A role for locus coeruleus in Parkinson tremor

Please always quote using this URN: urn:nbn:de:bvb:20-opus-133955
  • We analyzed rest tremor, one of the etiologically most elusive hallmarks of Parkinson disease(PD), in 12 consecutive PD patients during a specific task activating the locus coeruleus (LC) to investigate a putative role of noradrenaline (NA) in tremor generation and suppression. Clinical diagnosis was confirmed in all subjects by reduced dopamine reuptake transporter (DAT) binding values investigated by single photon computed tomography imaging (SPECT) with [\(^{123}\)I] N-\(\omega\)-fluoropropyl-2 \(\beta\)-carbomethoxy-3We analyzed rest tremor, one of the etiologically most elusive hallmarks of Parkinson disease(PD), in 12 consecutive PD patients during a specific task activating the locus coeruleus (LC) to investigate a putative role of noradrenaline (NA) in tremor generation and suppression. Clinical diagnosis was confirmed in all subjects by reduced dopamine reuptake transporter (DAT) binding values investigated by single photon computed tomography imaging (SPECT) with [\(^{123}\)I] N-\(\omega\)-fluoropropyl-2 \(\beta\)-carbomethoxy-3 \(\beta\)-(4-iodophenyl) tropane (FP-CIT). The intensity of tremor (i.e., the power of Electromyography [EMG] signals), but not its frequency, significantly increased during the task. In six subjects, tremor appeared selectively during the task. In a second part of the study, we retrospectively reviewed SPECT with FP-CIT data and confirmed the lack of correlation between dopaminergic loss and tremor by comparing DAT binding values of 82 PD subjects with bilateral tremor (n = 27), unilateral tremor (n = 22), and no tremor (n = 33). This study suggests a role of the LC in Parkinson tremor.show moreshow less

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Metadaten
Author: Ioannis U. Isaias, Alberto Marzegan, Gianni Pezzoli, Giorgio Marotta, Margherita Canesi, Gabriele E. M. Biella, Jens Volkmann, Paolo Cavallari
URN:urn:nbn:de:bvb:20-opus-133955
Document Type:Journal article
Faculties:Medizinische Fakultät / Neurologische Klinik und Poliklinik
Language:English
Parent Title (English):Frontiers in Human Neuroscience
Year of Completion:2012
Volume:5
Issue:179
Source:Frontiers in Human Neuroscience 5:179. doi: 10.3389/fnhum.2011.00179
DOI:https://doi.org/10.3389/fnhum.2011.00179
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 616 Krankheiten
Tag:basal ganglia; binding; disease; dopamine; functional neuroanatomy; locus coeruleus; noradrenalin; norepinephrine; parkinson disease; progression; rat; resting tremor; tremor
Release Date:2017/02/21
Licence (German):License LogoCC BY-NC: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell