High-risk human papillomavirus infection in Bowen’s disease of the nail unit: report of three cases and review of the literature
Please always quote using this URN: urn:nbn:de:bvb:20-opus-196638
- Background: Bowen’s disease (BD) of the nail unit is associated with human papillomavirus (HPV) infection. Objective: This study aimed to investigate the frequency of high-risk HPV infection, gender, age and digital distribution in this condition. Methods: Biopsy specimens of 3 consecutive cases with periungual BD were investigated for the presence of HPV DNA by in situ hybridization and by polymerase chain reaction (PCR). Furthermore, 74 cases of ungual BD conducted with HPV genotyping as reported in the literature were reviewed. Results:Background: Bowen’s disease (BD) of the nail unit is associated with human papillomavirus (HPV) infection. Objective: This study aimed to investigate the frequency of high-risk HPV infection, gender, age and digital distribution in this condition. Methods: Biopsy specimens of 3 consecutive cases with periungual BD were investigated for the presence of HPV DNA by in situ hybridization and by polymerase chain reaction (PCR). Furthermore, 74 cases of ungual BD conducted with HPV genotyping as reported in the literature were reviewed. Results: PCR of biopsy specimens revealed in 2 cases infection with HPV-16 and in 1 case with HPV-73. Additionally, in 1 HPV-16-positive case HPV-31/33 was detected by in situ hybridization. In line, review of the literature demonstrated a clear association of HPV-positive BD with high-risk HPV types. Interestingly, age at diagnosis was significantly lower in women. Whereas in both genders the second to fourth fingers on both hands were commonly diseased, only in men the thumbs were also prominently affected. Conclusions: Infection with high-risk HPV types is common in BD of the nail unit suggesting the aetiological cause. Therefore, patients and partners should be closely followed up for digital and genital HPV-associated lesions.…
Author: | Natalie Grundmeier, Henning Hamm, Benedikt Weissbrich, Sabrina Christine Lang, Eva-Bettina Bröcker, Andreas Kerstan |
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URN: | urn:nbn:de:bvb:20-opus-196638 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Institut für Virologie und Immunbiologie |
Medizinische Fakultät / Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie | |
Language: | English |
Parent Title (English): | Dermatology |
ISSN: | 1018-8665 |
ISSN: | 1421-9832 |
Year of Completion: | 2012 |
Volume: | 223 |
Issue: | 4 |
First Page: | 293 |
Last Page: | 300 |
Source: | Dermatology (2012) 223:4, 293-300. https://doi.org/10.1159/000335371 |
DOI: | https://doi.org/10.1159/000335371 |
Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/22269697 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Tag: | Bowen’s disease, periungual; Human papillomavirus; Nail unit |
Release Date: | 2022/03/23 |
Date of first Publication: | 2012/01/24 |
Note: | This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively. |
Licence (German): | Deutsches Urheberrecht |