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Anti-Schistosomal Activity of Cinnamic Acid Esters: Eugenyl

Please always quote using this URN: urn:nbn:de:bvb:20-opus-125712
  • Bornyl caffeate (1) was previously isolated by us from Valeriana (V.) wallichii rhizomes and identified as an anti-leishmanial substance. Here, we screened a small compound library of synthesized derivatives 1–30 for activity against schistosomula of Schistosoma (S.) mansoni. Compound 1 did not show any anti-schistosomal activity. However, strong phenotypic changes, including the formation of vacuoles, degeneration and death were observed after in vitro treatment with compounds 23 (thymyl cinnamate) and 27 (eugenyl cinnamate). ElectronBornyl caffeate (1) was previously isolated by us from Valeriana (V.) wallichii rhizomes and identified as an anti-leishmanial substance. Here, we screened a small compound library of synthesized derivatives 1–30 for activity against schistosomula of Schistosoma (S.) mansoni. Compound 1 did not show any anti-schistosomal activity. However, strong phenotypic changes, including the formation of vacuoles, degeneration and death were observed after in vitro treatment with compounds 23 (thymyl cinnamate) and 27 (eugenyl cinnamate). Electron microscopy analysis of the induced vacuoles in the dying parasites suggests that 23 and 27 interfere with autophagy.show moreshow less

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Metadaten
Author: Jan Glaser, Uta Schurigt, Brian M. Suzuki, Connor R. Caffrey, Ulrike Holzgrabe
URN:urn:nbn:de:bvb:20-opus-125712
Document Type:Journal article
Faculties:Medizinische Fakultät / Institut für Molekulare Infektionsbiologie
Fakultät für Chemie und Pharmazie / Institut für Pharmazie und Lebensmittelchemie
Language:English
Parent Title (English):Molecules
Year of Completion:2015
Volume:20
Pagenumber:10873-10883
Source:Molecules 2015, 20, 10873-10883; doi:10.3390/molecules200610873
DOI:https://doi.org/10.3390/molecules200610873
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:anti-schistosomal activity; autophagy; eugenyl cinnamate; parasite; schistosoma; schistosomula; thymyl cinnamate; vacuoles
Release Date:2016/02/02
Collections:Open-Access-Publikationsfonds / Förderzeitraum 2015
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung