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Human Tuberculous Meningitis Caused by \(Mycobacterium\) \(caprae\)

Please always quote using this URN: urn:nbn:de:bvb:20-opus-123425
  • INTRODUCTION: Tuberculous meningitis (TM) causes substantial morbidity and mortality in humans. Human TM has been known to be induced by bacteria from the Mycobacterium tuberculosis complex (MTBC), such as M. tuberculosis and M. bovis. CASE PRESENTATION: We describe a case of meningitis treated with fosfomycin, which showed partial effectiveness in an 80-year-old patient. After a lethal myocardial infarction, M. caprae (MC) was identified in cerebrospinal fluid culture. This isolated acid-fast organism was first identified as MTBC byINTRODUCTION: Tuberculous meningitis (TM) causes substantial morbidity and mortality in humans. Human TM has been known to be induced by bacteria from the Mycobacterium tuberculosis complex (MTBC), such as M. tuberculosis and M. bovis. CASE PRESENTATION: We describe a case of meningitis treated with fosfomycin, which showed partial effectiveness in an 80-year-old patient. After a lethal myocardial infarction, M. caprae (MC) was identified in cerebrospinal fluid culture. This isolated acid-fast organism was first identified as MTBC by MTBC-specific PCR (16S rDNA-PCR). Furthermore, species-specific identification of the isolate was done by gyrB PCR-restriction fragment length polymorphism analysis of a part of gyrB DNA. Colony morphology of the isolated MC strain showed dysgonic growth on Lowenstein-Jensen medium. The strain was susceptible to pyrazinamide (PZA). CONCLUSION: This isolated strain was convincingly identified as MC according to the phenotypic and genotypic characteristics and PZA sensitivity. This is the first report of MC causing TM.show moreshow less

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Metadaten
Author: Niels Hansen, Carola Seiler, Julian Rumpf, Peter Kraft, Henry Dlaske, Marianne Abele-Horn, Wolfgang Muellges
URN:urn:nbn:de:bvb:20-opus-123425
Document Type:Journal article
Faculties:Medizinische Fakultät / Neurologische Klinik und Poliklinik
Language:English
Parent Title (English):Case Reports in Neurology
Year of Completion:2012
Volume:4
Issue:1
Pagenumber:54-60
Source:Case Reports in Neurology. 4(1):54-60. DOI:10.1159/000337299
DOI:https://doi.org/10.1159/000337299
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=PMC3335363
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 616 Krankheiten
Tag:Mycobacterium caprae; Tuberkulose
Mycobacterium caprae; Mycobacterium tuberculosis complex; cerebrospinal fluid culture; fosfomycin; tuberculous meningitis
Release Date:2015/12/21
Licence (German):License LogoCC BY-NC-ND: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell, Keine Bearbeitung