Association of polygenic risk scores, traumatic life events and coping strategies with war-related PTSD diagnosis and symptom severity in the South Eastern Europe (SEE)-PTSD cohort

Please always quote using this URN: urn:nbn:de:bvb:20-opus-268541
  • Objectives Posttraumatic stress disorder (PTSD) is triggered by extremely stressful environmental events and characterized by high emotional distress, re-experiencing of trauma, avoidance and hypervigilance. The present study uses polygenic risk scores (PRS) derived from the UK Biobank (UKBB) mega-cohort analysis as part of the PGC PTSD GWAS effort to determine the heritable basis of PTSD in the South Eastern Europe (SEE)-PTSD cohort. We further analyzed the relation between PRS and additional disease-related variables, such as number andObjectives Posttraumatic stress disorder (PTSD) is triggered by extremely stressful environmental events and characterized by high emotional distress, re-experiencing of trauma, avoidance and hypervigilance. The present study uses polygenic risk scores (PRS) derived from the UK Biobank (UKBB) mega-cohort analysis as part of the PGC PTSD GWAS effort to determine the heritable basis of PTSD in the South Eastern Europe (SEE)-PTSD cohort. We further analyzed the relation between PRS and additional disease-related variables, such as number and intensity of life events, coping, sex and age at war on PTSD and CAPS as outcome variables. Methods Association of PRS, number and intensity of life events, coping, sex and age on PTSD were calculated using logistic regression in a total of 321 subjects with current and remitted PTSD and 337 controls previously subjected to traumatic events but not having PTSD. In addition, PRS and other disease-related variables were tested for association with PTSD symptom severity, measured by the Clinician Administrated PTSD Scale (CAPS) by liner regression. To assess the relationship between the main outcomes PTSD diagnosis and symptom severity, each of the examined variables was adjusted for all other PTSD related variables. Results The categorical analysis showed significant polygenic risk in patients with remitted PTSD and the total sample, whereas no effects were found on symptom severity. Intensity of life events as well as the individual coping style were significantly associated with PTSD diagnosis in both current and remitted cases. The dimensional analyses showed as association of war-related frequency of trauma with symptom severity, whereas the intensity of trauma yielded significant results independently of trauma timing in current PTSD. Conclusions The present PRS application in the SEE-PTSD cohort confirms modest but significant polygenic risk for PTSD diagnosis. Environmental factors, mainly the intensity of traumatic life events and negative coping strategies, yielded associations with PTSD both categorically and dimensionally with more significant p-values. This suggests that, at least in the present cohort of war-related trauma, the association of environmental factors and current individual coping strategies with PTSD psychopathology was stronger than the polygenic risk.show moreshow less

Download full text files

Export metadata

Additional Services

Share in Twitter Search Google Scholar Statistics
Metadaten
Author: Heike Weber, Adam X. Maihofer, Nenad Jaksic, Elma Feric Bojic, Sabina Kucukalic, Emina Sabic Dzananovic, Aferdita Goci Uka, Blerina Hoxha, Valdete Haxhibeqiri, Shpend Haxhibeqiri, Nermina Kravic, Mirnesa Muminovic Umihanic, Ana Cima Franc, Romana Babic, Marko Pavlovic, Alma Bravo Mehmedbasic, Branka Aukst-Margetic, Abdulah Kucukalic, Damir Marjanovic, Dragan Babic, Miro Jakovljevic, Osman Sinanovic, Esmina Avidbegović, Ferid Agani, Bodo Warrings, Katharina Domschke, Caroline M. Nievergelt, Alma Dzubur-Kulenovic, Angelika Erhardt
URN:urn:nbn:de:bvb:20-opus-268541
Document Type:Journal article
Faculties:Medizinische Fakultät / Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie
Language:English
Parent Title (English):Journal of Neural Transmission
ISSN:1435-1463
Year of Completion:2022
Volume:129
Issue:5-6
Pagenumber:661–674
Source:Journal of Neural Transmission 2022, 129(5-6):661–674. DOI: 10.1007/s00702-021-02446-5
DOI:https://doi.org/10.1007/s00702-021-02446-5
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=34837533
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:CAPS; PTSD; coping style; life events; polygenic risk score
Release Date:2022/09/21
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International