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The Role of Sphingomyelin Breakdown in Measles Virus Immunmodulation
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-120004
- Measles virus (MV) efficiently causes generalized immunosuppression which accounts to a major extent for cases of measles-asscociated severe morbidity and mortality. MV infections alter many functions of antigen presenting cells (APC) (dendritic cells (DCs)) and lymphocytes, yet many molecular targets of the virus remain poorly defined. Cellular interactions and effector functions of DCs and lymphocytes are regulated by surface receptors. Associating with other proteins involved in cell signaling, receptors form part of receptosomes thatMeasles virus (MV) efficiently causes generalized immunosuppression which accounts to a major extent for cases of measles-asscociated severe morbidity and mortality. MV infections alter many functions of antigen presenting cells (APC) (dendritic cells (DCs)) and lymphocytes, yet many molecular targets of the virus remain poorly defined. Cellular interactions and effector functions of DCs and lymphocytes are regulated by surface receptors. Associating with other proteins involved in cell signaling, receptors form part of receptosomes that respond to and transmit external signals through dynamic interctions with the cytoskeleton. Alterations in the composition and metabolism of membrane sphingolipids have a substantial impact on both processes. In this review we focus on the regulation of sphingomyelinase activity and ceramide release in cells exposed to MV and discuss the immunosuppressive role of sphingomyelin breakdown induced by MV.…
Autor(en): | Elita Avota, Sibylle Schneider-Schaulies |
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URN: | urn:nbn:de:bvb:20-opus-120004 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Institut für Virologie und Immunbiologie |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Cellular Physiology and Biochemistry |
ISSN: | 1015-8987 |
Erscheinungsjahr: | 2014 |
Band / Jahrgang: | 34 |
Heft / Ausgabe: | 1 |
Seitenangabe: | 20-26 |
Originalveröffentlichung / Quelle: | Cellular Physiology and Biochemistry 2014;34:20-26. DOI:10.1159/000362981 |
DOI: | https://doi.org/10.1159/000362981 |
PubMed-ID: | https://pubmed.ncbi.nlm.nih.gov/24977478 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 579 Mikroorganismen, Pilze, Algen |
Freie Schlagwort(e): | T cell silencing; dendritic cell; immunosuppression; measles virus; sphingomyelinase |
Datum der Freischaltung: | 25.11.2015 |
Lizenz (Deutsch): | CC BY-NC: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell |