Diverse facets of sphingolipid involvement in bacterial infections

Please always quote using this URN: urn:nbn:de:bvb:20-opus-201757
  • Sphingolipids are constituents of the cell membrane that perform various tasks as structural elements and signaling molecules, in addition to regulating many important cellular processes, such as apoptosis and autophagy. In recent years, it has become increasingly clear that sphingolipids and sphingolipid signaling play a vital role in infection processes. In many cases the attachment and uptake of pathogenic bacteria, as well as bacterial development and survival within the host cell depend on sphingolipids. In addition, sphingolipids canSphingolipids are constituents of the cell membrane that perform various tasks as structural elements and signaling molecules, in addition to regulating many important cellular processes, such as apoptosis and autophagy. In recent years, it has become increasingly clear that sphingolipids and sphingolipid signaling play a vital role in infection processes. In many cases the attachment and uptake of pathogenic bacteria, as well as bacterial development and survival within the host cell depend on sphingolipids. In addition, sphingolipids can serve as antimicrobials, inhibiting bacterial growth and formation of biofilms. This review will give an overview of our current information about these various aspects of sphingolipid involvement in bacterial infections.show moreshow less

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Metadaten
Author: Tobias C. Kunz, Vera Kozjak-Pavlovic
URN:urn:nbn:de:bvb:20-opus-201757
Document Type:Journal article
Faculties:Fakultät für Biologie / Theodor-Boveri-Institut für Biowissenschaften
Language:English
Parent Title (English):Frontiers in Cell and Developmental Biology
Year of Completion:2019
Volume:7
Issue:203
Source:Frontiers in Cell and Developmental Biology 2019, 7:203. doi: 10.3389/fcell.2019.00203
DOI:https://doi.org/10.3389/fcell.2019.00203
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:autophagy; ceramide; infection; pathogenic bacteria; sphingolipids
Release Date:2020/03/23
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International