Past and current perspectives in modeling bacteria and blood–brain barrier interactions

Please always quote using this URN: urn:nbn:de:bvb:20-opus-201766
  • The central nervous system (CNS) barriers are highly specialized cellular barriers that promote brain homeostasis while restricting pathogen and toxin entry. The primary cellular constituent regulating pathogen entry in most of these brain barriers is the brain endothelial cell (BEC) that exhibits properties that allow for tight regulation of CNS entry. Bacterial meningoencephalitis is a serious infection of the CNS and occurs when bacteria can cross specialized brain barriers and cause inflammation. Models have been developed to understand theThe central nervous system (CNS) barriers are highly specialized cellular barriers that promote brain homeostasis while restricting pathogen and toxin entry. The primary cellular constituent regulating pathogen entry in most of these brain barriers is the brain endothelial cell (BEC) that exhibits properties that allow for tight regulation of CNS entry. Bacterial meningoencephalitis is a serious infection of the CNS and occurs when bacteria can cross specialized brain barriers and cause inflammation. Models have been developed to understand the bacterial – BEC interaction that lead to pathogen crossing into the CNS, however, these have been met with challenges due to these highly specialized BEC phenotypes. This perspective provides a brief overview and outlook of the in vivo and in vitro models currently being used to study bacterial brain penetration, and opinion on improved models for the future.show moreshow less

Download full text files

Export metadata

Additional Services

Share in Twitter Search Google Scholar Statistics
Metadaten
Author: Brandon J. Kim, Eric V. Shusta, Kelly S. Doran
URN:urn:nbn:de:bvb:20-opus-201766
Document Type:Journal article
Faculties:Medizinische Fakultät / Institut für Hygiene und Mikrobiologie
Language:English
Parent Title (English):Frontiers in Microbiology
Year of Completion:2019
Volume:10
Issue:1336
Source:Frontiers in Microbiology 2019, 10:1336. doi: 10.3389/fmicb.2019.01336
DOI:https://doi.org/10.3389/fmicb.2019.01336
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:bacteria; blood–brain barrier; brain endothelial cell; meningitis; stem cells
Release Date:2020/03/23
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International