TY  - JOUR
A1  - Steinhaeusser, Sophia C.
A1  - Oberdörfer, Sebastian
A1  - von Mammen, Sebastian
A1  - Latoschik, Marc Erich
A1  - Lugrin, Birgit
T1  - Joyful adventures and frightening places – designing emotion-inducing virtual environments
JF  - Frontiers in Virtual Reality
N2  - Virtual environments (VEs) can evoke and support emotions, as experienced when playing emotionally arousing games. We theoretically approach the design of fear and joy evoking VEs based on a literature review of empirical studies on virtual and real environments as well as video games’ reviews and content analyses. We define the design space and identify central design elements that evoke specific positive and negative emotions. Based on that, we derive and present guidelines for emotion-inducing VE design with respect to design themes, colors and textures, and lighting configurations. To validate our guidelines in two user studies, we 1) expose participants to 360° videos of VEs designed following the individual guidelines and 2) immerse them in a neutral, positive and negative emotion-inducing VEs combining all respective guidelines in Virtual Reality. The results support our theoretically derived guidelines by revealing significant differences in terms of fear and joy induction.
KW  - virtual reality
KW  - virtual environments
KW  - immersion
KW  - emotions
KW  - design
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-284831
SN  - 2673-4192
VL  - 3
ER  - 
TY  - JOUR
A1  - Scherer, Marc
A1  - Fleishman, Sarel J.
A1  - Jones, Patrik R.
A1  - Dandekar, Thomas
A1  - Bencurova, Elena
T1  - Computational Enzyme Engineering Pipelines for Optimized Production of Renewable Chemicals
JF  - Frontiers in Bioengineering and Biotechnology
N2  - To enable a sustainable supply of chemicals, novel biotechnological solutions are required that replace the reliance on fossil resources. One potential solution is to utilize tailored biosynthetic modules for the metabolic conversion of CO2 or organic waste to chemicals and fuel by microorganisms. Currently, it is challenging to commercialize biotechnological processes for renewable chemical biomanufacturing because of a lack of highly active and specific biocatalysts. As experimental methods to engineer biocatalysts are time- and cost-intensive, it is important to establish efficient and reliable computational tools that can speed up the identification or optimization of selective, highly active, and stable enzyme variants for utilization in the biotechnological industry. Here, we review and suggest combinations of effective state-of-the-art software and online tools available for computational enzyme engineering pipelines to optimize metabolic pathways for the biosynthesis of renewable chemicals. Using examples relevant for biotechnology, we explain the underlying principles of enzyme engineering and design and illuminate future directions for automated optimization of biocatalysts for the assembly of synthetic metabolic pathways.
KW  - computational
KW  - enzyme
KW  - engineering
KW  - design
KW  - biomanufacturing
KW  - biofuel
KW  - microbes
KW  - metabolism
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-240598
SN  - 2296-4185
VL  - 9
ER  -