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cAMP Signals in Drosophila Motor Neurons Are Confined to Single Synaptic Boutons

Please always quote using this URN: urn:nbn:de:bvb:20-opus-162324
  • The second messenger cyclic AMP (cAMP) plays an important role in synaptic plasticity. Although there is evidence for local control of synaptic transmission and plasticity, it is less clear whether a similar spatial confinement of cAMP signaling exists. Here, we suggest a possible biophysical basis for the site-specific regulation of synaptic plasticity by cAMP, a highly diffusible small molecule that transforms the physiology of synapses in a local and specific manner. By exploiting the octopaminergic system of Drosophila, which mediatesThe second messenger cyclic AMP (cAMP) plays an important role in synaptic plasticity. Although there is evidence for local control of synaptic transmission and plasticity, it is less clear whether a similar spatial confinement of cAMP signaling exists. Here, we suggest a possible biophysical basis for the site-specific regulation of synaptic plasticity by cAMP, a highly diffusible small molecule that transforms the physiology of synapses in a local and specific manner. By exploiting the octopaminergic system of Drosophila, which mediates structural synaptic plasticity via a cAMP-dependent pathway, we demonstrate the existence of local cAMP signaling compartments of micrometer dimensions within single motor neurons. In addition, we provide evidence that heterogeneous octopamine receptor localization, coupled with local differences in phosphodiesterase activity, underlies the observed differences in cAMP signaling in the axon, cell body, and boutons.show moreshow less

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Metadaten
Author: Isabella Maiellaro, Martin J. Lohse, Robert J. Kitte, Davide Calebiro
URN:urn:nbn:de:bvb:20-opus-162324
Document Type:Journal article
Faculties:Medizinische Fakultät / Institut für Pharmakologie und Toxikologie
Medizinische Fakultät / Physiologisches Institut
Fakultät für Biologie / Rudolf-Virchow-Zentrum
Language:English
Parent Title (English):Cell Reports
Year of Completion:2016
Volume:17
Issue:5
Pagenumber:1238-1246
Source:Cell Reports 17, 1238–1246 doi:10.1016/j.celrep.2016.09.090
DOI:https://doi.org/10.1016/j.celrep.2016.09.090
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 612 Humanphysiologie
Tag:FRET; GPCR; PDE; active zone; cAMP; dunce; octopamine; synaptic plasticity
Release Date:2018/07/13
EU-Project number / Contract (GA) number:324612
OpenAIRE:OpenAIRE
Licence (German):License LogoCC BY-NC-ND: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell, Keine Bearbeitungen 4.0 International