Opposing alterations in anxiety and species-typical behaviours in serotonin transporter overexpressor and knockout mice

Please always quote using this URN: urn:nbn:de:bvb:20-opus-141222
  • Human gene association studies have produced conflicting findings regarding the relationship between the 5-HT transporter (5-HTT) and anxiety. In the present study genetically modified mice were utilised to examine the effects of changes in 5-HTT expression on anxiety. In addition, the influence of 5-HTT expression on two innate “species-typical” behaviours (burrowing and marble burying) and body weight was explored. Across a range of models, 5-HTT overexpressing mice displayed reduced anxiety-like behaviour whilst 5-HTT knockout miceHuman gene association studies have produced conflicting findings regarding the relationship between the 5-HT transporter (5-HTT) and anxiety. In the present study genetically modified mice were utilised to examine the effects of changes in 5-HTT expression on anxiety. In addition, the influence of 5-HTT expression on two innate “species-typical” behaviours (burrowing and marble burying) and body weight was explored. Across a range of models, 5-HTT overexpressing mice displayed reduced anxiety-like behaviour whilst 5-HTT knockout mice showed increased anxiety-like behaviour, compared to wildtype controls. In tests of species-typical behaviour 5-HTT overexpressing mice showed some facilitation whilst 5-HTT knockout mice were impaired. Reciprocal effects were also seen on body weight, as 5-HTT overexpressors were lighter and 5-HTT knockouts were heavier than wildtype controls. These findings show that variation in 5-HTT gene expression produces robust changes in anxiety and species-typical behaviour. Furthermore, the data add further support to findings that variation of 5-HTT expression in the human population is linked to changes in anxiety-related personality traits.show moreshow less

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Metadaten
Author: Samantha J. Line, Christopher Barkus, Clare Coyle, Katie A. Jennings, Robert M. Deacon, Klaus P. Lesch, Trevor Sharp, David M. Bannerman
URN:urn:nbn:de:bvb:20-opus-141222
Document Type:Journal article
Faculties:Medizinische Fakultät / Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie
Language:English
Parent Title (English):European Neuropsychopharmacology
Year of Completion:2011
Volume:21
Issue:1
Pagenumber:108-116
Source:European Neuropsychopharmacology (2011) 21, 108–116
DOI:https://doi.org/10.1016/j.euroneuro.2010.08.005
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:5-HT; 5-HT transporter; Anxiety; Body weight; Transgenic mice
Release Date:2019/01/09
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung