Characterization of the env gene and of two novel coding regions of the human spumaretrovirus
Please always quote using this URN: urn:nbn:de:bvb:20-opus-86334
- Recombinant clones harboring retroviral DNA were established. The nucleotide sequence of the central and 3' region of the genome of the human spumaretrovirus was determined. The 5' end of the deduced protein sequence was homologaus to the endonuclease domain of retroviral reverse transcriptases. A small intergenic region is followed by a lang open reading frame of 985 aminoacid residues that according to its genomic location and structural features is a typical retroviral env gene. Surprisingly, the postenv region contains two open readingRecombinant clones harboring retroviral DNA were established. The nucleotide sequence of the central and 3' region of the genome of the human spumaretrovirus was determined. The 5' end of the deduced protein sequence was homologaus to the endonuclease domain of retroviral reverse transcriptases. A small intergenic region is followed by a lang open reading frame of 985 aminoacid residues that according to its genomic location and structural features is a typical retroviral env gene. Surprisingly, the postenv region contains two open reading frames that encodes two novel retroviral genes, termed bel-l and bel-2. The 3' LTR is 963 nucleotides lang and contains the signal sequences characteristic for transcriptional regulation of retrovirus genomes.…
Author: | B. Maurer, H. Bannert, Axel Rethwilm, B. Darai, R. M. Flügel |
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URN: | urn:nbn:de:bvb:20-opus-86334 |
Document Type: | Conference Proceeding |
Faculties: | Medizinische Fakultät / Institut für Virologie und Immunbiologie |
Language: | English |
Year of Completion: | 1988 |
Source: | In: Human Retroviruses, cancer, and aids / ed. Dani Bolognesi. - New York: Liss, 1988.- S. 75-88. - (Symposium on Molecular and Cellular Biology: UCLA Symposia on Molecular and Cellular Biology / New ser. ; 71. ). - ISBN 0-8451-2670-9 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
GND Keyword: | Spumaviren |
Release Date: | 2014/06/12 |
Licence (German): | Deutsches Urheberrecht |