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Alloreactivity of virus-specific T cells: possible implication of graft-versus-host disease and graft-versus-leukemia effects

Please always quote using this URN: urn:nbn:de:bvb:20-opus-129260
  • Immune reconstitution of functional virus-specific T cells after allogeneic hematopoietic stem cell transplantation (HSCT) has been intensively investigated. However, the possible role of crossreactivity of these virus-specific T cells against allogeneic targets is still unclear. Theoretically, as in the field of organ transplantation, virus-specific T cells possess crossreactivity potential after allogeneic HSCT. Such crossreactivity is assumed to play a role in graft-versus-host disease and graft-versus-leukemia effects. In this article, weImmune reconstitution of functional virus-specific T cells after allogeneic hematopoietic stem cell transplantation (HSCT) has been intensively investigated. However, the possible role of crossreactivity of these virus-specific T cells against allogeneic targets is still unclear. Theoretically, as in the field of organ transplantation, virus-specific T cells possess crossreactivity potential after allogeneic HSCT. Such crossreactivity is assumed to play a role in graft-versus-host disease and graft-versus-leukemia effects. In this article, we aim to give a comprehensive overview of current understanding about crossreactivity of virus-specific T cells.show moreshow less

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Metadaten
Author: Shigeo Fuji, Markus Kapp, Hermann Einsele
URN:urn:nbn:de:bvb:20-opus-129260
Document Type:Journal article
Faculties:Medizinische Fakultät / Medizinische Klinik und Poliklinik II
Language:English
Parent Title (English):Frontiers in Immunology
Year of Completion:2013
Volume:4
Issue:330
Source:Frontiers in Immunology 4:330. doi: 10.3389/fimmu.2013.00330
DOI:https://doi.org/10.3389/fimmu.2013.00330
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:GVHD; GVL; HLA antigens; allogeneic stem cell transplantation; mismatch; virus-specific T-cell
Release Date:2016/06/22
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung