Salmonella - how a metabolic generalist adopts an intracellular lifestyle during infection
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-149029
- The human-pathogenic bacterium Salmonella enterica adjusts and adapts to different environments while attempting colonization. In the course of infection nutrient availabilities change drastically. New techniques, "-omics" data and subsequent integration by systems biology improve our understanding of these changes. We review changes in metabolism focusing on amino acid and carbohydrate metabolism. Furthermore, the adaptation process is associated with the activation of genes of the Salmonella pathogenicity islands (SPIs). Anti-infectiveThe human-pathogenic bacterium Salmonella enterica adjusts and adapts to different environments while attempting colonization. In the course of infection nutrient availabilities change drastically. New techniques, "-omics" data and subsequent integration by systems biology improve our understanding of these changes. We review changes in metabolism focusing on amino acid and carbohydrate metabolism. Furthermore, the adaptation process is associated with the activation of genes of the Salmonella pathogenicity islands (SPIs). Anti-infective strategies have to take these insights into account and include metabolic and other strategies. Salmonella infections will remain a challenge for infection biology.…
Autor(en): | Thomas Dandekar, Astrid Fieselmann, Eva Fischer, Jasmin Popp, Michael Hensel, Janina Noster |
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URN: | urn:nbn:de:bvb:20-opus-149029 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Fakultät für Biologie / Theodor-Boveri-Institut für Biowissenschaften |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Frontiers in Cellular and Infection Microbiology |
Erscheinungsjahr: | 2015 |
Band / Jahrgang: | 4 |
Heft / Ausgabe: | 191 |
Originalveröffentlichung / Quelle: | Frontiers in Cellular and Infection Microbiology 4:191 (2015). DOI: 10.3389/fcimb.2014.00191 |
DOI: | https://doi.org/10.3389/fcimb.2014.00191 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Freie Schlagwort(e): | "-omics"; Salmonella-containing vacuole (SCV); bacterial invasion; defenses; enterica serovar Typhimurium; metabolism; mouse model; nitric oxide; regulation; virulence |
Datum der Freischaltung: | 23.11.2018 |
Lizenz (Deutsch): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |