TY  - JOUR
A1  - Baur, Johannes
A1  - Ritter, Christian O.
A1  - Germer, Christoph-Thomas
A1  - Klein, Ingo
A1  - Kickuth, Ralph
A1  - Steger, Ulrich
T1  - Transarterial chemoembolization with drug-eluting beads versus conventional transarterial chemoembolization in locally advanced hepatocellular carcinoma
JF  - Hepatic Medicine
N2  - Purpose: In hepatocellular carcinoma patients with large or multinodal tumors, where curative treatment options are not feasible, transarterial therapies play a major role. Transarterial chemoembolization (TACE) with drug-eluting beads (DEB-TACE) is a promising new approach due to higher intratumoral and lower systemic concentration of the chemotherapeutic agent compared to conventional TACE (cTACE).

Patients and methods: In a retrospective analysis, 32 patients with hepatocellular carcinoma who received either DEB or a cTACE were compared regarding survival time, disease recurrence, and side effects such as pain and fever.
Results: No significant differences could be detected between the cTACE and DEB-TACE groups with regard to mean hospital stay, appearance of postinterventional fever, or 30-day mortality. However, the application of intravenous analgesics as postinterventional pain medication was needed more often in patients treated with DEB-TACE (57.1% vs 12.5%, P=0.0281). The overall median survival after the initial procedure was 10.8 months in the cTACE group and 9.2 months in the DEB-TACE group, showing no significant difference.

Conclusion: No survival benefit for patients treated with either DEB-TACE or cTACE was observed. Surprisingly, a higher rate of postinterventional pain could be detected after DEB-TACE.
KW  - transarterial chemoembolization
KW  - hepatocellular carcinoma
KW  - drug-eluting beads
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-146553
VL  - 2016
IS  - 8
ER  - 
TY  - JOUR
A1  - Baur, Johannes
A1  - Schedelbeck, Ulla
A1  - Pulzer, Alina
A1  - Bluemel, Christina
A1  - Wild, Vanessa
A1  - Fassnacht, Martin
A1  - Steger, U.
T1  - A case report of a solitary pancreatic metastasis of an adrenocortical carcinoma
JF  - BMC Surgery
N2  - Background
Solitary metastases to the pancreas are rare. Therefore the value of resection in curative intention remains unclear. In the literature there are several promising reports about resection of solitary metastasis to the pancreas mainly of renal origin.

Case presentation
Here we report for the first time on the surgical therapy of a 1.5 cm solitary pancreatic metastasis of an adrenocortical carcinoma. The metastasis occurred almost 6 years after resection of the primary tumor. A partial pancreatoduodenectomy was performed and postoperatively adjuvant mitotane treatment was initiated. During the follow-up of 3 years after surgery no evidence of tumor recurrence occurred.

Conclusion
Resection of pancreatic tumors should be considered, even if the mass is suspicious for metastatic disease including recurrence of adrenocortical cancer.
KW  - surgical treatment
KW  - adrenocortical
KW  - carcinoma metastases to pancreas
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-126130
VL  - 15
IS  - 93
ER  -