Improving printability of a thermoresponsive hydrogel biomaterial ink by nanoclay addition

Please always quote using this URN: urn:nbn:de:bvb:20-opus-234894
  • As a promising biofabrication technology, extrusion-based bioprinting has gained significant attention in the last decade and major advances have been made in the development of bioinks. However, suitable synthetic and stimuli-responsive bioinks are underrepresented in this context. In this work, we described a hybrid system of nanoclay Laponite XLG and thermoresponsive block copolymer poly(2-methyl-2-oxazoline)-b-poly(2-n-propyl-2-oxazine) (PMeOx-b-PnPrOzi) as a novel biomaterial ink and discussed its critical properties relevant forAs a promising biofabrication technology, extrusion-based bioprinting has gained significant attention in the last decade and major advances have been made in the development of bioinks. However, suitable synthetic and stimuli-responsive bioinks are underrepresented in this context. In this work, we described a hybrid system of nanoclay Laponite XLG and thermoresponsive block copolymer poly(2-methyl-2-oxazoline)-b-poly(2-n-propyl-2-oxazine) (PMeOx-b-PnPrOzi) as a novel biomaterial ink and discussed its critical properties relevant for extrusion-based bioprinting, including viscoelastic properties and printability. The hybrid hydrogel retains the thermogelling properties but is strengthened by the added clay (over 5 kPa of storage modulus and 240 Pa of yield stress). Importantly, the shear-thinning character is further enhanced, which, in combination with very rapid viscosity recovery (~ 1 s) and structure recovery (~ 10 s), is highly beneficial for extrusion-based 3D printing. Accordingly, various 3D patterns could be printed with markedly enhanced resolution and shape fidelity compared to the biomaterial ink without added clay.show moreshow less

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Metadaten
Author: Chen Hu, Lukas Hahn, Mengshi Yang, Alexander Altmann, Philipp Stahlhut, Jürgen Groll, Robert LuxenhoferORCiD
URN:urn:nbn:de:bvb:20-opus-234894
Document Type:Journal article
Faculties:Fakultät für Chemie und Pharmazie / Lehrstuhl für Chemische Technologie der Materialsynthese
Medizinische Fakultät / Abteilung für Funktionswerkstoffe der Medizin und der Zahnheilkunde
Language:English
Parent Title (English):Journal of Materials Science
ISSN:0022-2461
Year of Completion:2021
Volume:56
Pagenumber:691-705
Source:Journal of Materials Science 56, 691–705 (2021). https://doi.org/10.1007/s10853-020-05190-5
DOI:https://doi.org/10.1007/s10853-020-05190-5
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 54 Chemie / 542 Techniken, Ausstattung, Materialien
Tag:printability; thermoresponsive hydrogel
Release Date:2021/06/10
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International