Modeling infectious diseases and host-microbe interactions in gastrointestinal organoids

Please always quote using this URN: urn:nbn:de:bvb:20-opus-138788
  • Advances in stem cell research have allowed the development of 3-dimensional (3D) primary cell cultures termed organoid cultures, as they closely mimic the in vivo organization of different cell lineages. Bridging the gap between 2-dimensional (2D) monotypic cancer cell lines and whole organisms, organoids are now widely applied to model development and disease. Organoids hold immense promise for addressing novel questions in host-microbe interactions, infectious diseases and the resulting inflammatory conditions. Researchers have started toAdvances in stem cell research have allowed the development of 3-dimensional (3D) primary cell cultures termed organoid cultures, as they closely mimic the in vivo organization of different cell lineages. Bridging the gap between 2-dimensional (2D) monotypic cancer cell lines and whole organisms, organoids are now widely applied to model development and disease. Organoids hold immense promise for addressing novel questions in host-microbe interactions, infectious diseases and the resulting inflammatory conditions. Researchers have started to use organoids for modeling infection with pathogens, such as Helicobacter pylori or Salmonella enteritica, gut- microbiota interactions and inflammatory bowel disease. Future studies will broaden the spectrum of microbes used and continue to establish organoids as a standard model for human host-microbial interactions. Moreover, they will increasingly exploit the unique advantages of organoids, for example to address patient-specific responses to microbes.show moreshow less
Metadaten
Author: Sina Bartfeld
URN:urn:nbn:de:bvb:20-opus-138788
Document Type:Preprint
Faculties:Medizinische Fakultät / Institut für Molekulare Infektionsbiologie
Language:English
Parent Title (English):Developmental Biology
ISSN:0012-1606
Year of Completion:2016
Source:Developmental Biology, http://dx.doi.org/10.1016/j.ydbio.2016.09.014
URL:http://www.sciencedirect.com/science/article/pii/S0012160616304602
DOI:https://doi.org/http://dx.doi.org/10.1016/j.ydbio.2016.09.014
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=27640087
Sonstige beteiligte Institutionen:Zentrum für Infektionsforschung (ZINF): Nachwuchsgruppe 2
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:gastrointestinal disease; helicobacter; inflammatory bowel disease; microbiota; norovirus; organoid culture; rotavirus; salmonella
Release Date:2017/09/28
Note:
This is the accepted version of the following article: Bartfeld, Sina, Modeling infectious diseases and host-microbe interactions in gastrointestinal organoids, Developmental Biology, 2016, 420, 2, 262-270. http://dx.doi.org/10.1016/j.ydbio.2016.09.014
Licence (German):License LogoCC BY-NC-ND: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell, Keine Bearbeitung