Radiation inactivation analysis of the A\(_1\) adenosine receptor: decrease in radiation inactivation size in the presence of guanine nucleotide
Please always quote using this URN: urn:nbn:de:bvb:20-opus-60318
- Radiation inactivation analysis of the binding of the A1 adenosine receptor antagonist, 8-cyclopentyl-1,3-dipropylxanthine to rat brain membranes yielded a radiation inactivation size of 58 kDa. In the presence of GTPyS this was reduced to 33 kDa, in good agreement with the size of the ligand-binding subunit detected after photoaffinity labelling. The data indicate that the structural association of A\(_1\) adenosine receptors with G-protein components is altered in situ in the presence of guanine nucleotides.
| Author: | M. Reddington, Karl-Norbert Klotz, M. J. Lohse, B. Hietel |
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| URN: | urn:nbn:de:bvb:20-opus-60318 |
| Document Type: | Journal article |
| Faculties: | Medizinische Fakultät / Institut für Pharmakologie und Toxikologie |
| Language: | English |
| Year of Completion: | 1989 |
| Source: | FEBS Letters (1989) 1, 252, 125-128. |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| GND Keyword: | Toxikologie |
| Tag: | (Rat brain membrane); A1; Adenosine receptor; G-protein; Radiation inactivation; Target size |
| Release Date: | 2011/12/09 |
| Licence (German): |  Deutsches Urheberrecht |