-aware computing systems in general and in the evaluation and measurements of such systems in particular. The workshop aimed to enable discussions, partnerships, and collaborations among the participants. This special issue follows the theme of the workshop. It contains extended versions of workshop presentations as well as additional contributions. KW - self-aware computing systems KW - quality evaluation KW - measurements KW - quality assurance KW - autonomous KW - self-adaptive KW - self-managing systems Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-203439 SN - 2073-431X VL - 9 IS - 1 ER - TY - INPR A1 - Nassourou, Mohamadou T1 - Java Web Frameworks Which One to Choose? N2 - This article discusses web frameworks that are available to a software developer in Java language. It introduces MVC paradigm and some frameworks that implement it. The article presents an overview of Struts, Spring MVC, JSF Frameworks, as well as guidelines for selecting one of them as development environment. KW - Java Frameworks KW - MVC KW - Struts KW - Spring KW - JSF Y1 - 2010 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-49407 ER - TY - RPRT A1 - Rauber, Christof A. O. A1 - Brechtel, Lukas A1 - Schotten, Hans D. T1 - JCAS-Enabled Sensing as a Service in 6th-Generation Mobile Communication Networks T2 - KuVS Fachgespräch - Würzburg Workshop on Modeling, Analysis and Simulation of Next-Generation Communication Networks 2023 (WueWoWAS’23) N2 - The introduction of new types of frequency spectrum in 6G technology facilitates the convergence of conventional mobile communications and radar functions. Thus, the mobile network itself becomes a versatile sensor system. This enables mobile network operators to offer a sensing service in addition to conventional data and telephony services. The potential benefits are expected to accrue to various stakeholders, including individuals, the environment, and society in general. The paper discusses technological development, possible integration, and use cases, as well as future development areas. KW - Sensing-aaS KW - JCAS KW - 6G Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-322135 ER - TY - JOUR A1 - Karl, Stefan A1 - Dandekar, Thomas T1 - Jimena: Efficient computing and system state identification for genetic regulatory networks JF - BMC Bioinformatics N2 - Background: Boolean networks capture switching behavior of many naturally occurring regulatory networks. For semi-quantitative modeling, interpolation between ON and OFF states is necessary. The high degree polynomial interpolation of Boolean genetic regulatory networks (GRNs) in cellular processes such as apoptosis or proliferation allows for the modeling of a wider range of node interactions than continuous activator-inhibitor models, but suffers from scaling problems for networks which contain nodes with more than ~10 inputs. Many GRNs from literature or new gene expression experiments exceed those limitations and a new approach was developed. Results: (i) As a part of our new GRN simulation framework Jimena we introduce and setup Boolean-tree-based data structures; (ii) corresponding algorithms greatly expedite the calculation of the polynomial interpolation in almost all cases, thereby expanding the range of networks which can be simulated by this model in reasonable time. (iii) Stable states for discrete models are efficiently counted and identified using binary decision diagrams. As application example, we show how system states can now be sampled efficiently in small up to large scale hormone disease networks (Arabidopsis thaliana development and immunity, pathogen Pseudomonas syringae and modulation by cytokinins and plant hormones). Conclusions: Jimena simulates currently available GRNs about 10-100 times faster than the previous implementation of the polynomial interpolation model and even greater gains are achieved for large scale-free networks. This speed-up also facilitates a much more thorough sampling of continuous state spaces which may lead to the identification of new stable states. Mutants of large networks can be constructed and analyzed very quickly enabling new insights into network robustness and behavior. KW - Boolean function KW - genetic regulatory network KW - interpolation KW - stable state KW - binary decision diagram KW - Boolean tree Y1 - 2013 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-128671 VL - 14 ER - TY - JOUR A1 - Landeck, Maximilian A1 - Alvarez Igarzábal, Federico A1 - Unruh, Fabian A1 - Habenicht, Hannah A1 - Khoshnoud, Shiva A1 - Wittmann, Marc A1 - Lugrin, Jean-Luc A1 - Latoschik, Marc Erich T1 - Journey through a virtual tunnel: Simulated motion and its effects on the experience of time JF - Frontiers in Virtual Reality N2 - This paper examines the relationship between time and motion perception in virtual environments. Previous work has shown that the perception of motion can affect the perception of time. We developed a virtual environment that simulates motion in a tunnel and measured its effects on the estimation of the duration of time, the speed at which perceived time passes, and the illusion of self-motion, also known as vection. When large areas of the visual field move in the same direction, vection can occur; observers often perceive this as self-motion rather than motion of the environment. To generate different levels