TY  - JOUR
A1  - Isaias, Ioannis U.
A1  - Brumberg, Joachim
A1  - Pozzi, Nicoló G.
A1  - Palmisano, Chiara
A1  - Canessa, Andrea
A1  - Marotta, Giogio
A1  - Volkmann, Jens
A1  - Pezzoli, Gianni
T1  - Brain metabolic alterations herald falls in patients with Parkinson's disease
JF  - Annals of Clinical and Translational Neurology
N2  - Pathophysiological understanding of gait and balance disorders in Parkinson’s disease is insufficient and late recognition of fall risk limits efficacious followup to prevent or delay falls. We show a distinctive reduction of glucose metabolism in the left posterior parietal cortex, with increased metabolic activity in the cerebellum, in parkinsonian patients 6–8 months before their first fall episode. Falls in Parkinson’s disease may arise from altered cortical processing of body spatial orientation, possibly predicted by abnormal cortical metabolism.
KW  - Parkionson's disease
KW  - brain metabolic alterations
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-235982
VL  - 7
IS  - 4
ER  -