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Hematological effects of the new immunosuppressive drug 15-deoxyspergualin
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-44701
- Since systematic hematological studies on blood and bone marrow changes after treatment with 15-Deoxyspergualin (DOS) are lacking, a quantitative assessment was performed fourteen or twenty eight days after intraperitoneal application of DOS to rats. Further observations done 7 and 14 days after discontinuation of DOS administration allowed analysis of banc marrow regeneration. DOS induced lymphocytopenia, granUlocytopenia and anemia with a decrease of bone marrow cellularity due to suppression of cell maturation. The effect was dose-dependentSince systematic hematological studies on blood and bone marrow changes after treatment with 15-Deoxyspergualin (DOS) are lacking, a quantitative assessment was performed fourteen or twenty eight days after intraperitoneal application of DOS to rats. Further observations done 7 and 14 days after discontinuation of DOS administration allowed analysis of banc marrow regeneration. DOS induced lymphocytopenia, granUlocytopenia and anemia with a decrease of bone marrow cellularity due to suppression of cell maturation. The effect was dose-dependent and bone marrow as well as blood changes were observed in animals treated with doses from 0.5 to 10.0 mg/kg DOS. Within 14 days after termination of the treatment, rapid recovery with normalization of all hematological parameters was observed. In the light of our data, these hematological side effects may not be a major disadvantage, if DOS is used in doses below 2.5 mg/kg, and for a course of therapy which is limited to 7 to 14 days.…
Autor(en): | AM Waaga, M. Krzymanski, Karin Ulrichs, Bogna Wierusz-Wysocka, Wolfgang Müller-Buchholtz |
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URN: | urn:nbn:de:bvb:20-opus-44701 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I) |
Sprache der Veröffentlichung: | Englisch |
Erscheinungsjahr: | 1993 |
Originalveröffentlichung / Quelle: | In: Archivum immunologiae et therapiae experimentalis (1993) 41, 2, 141-146. |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Normierte Schlagworte (GND): | Chirurgie |
Freie Schlagwort(e): | 15-Deoxyspergualin; bone marrow; experimental therapy; hematology; immunosuppression; regeneration |
Datum der Freischaltung: | 19.10.2010 |
Lizenz (Deutsch): | Deutsches Urheberrecht |