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Experimental first-pass method for testing and comparing sorbent polymers used in the clearance of iodine contrast materials
Please always quote using this URN: urn:nbn:de:bvb:20-opus-199118
- Background: Sorbents have been shown to adsorb iodinated radiocontrast media. Objective: In this study we describe a simple method to compare various sorbents in terms of capacity to adsorb radiocontrast media. Methods: Iodixanol solution was injected into columns filled with three types of sorbent at filtration velocities of increasing magnitude. Two variables of interest – contrast removal rate and matched iodine retention (MIR) – were calculated to measure the adsorption efficiency and the mass of contrast iodine adsorbed versus sorbentBackground: Sorbents have been shown to adsorb iodinated radiocontrast media. Objective: In this study we describe a simple method to compare various sorbents in terms of capacity to adsorb radiocontrast media. Methods: Iodixanol solution was injected into columns filled with three types of sorbent at filtration velocities of increasing magnitude. Two variables of interest – contrast removal rate and matched iodine retention (MIR) – were calculated to measure the adsorption efficiency and the mass of contrast iodine adsorbed versus sorbent used, respectively. Results: The highest contrast removal and MIR for Porapak Q, CST 401 and Amberlite XAD4 were 41, 38 and 16% (p = 0.22 and 0.0005 for comparisons between Porapak Q-CST 401 and CST 401-Amberlite XAD4) and 0.060, 0.055 and 0.024, respectively (p = 0.18 and 0.0008). Extrapolation to a clinical scenario may suggest that removal of 8 ml iodixanol could be achieved by masses of sorbents of 43, 47 and 107 g, respectively. Conclusion: In this study we set a benchmark for comparing the radiocontrast-adsorbing efficiency of polymer sorbents during first-pass experiments, using a readily available methodology.…
Author: | George O. Angheloiu, Heribert Hänscheid, Xiaoyan Wen, Vincent Capponi, William D. Anderson, John A. Kellum |
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URN: | urn:nbn:de:bvb:20-opus-199118 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Klinik und Poliklinik für Nuklearmedizin |
Language: | English |
Parent Title (English): | Blood Purification |
ISSN: | 0253-5068 |
ISSN: | 1421-9735 |
Year of Completion: | 2012 |
Volume: | 34 |
Issue: | 1 |
Pagenumber: | 34-39 |
Source: | Blood Purification (2021) 34:1, 34-39. DOI: 10.1159/000339816 |
DOI: | https://doi.org/10.1159/000339816 |
Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/22907199 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Tag: | acute renal failure; adsorption; iodine contrast; sorbents |
Release Date: | 2022/12/13 |
Date of first Publication: | 2012/08/17 |
Note: | Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. |
Licence (German): | Deutsches Urheberrecht |