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Acute Muscle Trauma due to Overexercise in an Otherwise Healthy Patient with Cystic Fibrosis

Please always quote using this URN: urn:nbn:de:bvb:20-opus-123967
  • Cystic fibrosis (CF) is one of the most common inherited diseases and is caused by mutations in the CFTR gene. Although the pulmonary and gastrointestinal manifestations of the disease remain in the focus of treatment, recent studies have shown expression of the CFTR gene product in skeletal muscle cells and observed altered intramuscular \(Ca^{2+}\) release dynamics in CFTR-deficient animal models. Physical exercise is beneficial for maintaining fitness and well-being in CF patients and constitutes one aspect of modern multimodal treatment,Cystic fibrosis (CF) is one of the most common inherited diseases and is caused by mutations in the CFTR gene. Although the pulmonary and gastrointestinal manifestations of the disease remain in the focus of treatment, recent studies have shown expression of the CFTR gene product in skeletal muscle cells and observed altered intramuscular \(Ca^{2+}\) release dynamics in CFTR-deficient animal models. Physical exercise is beneficial for maintaining fitness and well-being in CF patients and constitutes one aspect of modern multimodal treatment, which has considerably increased life span and reduced morbidity. We report on a case of acute muscle trauma resulting from excessive dumbbell exercise in a young adult with cystic fibrosis and describe clinical, laboratory and imaging characteristics of acute exercise-induced muscle injury.show moreshow less

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Metadaten
Author: Henning Neubauer, Clemens Wirth, Katharina Ruf, Helge Hebestreit, Meinrad Beer
URN:urn:nbn:de:bvb:20-opus-123967
Document Type:Journal article
Faculties:Medizinische Fakultät / Kinderklinik und Poliklinik
Medizinische Fakultät / Institut für diagnostische und interventionelle Radiologie (Institut für Röntgendiagnostik)
Language:English
Parent Title (English):Case Reports in Pediatrics
Year of Completion:2012
Volume:2012
Issue:527989
Source:Case Reports in Pediatrics 2012 Article ID 527989. doi:10.1155/2012/527989
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=PMC3350114
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 618 Gynäkologie, Geburtsmedizin, Pädiatrie, Geriatrie
Tag:Cystic fibrosis
Release Date:2016/01/12
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung