Cryptochrome interacts with actin and enhances eye-mediated light sensitivity of the circadian clock in Drosophila melanogaster
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-177086
- Cryptochromes (CRYs) are a class of flavoproteins that sense blue light. In animals, CRYs are expressed in the eyes and in the clock neurons that control sleep/wake cycles and are implied in the generation and/or entrainment of circadian rhythmicity. Moreover, CRYs are sensing magnetic fields in insects as well as in humans. Here, we show that in the fruit fly Drosophila melanogaster CRY plays a light-independent role as “assembling” protein in the rhabdomeres of the compound eyes. CRY interacts with actin and appears to increase lightCryptochromes (CRYs) are a class of flavoproteins that sense blue light. In animals, CRYs are expressed in the eyes and in the clock neurons that control sleep/wake cycles and are implied in the generation and/or entrainment of circadian rhythmicity. Moreover, CRYs are sensing magnetic fields in insects as well as in humans. Here, we show that in the fruit fly Drosophila melanogaster CRY plays a light-independent role as “assembling” protein in the rhabdomeres of the compound eyes. CRY interacts with actin and appears to increase light sensitivity of the eyes by keeping the “signalplex” of the phototransduction cascade close to the membrane. By this way, CRY also enhances light-responses of the circadian clock.…
Autor(en): | Matthias Schlichting, Dirk Rieger, Paola Cusumano, Rudi Grebler, Rodolfo Costa, Gabriella M. Mazzotta, Charlotte Helfrich-Förster |
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URN: | urn:nbn:de:bvb:20-opus-177086 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Fakultät für Biologie / Theodor-Boveri-Institut für Biowissenschaften |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Frontiers in Molecular Neuroscience |
Erscheinungsjahr: | 2018 |
Band / Jahrgang: | 11 |
Heft / Ausgabe: | 238 |
Originalveröffentlichung / Quelle: | Frontiers in Molecular Neuroscience 2018, Volume 11, Article 238. DOI: 10.3389/fnmol.2018.00238 |
DOI: | https://doi.org/10.3389/fnmol.2018.00238 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
Freie Schlagwort(e): | Drosophila melanogaster; F-actin; activity rhythms; cryptochrome; phototransduction |
Datum der Freischaltung: | 27.02.2019 |
EU-Projektnummer / Contract (GA) number: | 018741 |
OpenAIRE: | OpenAIRE |
Sammlungen: | Open-Access-Publikationsfonds / Förderzeitraum 2018 |
Lizenz (Deutsch): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |