Amelioration of cognitive and behavioral deficits after traumatic brain injury in coagulation factor XII deficient mice

Please always quote using this URN: urn:nbn:de:bvb:20-opus-284959
  • Based on recent findings that show that depletion of factor XII (FXII) leads to better posttraumatic neurological recovery, we studied the effect of FXII-deficiency on post-traumatic cognitive and behavioral outcomes in female and male mice. In agreement with our previous findings, neurological deficits on day 7 after weight-drop traumatic brain injury (TBI) were significantly reduced in FXII\(^{−/−}\) mice compared to wild type (WT) mice. Also, glycoprotein Ib (GPIb)-positive platelet aggregates were more frequent in brain microvasculature ofBased on recent findings that show that depletion of factor XII (FXII) leads to better posttraumatic neurological recovery, we studied the effect of FXII-deficiency on post-traumatic cognitive and behavioral outcomes in female and male mice. In agreement with our previous findings, neurological deficits on day 7 after weight-drop traumatic brain injury (TBI) were significantly reduced in FXII\(^{−/−}\) mice compared to wild type (WT) mice. Also, glycoprotein Ib (GPIb)-positive platelet aggregates were more frequent in brain microvasculature of WT than FXII\(^{−/−}\) mice 3 months after TBI. Six weeks after TBI, memory for novel object was significantly reduced in both female and male WT but not in FXII\(^{−/−}\) mice compared to sham-operated mice. In the setting of automated home-cage monitoring of socially housed mice in IntelliCages, female WT mice but not FXII\(^{−/−}\) mice showed decreased exploration and reacted negatively to reward extinction one month after TBI. Since neuroendocrine stress after TBI might contribute to trauma-induced cognitive dysfunction and negative emotional contrast reactions, we measured peripheral corticosterone levels and the ration of heart, lung, and spleen weight to bodyweight. Three months after TBI, plasma corticosterone levels were significantly suppressed in both female and male WT but not in FXII\(^{−/−}\) mice, while the relative heart weight increased in males but not in females of both phenotypes when compared to sham-operated mice. Our results indicate that FXII deficiency is associated with efficient post-traumatic behavioral and neuroendocrine recovery.show moreshow less

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Metadaten
Author: Christian Stetter, Simon Lopez-Caperuchipi, Sarah Hopp-Krämer, Michael Bieber, Christoph Kleinschnitz, Anna-Leena Sirén, Christiane Albert-Weißenberger
URN:urn:nbn:de:bvb:20-opus-284959
Document Type:Journal article
Faculties:Medizinische Fakultät / Neurochirurgische Klinik und Poliklinik
Medizinische Fakultät / Physiologisches Institut
Medizinische Fakultät / Neurologische Klinik und Poliklinik
Language:English
Parent Title (English):International Journal of Molecular Sciences
ISSN:1422-0067
Year of Completion:2021
Volume:22
Issue:9
Article Number:4855
Source:International Journal of Molecular Sciences (2021) 22:9, 4855. https://doi.org/10.3390/ijms22094855
DOI:https://doi.org/10.3390/ijms22094855
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:Crespi effect; IntelliCage; closed head injury; contact-kinin system; object recognition memory; stress
Release Date:2023/06/26
Date of first Publication:2021/05/03
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International