TY  - JOUR
A1  - Hofstetter, Julia
A1  - Ogunleye, Ayoola
A1  - Kutschke, André
A1  - Buchholz, Lisa Marie
A1  - Wolf, Elmar
A1  - Raabe, Thomas
A1  - Gallant, Peter
T1  - Spt5 interacts genetically with Myc and is limiting for brain tumor growth in Drosophila
JF  - Life Science Alliance
N2  - The transcription factor SPT5 physically interacts with MYC oncoproteins and is essential for efficient transcriptional activation of MYC targets in cultured cells. Here, we use Drosophila to address the relevance of this interaction in a living organism. Spt5 displays moderate synergy with Myc in fast proliferating young imaginal disc cells. During later development, Spt5-knockdown has no detectable consequences on its own, but strongly enhances eye defects caused by Myc overexpression. Similarly, Spt5-knockdown in larval type 2 neuroblasts has only mild effects on brain development and survival of control flies, but dramatically shrinks the volumes of experimentally induced neuroblast tumors and significantly extends the lifespan of tumor-bearing animals. This beneficial effect is still observed when Spt5 is knocked down systemically and after tumor initiation, highlighting SPT5 as a potential drug target in human oncology.
KW  - Drosophila
KW  - transcription factor SPT5
KW  - Myc
KW  - brain tumor
KW  - tumor growth
Y1  - 2024
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-350197
SN  - 2575-1077
VL  - 7
IS  - 1
ER  -