Phytic acid as alternative setting retarder enhanced biological performance of dicalcium phosphate cement in vitro

Please always quote using this URN: urn:nbn:de:bvb:20-opus-171047
  • Dicalcium phosphate cement preparation requires the addition of setting retarders to meet clinical requirements regarding handling time and processability. Previous studies have focused on the influence of different setting modifiers on material properties such as mechanical performance or injectability, while ignoring their influence on biological cement properties as they are used in low concentrations in the cement pastes and the occurrence of most compounds in human tissues. Here, analyses of both material and biological behavior wereDicalcium phosphate cement preparation requires the addition of setting retarders to meet clinical requirements regarding handling time and processability. Previous studies have focused on the influence of different setting modifiers on material properties such as mechanical performance or injectability, while ignoring their influence on biological cement properties as they are used in low concentrations in the cement pastes and the occurrence of most compounds in human tissues. Here, analyses of both material and biological behavior were carried out on samples with common setting retardants (citric acid, sodium pyrophosphate, sulfuric acid) and novel (phytic acid). Cytocompatibility was evaluated by in vitro tests with osteoblastic (hFOB 1.19) and osteoclastic (RAW 264.7) cells. We found cytocompatibility was better for sodium pyrophosphate and phytic acid with a three-fold cell metabolic activity by WST-1 test, whereas samples set with citric acid showed reduced cell number as well as cell activity. The compressive strength (CS) of cements formed with phytic acid (CS = 13 MPa) were nearly equal to those formed with citric acid (CS = 15 MPa) and approximately threefold higher than for other setting retardants. Due to a proven cytocompatibility and high mechanical strength, phytic acid seems to be a candidate replacement setting retardant for dicalcium phosphate cements.show moreshow less

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Metadaten
Author: Susanne Meininger, Carina Blum, Martha Schamel, Jake E. Barralet, Anita Ignatius, Uwe Gbureck
URN:urn:nbn:de:bvb:20-opus-171047
Document Type:Journal article
Faculties:Medizinische Fakultät / Abteilung für Funktionswerkstoffe der Medizin und der Zahnheilkunde
Language:English
Parent Title (English):Scientific Reports
Year of Completion:2017
Volume:7
Issue:558
Source:Scientific Reports 2017, 7:558. DOI: 10.1038/s41598-017-00731-6
DOI:https://doi.org/10.1038/s41598-017-00731-6
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=28373697
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:biomedical materials; dicalcium phosphate cement; implants; phytic acid
Release Date:2019/10/15
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International