Modeling infectious diseases and host-microbe interactions in gastrointestinal organoids
Please always quote using this URN: urn:nbn:de:bvb:20-opus-138788
- Advances in stem cell research have allowed the development of 3-dimensional (3D) primary cell cultures termed organoid cultures, as they closely mimic the in vivo organization of different cell lineages. Bridging the gap between 2-dimensional (2D) monotypic cancer cell lines and whole organisms, organoids are now widely applied to model development and disease. Organoids hold immense promise for addressing novel questions in host-microbe interactions, infectious diseases and the resulting inflammatory conditions. Researchers have started toAdvances in stem cell research have allowed the development of 3-dimensional (3D) primary cell cultures termed organoid cultures, as they closely mimic the in vivo organization of different cell lineages. Bridging the gap between 2-dimensional (2D) monotypic cancer cell lines and whole organisms, organoids are now widely applied to model development and disease. Organoids hold immense promise for addressing novel questions in host-microbe interactions, infectious diseases and the resulting inflammatory conditions. Researchers have started to use organoids for modeling infection with pathogens, such as Helicobacter pylori or Salmonella enteritica, gut- microbiota interactions and inflammatory bowel disease. Future studies will broaden the spectrum of microbes used and continue to establish organoids as a standard model for human host-microbial interactions. Moreover, they will increasingly exploit the unique advantages of organoids, for example to address patient-specific responses to microbes.…
Author: | Sina Bartfeld |
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URN: | urn:nbn:de:bvb:20-opus-138788 |
Document Type: | Preprint |
Faculties: | Medizinische Fakultät / Institut für Molekulare Infektionsbiologie |
Language: | English |
Parent Title (English): | Developmental Biology |
ISSN: | 0012-1606 |
Year of Completion: | 2016 |
Source: | Developmental Biology, http://dx.doi.org/10.1016/j.ydbio.2016.09.014 |
URL: | http://www.sciencedirect.com/science/article/pii/S0012160616304602 |
DOI: | https://doi.org/http://dx.doi.org/10.1016/j.ydbio.2016.09.014 |
Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/27640087 |
Sonstige beteiligte Institutionen: | Zentrum für Infektionsforschung (ZINF): Nachwuchsgruppe 2 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Tag: | gastrointestinal disease; helicobacter; inflammatory bowel disease; microbiota; norovirus; organoid culture; rotavirus; salmonella |
Release Date: | 2017/09/28 |
Note: | This is the accepted version of the following article: Bartfeld, Sina, Modeling infectious diseases and host-microbe interactions in gastrointestinal organoids, Developmental Biology, 2016, 420, 2, 262-270. http://dx.doi.org/10.1016/j.ydbio.2016.09.014 |
Licence (German): | CC BY-NC-ND: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell, Keine Bearbeitung |