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Assessment of reproductive and developmental effects of DINP, DnHP and DCHP using quantitative weight of evidence

Please always quote using this URN: urn:nbn:de:bvb:20-opus-186750
  • Quantitative weight of evidence (QWoE) methodology utilizes detailed scoring sheets to assess the quality/reliability of each publication on toxicity of a chemical and gives numerical scores for quality and observed toxicity. This QWoE-methodology was applied to the reproductive toxicity data on diisononylphthalate (DINP), di-n-hexylphthalate (DnHP), and dicyclohexylphthalate (DCHP) to determine if the scientific evidence for adverse effects meets the requirements for classification as reproductive toxicants. The scores for DINP were comparedQuantitative weight of evidence (QWoE) methodology utilizes detailed scoring sheets to assess the quality/reliability of each publication on toxicity of a chemical and gives numerical scores for quality and observed toxicity. This QWoE-methodology was applied to the reproductive toxicity data on diisononylphthalate (DINP), di-n-hexylphthalate (DnHP), and dicyclohexylphthalate (DCHP) to determine if the scientific evidence for adverse effects meets the requirements for classification as reproductive toxicants. The scores for DINP were compared to those when applying the methodology DCHP and DnHP that have harmonized classifications. Based on the quality/reliability scores, application of the QWoE shows that the three databases are of similar quality; but effect scores differ widely. Application of QWoE to DINP studies resulted in an overall score well below the benchmark required to trigger classification. For DCHP, the QWoE also results in low scores. The high scores from the application of the QWoE methodology to the toxicological data for DnHP represent clear evidence for adverse effects and justify a classification of DnHP as category 1B for both development and fertility. The conclusions on classification based on the QWoE are well supported using a narrative assessment of consistency and biological plausibility.show moreshow less

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Metadaten
Author: Wolfgang Dekant, James Bridges
URN:urn:nbn:de:bvb:20-opus-186750
Document Type:Journal article
Faculties:Medizinische Fakultät / Institut für Pharmakologie und Toxikologie
Language:English
Parent Title (English):Regulatory Toxicology and Pharmacology
Year of Completion:2016
Volume:81
Pagenumber:397-406
Source:Regulatory Toxicology and Pharmacology (2016) 81, 397-406. https://doi.org/10.1016/j.yrtph.2016.09.032
DOI:https://doi.org/10.1016/j.yrtph.2016.09.032
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:2-Generation reproduction; Diisononyl phthalate; classification and labeling; dicyclohexyl phthalate; fetal testis; in-vivo; male rats; n-hexyl phthalate; quantitative assessments; reproductive and developmental toxicity; risk-assesment; sexual development; testosterone production; weight of evidence
Release Date:2020/05/27
Licence (German):License LogoCC BY-NC-ND: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell, Keine Bearbeitungen 4.0 International