of vection and investigate its effects on time perception, we developed an abstract procedural tunnel generator. The generator can simulate different speeds and densities of tunnel sections (visibly distinguishable sections that form the virtual tunnel), as well as the degree of embodiment of the user avatar (with or without virtual hands). We exposed participants to various tunnel simulations with different durations, speeds, and densities in a remote desktop and a virtual reality (VR) laboratory study. Time passed subjectively faster under high-speed and high-density conditions in both studies. The experience of self-motion was also stronger under high-speed and high-density conditions. Both studies revealed a significant correlation between the perceived passage of time and perceived self-motion. Subjects in the virtual reality study reported a stronger self-motion experience, a faster perceived passage of time, and shorter time estimates than subjects in the desktop study. Our results suggest that a virtual tunnel simulation can manipulate time perception in virtual reality. We will explore these results for the development of virtual reality applications for therapeutic approaches in our future work. This could be particularly useful in treating disorders like depression, autism, and schizophrenia, which are known to be associated with distortions in time perception. For example, the tunnel could be therapeutically applied by resetting patients’ time perceptions by exposing them to the tunnel under different conditions, such as increasing or decreasing perceived time. KW - passage of time KW - illusion of self-motion KW - vection KW - virtual tunnel KW - therapeutic application KW - virtual reality KW - extended reality (XR) Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-301519 SN - 2673-4192 VL - 3 ER - TY - JOUR A1 - Steinhaeusser, Sophia C. A1 - Oberdörfer, Sebastian A1 - von Mammen, Sebastian A1 - Latoschik, Marc Erich A1 - Lugrin, Birgit T1 - Joyful adventures and frightening places – designing emotion-inducing virtual environments JF - Frontiers in Virtual Reality N2 - Virtual environments (VEs) can evoke and support emotions, as experienced when playing emotionally arousing games. We theoretically approach the design of fear and joy evoking VEs based on a literature review of empirical studies on virtual and real environments as well as video games’ reviews and content analyses. We define the design space and identify central design elements that evoke specific positive and negative emotions. Based on that, we derive and present guidelines for emotion-inducing VE design with respect to design themes, colors and textures, and lighting configurations. To validate our guidelines in two user studies, we 1) expose participants to 360° videos of VEs designed following the individual guidelines and 2) immerse them in a neutral, positive and negative emotion-inducing VEs combining all respective guidelines in Virtual Reality. The results support our theoretically derived guidelines by revealing significant differences in terms of fear and joy induction. KW - virtual reality KW - virtual environments KW - immersion KW - emotions KW - design Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-284831 SN - 2673-4192 VL - 3 ER - TY - JOUR A1 - Kempf, Sebastian A1 - Krug, Markus A1 - Puppe, Frank T1 - KIETA: Key-insight extraction from scientific tables JF - Applied Intelligence N2 - An important but very time consuming part of the research process is literature review. An already large and nevertheless growing ground set of publications as well as a steadily increasing publication rate continue to worsen the situation. Consequently, automating this task as far as possible is desirable. Experimental results of systems are key-insights of high importance during literature review and usually represented in form of tables. Our pipeline KIETA exploits these tables to contribute to the endeavor of automation by extracting them and their contained knowledge from scientific publications. The pipeline is split into multiple steps to guarantee modularity as well as analyzability, and agnosticim regarding the specific scientific domain up until the knowledge extraction step, which is based upon an ontology. Additionally, a dataset of corresponding articles has been manually annotated with information regarding table and knowledge extraction. Experiments show promising results that signal the possibility of an automated system, while also indicating limits of extracting knowledge from tables without any context. KW - table extraction KW - table understanding KW - ontology KW - key-insight extraction KW - information extraction Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-324180 SN - 0924-669X VL - 53 IS - 8 ER - TY - JOUR A1 - Fathy, Moustafa A1 - Darwish, Mostafa A. A1 - Abdelhamid, Al-Shaimaa M. A1 - Alrashedy, Gehad M. A1 - Othman, Othman Ali A1 - Naseem, Muhammad A1 - Dandekar, Thomas A1 - Othman, Eman M. T1 - Kinetin ameliorates cisplatin-induced hepatotoxicity and lymphotoxicity via attenuating oxidative damage, cell apoptosis and inflammation in rats JF - Biomedicines N2 - Though several previous studies reported the in vitro and in vivo antioxidant effect of kinetin (Kn), details on its action in cisplatin-induced toxicity are still scarce. In this study we evaluated, for the first time, the effects of kinetin in cisplatin (cp)- induced liver and lymphocyte toxicity in rats. Wistar male albino rats were divided into nine groups: (i) the control (C), (ii) groups 2,3 and 4, which received 0.25, 0.5 and 1 mg/kg kinetin for 10 days; (iii) the cisplatin (cp) group, which received a single intraperitoneal injection of CP (7.0 mg/kg); and (iv) groups 6, 7, 8 and 9, which received, for 10 days, 0.25, 0.5 and 1 mg/kg kinetin or 200 mg/kg vitamin C, respectively, and Cp on the fourth day. CP-injected rats showed a significant impairment in biochemical, oxidative stress and inflammatory parameters in hepatic tissue and lymphocytes. PCR showed a profound increase in caspase-3, and a significant decline in AKT gene expression. Intriguingly, Kn treatment restored the biochemical, redox status and inflammatory parameters. Hepatic AKT and caspase-3 expression as well as CD95 levels in lymphocytes were also restored. In conclusion, Kn mitigated oxidative imbalance, inflammation and apoptosis in CP-induced liver and lymphocyte toxicity; therefore, it can be considered as a promising therapy. KW - cisplatin KW - hepatotoxicity KW - lymphotoxicity KW - oxidative stress KW - AKT KW - CD95 KW - caspase-3 Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-281686 SN - 2227-9059 VL - 10 IS - 7 ER - TY - JOUR A1 - Oberdörfer, Sebastian A1 - Latoschik, Marc Erich T1 - Knowledge encoding in game mechanics: transfer-oriented knowledge learning in desktop-3D and VR JF - International Journal of Computer Games Technology N2 - Affine Transformations (ATs) are a complex and abstract learning content. Encoding the AT knowledge in Game Mechanics (GMs) achieves a repetitive knowledge application and audiovisual demonstration. Playing a serious game providing these GMs leads to motivating and effective knowledge learning. Using immersive Virtual Reality (VR) has the potential to even further increase the serious game’s learning outcome and learning quality. This paper compares the effectiveness and efficiency of desktop-3D and VR in respect to the achieved learning outcome. Also, the present study analyzes the effectiveness of an enhanced audiovisual knowledge encoding and the provision of a debriefing system. The results validate the effectiveness of the knowledge encoding in GMs to achieve knowledge learning. The study also indicates that VR is beneficial for the overall learning quality and that an enhanced audiovisual encoding has only a limited effect on the learning outcome. KW - games Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-201159 VL - 2019 ER - TY - THES A1 - Atzmüller, Martin T1 - Knowledge-Intensive Subgroup Mining - Techniques for Automatic and Interactive Discovery T1 - Wissensintensive Subgruppenentdeckung – Automatische und Interaktive Entdeckungsmethoden N2 - Data mining has proved its significance in various domains and applications. As an important subfield of the general data mining task, subgroup mining can be used, e.g., for marketing purposes in business domains, or for quality profiling and analysis in medical domains. The goal is to efficiently discover novel, potentially useful and ultimately interesting knowledge. However, in real-world situations these requirements often cannot be fulfilled, e.g., if the applied methods do not scale for large data sets, if too many results are presented to the user, or if many of the discovered patterns are already known to the user. This thesis proposes a combination of several techniques in order to cope with the sketched problems: We discuss automatic methods, including heuristic and exhaustive approaches, and especially present the novel SD-Map algorithm for exhaustive subgroup discovery that is fast and effective. For an interactive approach we describe techniques for subgroup introspection and analysis, and we present advanced visualization methods, e.g., the zoomtable that directly shows the most important parameters of a subgroup and that can be used for optimization and exploration. We also describe various visualizations for subgroup comparison and evaluation in order to support the user during these essential steps. Furthermore, we propose to include possibly available background knowledge that is easy to formalize into the mining process. We can utilize the knowledge in many ways: To focus the search process, to restrict the search space, and ultimately to increase the efficiency of the discovery method. We especially present background knowledge to be applied for filtering the elements of the problem domain, for constructing abstractions, for aggregating values of attributes, and for the post-processing of the discovered set of patterns. Finally, the techniques are combined into a knowledge-intensive process supporting both automatic and interactive methods for subgroup mining. The practical significance of the proposed approach strongly depends on the available tools. We introduce the VIKAMINE system as a highly-integrated environment for knowledge-intensive active subgroup mining. Also, we present an evaluation consisting of two parts: With respect to objective evaluation criteria, i.e., comparing the efficiency and the effectiveness of the subgroup discovery methods, we provide an experimental evaluation using generated data. For that task we present a novel data generator that allows a simple and intuitive specification of the data characteristics. The results of the experimental evaluation indicate that the novel SD-Map method outperforms the other described algorithms using data sets similar to the intended application concerning the efficiency, and also with respect to precision and recall for the heuristic methods. Subjective evaluation criteria include the user acceptance, the benefit of the approach, and the interestingness of the results. We present five case studies utilizing the presented techniques: The approach has been successfully implemented in medical and technical applications using real-world data sets. The method was very well accepted by the users that were able to discover novel, useful, and interesting knowledge. N2 - Data Mining wird mit großem Erfolg in vielen Domänen angewandt. Subgruppenentdeckung als wichtiges Teilgebiet des Data Mining kann zum Beispiel gut im Marketing, oder zur Qualitätskontrolle und Analyse in medizinischen Domänen eingesetzt werden. Das allgemeine Ziel besteht darin, potentiell nützliches and letztendlich interessantes Wissen zu entdecken. Jedoch können diese Anforderungen im praktischen Einsatz oft nicht erfüllt werden, etwa falls die eingesetzten Methoden eine schlechte Skalierbarkeit für größere Datensätze aufweisen, falls dem Benutzer zu viele Ergebnisse präsentiert werden, oder falls der Anwender viele der gefundenen Subgruppen-Muster schon kennt. Diese Arbeit stellt eine Kombination von automatischen und interaktiven Techniken vor, um mit den genannten Problemen besser umgehen zu können: Es werden automatische heuristische und vollständige Subgruppenentdeckungs-Verfahren diskutiert, und insbesondere der neuartige SD-Map Algorithmus zur vollständigen Subgruppenentdeckung vorgestellt der sowohl schnell als auch effektiv ist. Bezüglich der interaktiven Techniken werden Methoden zur Subgruppen-Introspektion und Analyse, und fortgeschrittene Visualisierungstechniken vorgestellt, beispielsweise die Zoomtable, die die für die Subgruppenentdeckung wichtigsten Parameter direkt visualisiert und zur Optimierung und Exploration eingesetzt werden kann. Zusätzlich werden verschiedene Visualisierungen zum Vergleich und zur Evaluation von Subgruppen beschrieben um den Benutzer bei diesen essentiellen Schritten zu unterstützen. Weiterhin wird leicht zu formalisierendes Hintergrundwissen vorgestellt, das im Subgruppenentdeckungsprozess in vielfältiger Weise eingesetzt werden kann: Um den Entdeckungsprozess zu fokussieren, den Suchraum einzuschränken, und letztendlich die Effizienz der Entdeckungsmethode zu erhöhen. Insbesondere wird Hintergrundwissen eingeführt, um die Elemente der Anwendungsdomäne zu filtern, um geeignete Abstraktionen zu definieren, Werte zusammenzufassen, und die gefundenen Subgruppenmuster nachzubearbeiten. Schließlich werden diese Techniken in einen wissensintensiven Prozess integriert, der sowohl automatische als auch interaktive Methoden zur Subgruppenentdeckung einschließt. Die praktische Bedeutung des vorgestellten Ansatzes hängt stark von den verfügbaren Werkzeugen ab. Dazu wird das VIKAMINE System als hochintegrierte Umgebung für die wissensintensive aktive Subgruppenentdeckung präsentiert. Die Evaluation des Ansatzes besteht aus zwei Teilen: Hinsichtlich einer Evaluation von Effizienz und Effektivität der Verfahren wird eine experimentelle Evaluation mit synthetischen Daten vorgestellt. Für diesen Zweck wird ein neuartiger in der Arbeit entwickelter Datengenerator angewandt, der eine einfache und intuitive Spezifikation der Datencharakteristiken erlaubt. Für die Evaluation des Ansatzes wurden Daten erzeugt, die ähnliche Charakteristiken aufweisen wie die Daten des angestrebten Einsatzbereichs. Die Ergebnisse der Evaluation zeigen, dass der neuartige SD-Map Algorithmus den anderen in der Arbeit beschriebenen Standard-Algorithmen überlegen ist. Sowohl hinsichtlich der Effizienz, als auch von Precision/Recall bezogen auf die heuristischen Algorithmen bietet SD-Map deutliche Vorteile. Subjektive Evaluationskriterien sind durch die Benutzerakzeptanz, den Nutzen des Ansatzes, und die Interessantheit der Ergebnisse gegeben. Es werden fünf Fallstudien für den Einsatz der vorgestellten Techniken beschrieben: Der Ansatz wurde in medizinischen und technischen Anwendungen mit realen Daten eingesetzt. Dabei wurde er von den Benutzern sehr gut angenommen, und im praktischen Einsatz konnte neuartiges, nützliches, und interessantes Wissen entdeckt werden. KW - Data Mining KW - Algorithmus KW - Visualisierung KW - Subgruppenentdeckung KW - Hintergrundwissen KW - Wissensendeckung KW - Data Mining KW - Visualisierung KW - Subgroup Mining KW - Background Knowledge KW - Knowledge Discovery KW - Data Mining KW - Visualization Y1 - 2006 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-21004 ER - TY - THES A1 - Somody, Joseph Christian Campbell T1 - Leveraging deep learning for identification and structural determination of novel protein complexes from \(in\) \(situ\) electron cryotomography of \(Mycoplasma\) \(pneumoniae\) T1 - Tiefenlernen als Werkzeug zur Identifizierung und Strukturbestimmung neuer Proteinkomplexe aus der \(in\)-\(situ\)-Elektronenkryotomographie von \(Mycoplasma\) \(pneumoniae\) N2 - The holy grail of structural biology is to study a protein in situ, and this goal has been fast approaching since the resolution revolution and the achievement of atomic resolution. A cell's interior is not a dilute environment, and proteins have evolved to fold and function as needed in that environment; as such, an investigation of a cellular component should ideally include the full complexity of the cellular environment. Imaging whole cells in three dimensions using electron cryotomography is the best method to accomplish this goal, but it comes with a limitation on sample thickness and produces noisy data unamenable to direct analysis. This thesis establishes a novel workflow to systematically analyse whole-cell electron cryotomography data in three dimensions and to find and identify instances of protein complexes in the data to set up a determination of their structure and identity for success. Mycoplasma pneumoniae is a very small parasitic bacterium with fewer than 700 protein-coding genes, is thin enough and small enough to be imaged in large quantities by electron cryotomography, and can grow directly on the grids used for imaging, making it ideal for exploratory studies in structural proteomics. As part of the workflow, a methodology for training deep-learning-based particle-picking models is established. As a proof of principle, a dataset of whole-cell Mycoplasma pneumoniae tomograms is used with this workflow to characterize a novel membrane-associated complex observed in the data. Ultimately, 25431 such particles are picked from 353 tomograms and refined to a density map with a resolution of 11 Å. Making good use of orthogonal datasets to filter search space and verify results, structures were predicted for candidate proteins and checked for suitable fit in the density map. In the end, with this approach, nine proteins were found to be part of the complex, which appears to be associated with chaperone activity and interact with translocon machinery. Visual proteomics refers to the ultimate potential of in situ electron cryotomography: the comprehensive interpretation of tomograms. The workflow presented here is demonstrated to help in reaching that potential. N2 - Der heilige Gral der Strukturbiologie ist die Untersuchung eines Proteins in situ, und dieses Ziel ist seit der Auflösungsrevolution und dem Erreichen der atomaren Auflösung in greifbare Nähe gerückt. Das Innere einer Zelle ist keine verdünnte Umgebung, und Proteine haben sich so entwickelt, dass sie sich falten und so funktionieren, wie es in dieser Umgebung erforderlich ist; daher sollte die Untersuchung einer zellulären Komponente idealerweise die gesamte Komplexität der zellulären Umgebung umfassen. Die Abbildung ganzer Zellen in drei Dimensionen mit Hilfe der Elektronenkryotomographie ist die beste Methode, um dieses Ziel zu erreichen, aber sie ist mit einer Beschränkung der Probendicke verbunden und erzeugt verrauschte Daten, die sich nicht für eine direkte Analyse eignen. In dieser Dissertation wird ein neuartiger Workflow zur systematischen dreidimensionalen Analyse von Ganzzell-Elektronenkryotomographiedaten und zur Auffindung und Identifizierung von Proteinkomplexen in diesen Daten entwickelt, um eine erfolgreiche Bestimmung ihrer Struktur und Identität zu ermöglichen. Mycoplasma pneumoniae ist ein sehr kleines parasitäres Bakterium mit weniger als 700 proteinkodierenden Genen. Es ist dünn und klein genug, um in grossen Mengen durch Elektronenkryotomographie abgebildet zu werden, und kann direkt auf den für die Abbildung verwendeten Gittern wachsen, was es ideal für Sondierungsstudien in der strukturellen Proteomik macht. Als Teil des Workflows wird eine Methodik für das Training von Deep-Learning-basierten Partikelpicken-Modellen entwickelt. Als Proof-of-Principle wird ein Dataset von Ganzzell-Tomogrammen von Mycoplasma pneumoniae mit diesem Workflow verwendet, um einen neuartigen membranassoziierten Komplex zu charakterisieren, der in den Daten beobachtet wurde. Insgesamt wurden 25431 solcher Partikel aus 353 Tomogrammen gepickt und zu einer Dichtekarte mit einer Auflösung von 11 Å verfeinert. Unter Verwendung orthogonaler Datensätze zur Filterung des Suchraums und zur Überprüfung der Ergebnisse wurden Strukturen für Protein-Kandidaten vorhergesagt und auf ihre Eignung für die Dichtekarte überprüft. Letztendlich wurden mit diesem Ansatz neun Proteine als Bestandteile des Komplexes gefunden, der offenbar mit der Chaperonaktivität in Verbindung steht und mit der Translocon-Maschinerie interagiert. Das ultimative Potenzial der In-situ-Elektronenkryotomographie – die umfassende Interpretation von Tomogrammen – wird als visuelle Proteomik bezeichnet. Der hier vorgestellte Workflow soll dabei helfen, dieses Potenzial auszuschöpfen. KW - Kryoelektronenmikroskopie KW - Tomografie KW - Mycoplasma pneumoniae KW - Deep learning KW - cryo-EM KW - cryo-ET KW - tomography KW - mycoplasma KW - pneumoniae KW - deep learning KW - particle picking KW - membrane protein KW - visual proteomics Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-313447 ER - TY - JOUR A1 - Fischer, Norbert A1 - Hartelt, Alexander A1 - Puppe, Frank T1 - Line-level layout recognition of historical documents with background knowledge JF - Algorithms N2 - Digitization and transcription of historic documents offer new research opportunities for humanists and are the topics of many edition projects. However, manual work is still required for the main phases of layout recognition and the subsequent optical character recognition (OCR) of early printed documents. This paper describes and evaluates how deep learning approaches recognize text lines and can be extended to layout recognition using background knowledge. The evaluation was performed on five corpora of early prints from the 15th and 16th Centuries, representing a variety of layout features. While the main text with standard layouts could be recognized in the correct reading order with a precision and recall of up to 99.9%, also complex layouts were recognized at a rate as high as 90% by using background knowledge, the full potential of which was revealed if many pages of the same source were transcribed. KW - layout recognition KW - background knowledge KW - historical document analysis KW - fully convolutional neural networks KW - baseline detection KW - text line detection Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-310938 SN - 1999-4893 VL - 16 IS - 3 ER - TY - JOUR A1 - Klemz, Boris A1 - Rote, Günter T1 - Linear-Time Algorithms for Maximum-Weight Induced Matchings and Minimum Chain Covers in Convex Bipartite Graphs JF - Algorithmica N2 - A bipartite graph G=(U,V,E) is convex if the vertices in V can be linearly ordered such that for each vertex u∈U, the neighbors of u are consecutive in the ordering of V. An induced matching H of G is a matching for which no edge of E connects endpoints of two different edges of H. We show that in a convex bipartite graph with n vertices and m weighted edges, an induced matching of maximum total weight can be computed in O(n+m) time. An unweighted convex bipartite graph has a representation of size O(n) that records for each vertex u∈U the first and last neighbor in the ordering of V. Given such a compact representation, we compute an induced matching of maximum cardinality in O(n) time. In convex bipartite graphs, maximum-cardinality induced matchings are dual to minimum chain covers. A chain cover is a covering of the edge set by chain subgraphs, that is, subgraphs that do not contain induced matchings of more than one edge. Given a compact representation, we compute a representation of a minimum chain cover in O(n) time. If no compact representation is given, the cover can be computed in O(n+m) time. All of our algorithms achieve optimal linear running time for the respective problem and model, and they improve and generalize the previous results in several ways: The best algorithms for the unweighted problem versions had a running time of O(n\(^{2}\)) (Brandstädt et al. in Theor. Comput. Sci. 381(1–3):260–265, 2007. https://doi.org/10.1016/j.tcs.2007.04.006). The weighted case has not been considered before. KW - dynamic programming KW - graph algorithm KW - induced matching KW - chain cover KW - convex bipartite graph KW - certifying algorithm Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-267876 SN - 1432-0541 VL - 84 IS - 4 ER - TY - JOUR A1 - Wienrich, Carolin A1 - Carolus, Astrid A1 - Markus, André A1 - Augustin, Yannik A1 - Pfister, Jan A1 - Hotho, Andreas T1 - Long-term effects of perceived friendship with intelligent voice assistants on usage behavior, user experience, and social perceptions JF - Computers N2 - Social patterns and roles can develop when users talk to intelligent voice assistants (IVAs) daily. The current study investigates whether users assign different roles to devices and how this affects their usage behavior, user experience, and social perceptions. Since social roles take time to establish, we equipped 106 participants with Alexa or Google assistants and some smart home devices and observed their interactions for nine months. We analyzed diverse subjective (questionnaire) and objective data (interaction data). By combining social science and data science analyses, we identified two distinct clusters—users who assigned a friendship role to IVAs over time and users who did not. Interestingly, these clusters exhibited significant differences in their usage behavior, user experience, and social perceptions of the devices. For example, participants who assigned a role to IVAs attributed more friendship to them used them more frequently, reported more enjoyment during interactions, and perceived more empathy for IVAs. In addition, these users had distinct personal requirements, for example, they reported more loneliness. This study provides valuable insights into the role-specific effects and consequences of voice assistants. Recent developments in conversational language models such as ChatGPT suggest that the findings of this study could make an important contribution to the design of dialogic human–AI interactions. KW - intelligent voice assistant KW - smart speaker KW - social relationship KW - social role KW - long-term analysis KW - social interaction KW - human–computer interaction KW - anthropomorphism Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-313552 SN - 2073-431X VL - 12 IS - 4 ER - TY - RPRT A1 - Loh, Frank A1 - Geißler, Stefan A1 - Hoßfeld, Tobias T1 - LoRaWAN Network Planning in Smart Environments: Towards Reliability, Scalability, and Cost Reduction T2 - Würzburg Workshop on Next-Generation Communication Networks (WueWoWas'22) N2 - The goal in this work is to present a guidance for LoRaWAN planning to improve overall reliability for message transmissions and scalability. At the end, the cost component is discussed. Therefore, a five step approach is presented that helps to plan a LoRaWAN deployment step by step: Based on the device locations, an initial gateway placement is suggested followed by in-depth frequency and channel access planning. After an initial planning phase, updates for channel access and the initial gateway planning is suggested that should also be done periodically during network operation. Since current gateway placement approaches are only studied with random channel access, there is a lot of potential in the cell planning phase. Furthermore, the performance of different channel access approaches is highly related on network load, and thus cell size and sensor density. Last, the influence of different cell planning ideas on expected costs are discussed. KW - Datennetz KW - LoRaWan Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-280829 ER - TY - THES A1 - Krenzer, Adrian T1 - Machine learning to support physicians in endoscopic examinations with a focus on automatic polyp detection in images and videos T1 - Maschinelles Lernen zur Unterstützung von Ärzten bei endoskopischen Untersuchungen mit Schwerpunkt auf der automatisierten Polypenerkennung in Bildern und Videos N2 - Deep learning enables enormous progress in many computer vision-related tasks. Artificial Intel- ligence (AI) steadily yields new state-of-the-art results in the field of detection and classification. Thereby AI performance equals or exceeds human performance. Those achievements impacted many domains, including medical applications. One particular field of medical applications is gastroenterology. In gastroenterology, machine learning algorithms are used to assist examiners during interventions. One of the most critical concerns for gastroenterologists is the development of Colorectal Cancer (CRC), which is one of the leading causes of cancer-related deaths worldwide. Detecting polyps in screening colonoscopies is the essential procedure to prevent CRC. Thereby, the gastroenterologist uses an endoscope to screen the whole colon to find polyps during a colonoscopy. Polyps are mucosal growths that can vary in severity. This thesis supports gastroenterologists in their examinations with automated detection and clas- sification systems for polyps. The main contribution is a real-time polyp detection system. This system is ready to be installed in any gastroenterology practice worldwide using open-source soft- ware. The system achieves state-of-the-art detection results and is currently evaluated in a clinical trial in four different centers in Germany. The thesis presents two additional key contributions: One is a polyp detection system with ex- tended vision tested in an animal trial. Polyps often hide behind folds or in uninvestigated areas. Therefore, the polyp detection system with extended vision uses an endoscope assisted by two additional cameras to see behind those folds. If a polyp is detected, the endoscopist receives a vi- sual signal. While the detection system handles the additional two camera inputs, the endoscopist focuses on the main camera as usual. The second one are two polyp classification models, one for the classification based on shape (Paris) and the other on surface and texture (NBI International Colorectal Endoscopic (NICE) classification). Both classifications help the endoscopist with the treatment of and the decisions about the detected polyp. The key algorithms of the thesis achieve state-of-the-art performance. Outstandingly, the polyp detection system tested on a highly demanding video data set shows an F1 score of 90.25 % while working in real-time. The results exceed all real-time systems in the literature. Furthermore, the first preliminary results of the clinical trial of the polyp detection system suggest a high Adenoma Detection Rate (ADR). In the preliminary study, all polyps were detected by the polyp detection system, and the system achieved a high usability score of 96.3 (max 100). The Paris classification model achieved an F1 score of 89.35 % which is state-of-the-art. The NICE classification model achieved an F1 score of 81.13 %. Furthermore, a large data set for polyp detection and classification was created during this thesis. Therefore a fast and robust annotation system called Fast Colonoscopy Annotation Tool (FastCAT) was developed. The system simplifies the annotation process for gastroenterologists. Thereby the i gastroenterologists only annotate key parts of the endoscopic video. Afterward, those video parts are pre-labeled by a polyp detection AI to speed up the process. After the AI has pre-labeled the frames, non-experts correct and finish the annotation. This annotation process is fast and ensures high quality. FastCAT reduces the overall workload of the gastroenterologist on average by a factor of 20 compared to an open-source state-of-art annotation tool. N2 - Deep Learning ermöglicht enorme Fortschritte bei vielen Aufgaben im Bereich der Computer Vision. Künstliche Intelligenz (KI) liefert ständig neue Spitzenergebnisse im Bereich der Erkennung und Klassifizierung. Dabei erreicht oder übertrifft die Leistung von KI teilweise die menschliche Leistung. Diese Errungenschaften wirken sich auf viele Bereiche aus, darunter auch auf medizinische Anwendungen. Ein besonderer Bereich der medizinischen Anwendungen ist die Gastroenterologie. In der Gastroenterologie werden Algorithmen des maschinellen Lernens eingesetzt, um den Untersucher bei medizinischen Eingriffen zu unterstützen. Eines der größten Probleme für Gastroenterologen ist die Entwicklung von Darmkrebs, die weltweit eine der häufigsten krebsbedingten Todesursachen ist. Die Erkennung von Polypen bei Darmspiegelungen ist das wichtigste Verfahren zur Vorbeugung von Darmkrebs. Dabei untersucht der Gastroenterologe den Dickdarm im Rahmen einer Koloskopie, um z.B. Polypen zu finden. Polypen sind Schleimhautwucherungen, die unterschiedlich stark ausgeprägt sein können. Diese Arbeit unterstützt Gastroenterologen bei ihren Untersuchungen mit automatischen Erkennungssystemen und Klassifizierungssystemen für Polypen. Der Hauptbeitrag ist ein Echtzeitpolypenerkennungssystem. Dieses System kann in jeder gastroenterologischen Praxis weltweit mit Open- Source-Software installiert werden. Das System erzielt Erkennungsergebnisse auf dem neusten Stand der Technik und wird derzeit in einer klinischen Studie in vier verschiedenen Praxen in Deutschland evaluiert. In dieser Arbeit werden zwei weitere wichtige Beiträge vorgestellt: Zum einen ein Polypenerkennungssystem mit erweiterter Sicht, das in einem Tierversuch getestet wurde. Polypen verstecken sich oft hinter Falten oder in nicht untersuchten Bereichen. Daher verwendet das Polypenerkennungssystem mit erweiterter Sicht ein Endoskop, das von zwei zusätzlichen Kameras unterstützt wird, um hinter diese Falten zu sehen. Wenn ein Polyp entdeckt wird, erhält der Endoskopiker ein visuelles Signal. Während das Erkennungssystem die beiden zusätzlichen Kameraeingaben verarbeitet, konzentriert sich der Endoskopiker wie gewohnt auf die Hauptkamera. Das zweite sind zwei Polypenklassifizierungsmodelle, eines für die Klassifizierung anhand der Form (Paris) und das andere anhand der Oberfläche und Textur (NICE-Klassifizierung). Beide Klassifizierungen helfen dem Endoskopiker bei der Behandlung und Entscheidung über den erkannten Polypen. Die Schlüsselalgorithmen der Dissertation erreichen eine Leistung, die dem neuesten Stand der Technik entspricht. Herausragend ist, dass das auf einem anspruchsvollen Videodatensatz getestete Polypenerkennungssystem einen F1-Wert von 90,25 % aufweist, während es in Echtzeit arbeitet. Die Ergebnisse übertreffen alle Echtzeitsysteme für Polypenerkennung in der Literatur. Darüber hinaus deuten die ersten vorläufigen Ergebnisse einer klinischen Studie des Polypenerkennungssystems auf eine hohe Adenomdetektionsrate ADR hin. In dieser Studie wurden alle Polypen durch das Polypenerkennungssystem erkannt, und das System erreichte einen hohe Nutzerfreundlichkeit von 96,3 (maximal 100). Bei der automatischen Klassifikation von Polypen basierend auf der Paris Klassifikations erreichte das in dieser Arbeit entwickelte System einen F1-Wert von 89,35 %, was dem neuesten Stand der Technik entspricht. Das NICE-Klassifikationsmodell erreichte eine F1- Wert von 81,13 %. Darüber hinaus wurde im Rahmen dieser Arbeit ein großer Datensatz zur Polypenerkennung und -klassifizierung erstellt. Dafür wurde ein schnelles und robustes Annotationssystem namens FastCAT entwickelt. Das System vereinfacht den Annotationsprozess für Gastroenterologen. Die Gastroenterologen annotieren dabei nur die wichtigsten Teile des endoskopischen Videos. Anschließend werden diese Videoteile von einer Polypenerkennungs-KI vorverarbeitet, um den Prozess zu beschleunigen. Nachdem die KI die Bilder vorbeschriftet hat, korrigieren und vervollständigen Nicht-Experten die Annotationen. Dieser Annotationsprozess ist schnell und gewährleistet eine hohe Qualität. FastCAT reduziert die Gesamtarbeitsbelastung des Gastroenterologen im Durchschnitt um den Faktor 20 im Vergleich zu einem Open-Source-Annotationstool auf dem neuesten Stand der Technik. KW - Deep Learning KW - Maschinelles Lernen KW - Maschinelles Sehen KW - Machine Learning KW - Object Detection KW - Medical Image Analysis KW - Computer Vision KW - Gastroenterologische Endoskopie KW - Polypektomie Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-319119 ER - TY - RPRT A1 - Riegler, Clemens A1 - Werner, Lennart A1 - Kayal, Hakan T1 - MAPLE: Marsian Autorotation Probe Lander Experiment N2 - The first step towards aerial planetary exploration has been made. Ingenuity shows extremely promising results, and new missions are already underway. Rotorcraft are capable of flight. This capability could be utilized to support the last stages of Entry, Descent, and Landing. Thus, mass and complexity could be scaled down. Autorotation is one method of descent. It describes unpowered descent and landing, typically performed by helicopters in case of an engine failure. MAPLE is suggested to test these procedures and understand autorotation on other planets. In this series of experiments, the Ingenuity helicopter is utilized. Ingenuity would autorotate a ”mid-air-landing” before continuing with normal flight. Ultimately, the collected data shall help to understand autorotation on Mars and its utilization for interplanetary exploration. T3 - Raumfahrttechnik und Extraterrestrik - 2 KW - autorotation KW - descent KW - Mars KW - rotorcraft KW - landing KW - aerospace Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-282390 ER -