Sila-Pharmaka, 31. Mitt. [1] Synthese, Struktur und pharmakologische Eigenschaften von Diphenyl(2-piperidinoethoxymethyl)silanol und seinem Kohlenstoff-Analogon
Sila-Pharmaca, 31 th Communication [1] Synthesis, Structure, and Pharmacological Properties of Diphenyl(2-piperidinoethoxymethyl)silanol and its Carbon Analogue
Please always quote using this URN: urn:nbn:de:bvb:20-opus-128410
- In the course of systematic investigations on sila-substituted parasympatholytics the diphenyl(2-aminoethoxymethyl)silanols 3b and 4b (and its carbon analogue 4a) were synthesized and characterized by their physical and chemical properties. In the solid state 4a and 4b form strong O-H---N hydrogen bonds, which are intramolecular (4a) and intermolecular (4b), respectively. 4a and 4b were found to be weak antimuscarinic agents (4b >4a) and strong papaverine-like spasmolytics (4a ≈4b).
| Author: | Reinhold Tacke, Hartwig Lange, William S. Sheldrick, Günter Lambrecht, Ulrich Moser, Ernst Mutschler |
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| URN: | urn:nbn:de:bvb:20-opus-128410 |
| Document Type: | Journal article |
| Faculties: | Fakultät für Chemie und Pharmazie / Institut für Anorganische Chemie |
| Language: | German |
| Parent Title (German): | Zeitschrift für Naturforschung B |
| Year of Completion: | 1983 |
| Volume: | 38 |
| Issue: | 6 |
| Pagenumber: | 738-746 |
| Source: | Zeitschrift für Naturforschung B. Band 38, Heft 6, Seiten 738–746 |
| Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 546 Anorganische Chemie |
| Tag: | antimuscarinic and papaverine-like activity; crystal and molecular structure; sila-substitution |
| Release Date: | 2016/03/01 |
| Licence (German): |  Deutsches Urheberrecht |