Sila-Pharmaka, 26. Mitt. [1] Darstellung und Eigenschaften potentiell curarewirksamer Silicium-Verbindungen, III
Sila-Pharmaca, 26th Communication [1] Preparation and Properties of Silicon Compounds with Potential Curare-Like Activity, III
Please always quote using this URN: urn:nbn:de:bvb:20-opus-128402
- The potentially curare-like silicon compounds 8a- 8f were synthesized and investigated with respect to their structure-activity relationships. The conformations of the compounds in the solid state and in solution were studied by X-ray diffraction analysis (8a- 8e) and IR NMR spectroscopy (8a- 8f), respectively. The muscle relaxing properties of 8a- 8f were investigated on the mouse. The observed structure-activity relationships are not in accordance with the classical "14 Å model" for neuromuscular blocking agents.
| Author: | Reinhold Tacke, Haryanto Linoh, Moayad T. Attar-Bashi, William S. Sheldrick, Ludger Ernst, Roland Niedner, Joachim Frohnecke |
|---|---|
| URN: | urn:nbn:de:bvb:20-opus-128402 |
| Document Type: | Journal article |
| Faculties: | Fakultät für Chemie und Pharmazie / Institut für Anorganische Chemie |
| Language: | German |
| Parent Title (German): | Zeitschrift für Naturforschung B |
| Year of Completion: | 1982 |
| Volume: | 37 |
| Issue: | 11 |
| Pagenumber: | 1461-1471 |
| Source: | Zeitschrift für Naturforschung B 37, 1461- 1471 (1982) |
| Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 546 Anorganische Chemie |
| Tag: | X-ray; conformational anaylses; curare-lik activity; silicon compounds; structure-activity relationships |
| Release Date: | 2016/03/01 |
| Licence (German): |  Deutsches Urheberrecht |