Formin’ cellular structures: Physiological roles of Diaphanous (Dia) in actin dynamics
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- Members of the Diaphanous (Dia) protein family are key regulators of fundamental actin driven cellular processes, which are conserved from yeast to humans. Researchers have uncovered diverse physiological roles in cell morphology, cell motility, cell polarity, and cell division, which are involved in shaping cells into tissues and organs. The identification of numerous binding partners led to substantial progress in our understanding of the differential functions of Dia proteins. Genetic approaches and new microscopy techniques allow importantMembers of the Diaphanous (Dia) protein family are key regulators of fundamental actin driven cellular processes, which are conserved from yeast to humans. Researchers have uncovered diverse physiological roles in cell morphology, cell motility, cell polarity, and cell division, which are involved in shaping cells into tissues and organs. The identification of numerous binding partners led to substantial progress in our understanding of the differential functions of Dia proteins. Genetic approaches and new microscopy techniques allow important new insights into their localization, activity, and molecular principles of regulation.…
Autor(en): | Sven Bogdan, Jörg Schultz, Jörg Grosshans |
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URN: | urn:nbn:de:bvb:20-opus-121305 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Fakultät für Biologie / Theodor-Boveri-Institut für Biowissenschaften |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Communicative & Integrative Biology |
Erscheinungsjahr: | 2013 |
Band / Jahrgang: | 6 |
Heft / Ausgabe: | e27634 |
Originalveröffentlichung / Quelle: | Communicative & Integrative Biology 6:6, e27634; http://dx.doi.org/10.4161/cib.27634 |
DOI: | https://doi.org/10.4161/cib.27634 |
PubMed-ID: | https://pubmed.ncbi.nlm.nih.gov/24719676 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
Freie Schlagwort(e): | Drosophila; actin; cytoskeleton; development; formin; nucleator |
Datum der Freischaltung: | 18.02.2016 |
Lizenz (Deutsch): | CC BY-NC: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell |