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Leaky gut as a potential culprit for the paradoxical dysglycemic response to gastric bypass-associated ileal microbiota
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-234085
- Altered host-intestinal microbiota interactions are increasingly implicated in the metabolic benefits of Roux-en-Y gastric bypass (RYGB) surgery. We previously found, however, that RYGB-associated ileal microbiota can paradoxically impair host glycemic control when transferred to germ-free mice. Here we present complementary evidence suggesting that this could be due to the heightened development of systemic endotoxemia. Consistently, application of ileal content from RYGB-treated compared with sham-operated rats onto Caco-2 cell monolayersAltered host-intestinal microbiota interactions are increasingly implicated in the metabolic benefits of Roux-en-Y gastric bypass (RYGB) surgery. We previously found, however, that RYGB-associated ileal microbiota can paradoxically impair host glycemic control when transferred to germ-free mice. Here we present complementary evidence suggesting that this could be due to the heightened development of systemic endotoxemia. Consistently, application of ileal content from RYGB-treated compared with sham-operated rats onto Caco-2 cell monolayers compromised barrier function and decreased expression of the barrier-stabilizing proteins claudin-4 and desmoglein-2. Our findings raise the possibility that RYGB-associated ileal microbiota produce and release soluble metabolites which locally increase intestinal permeability to promote systemic endotoxemia-induced insulin resistance, with potential implications for the treatment of RYGB patients who eventually relapse onto type 2 diabetes.…
Autor(en): | Mohammed K. Hankir, Florian Seyfried, Isabel N. Schellinger, Nicolas Schlegel, Tulika Arora |
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URN: | urn:nbn:de:bvb:20-opus-234085 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I) |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Metabolites |
ISSN: | 2218-1989 |
Erscheinungsjahr: | 2021 |
Band / Jahrgang: | 11 |
Heft / Ausgabe: | 3 |
Aufsatznummer: | 153 |
Originalveröffentlichung / Quelle: | Metabolites (2021) 11:3, 153. https://doi.org/10.3390/metabo11030153 |
DOI: | https://doi.org/10.3390/metabo11030153 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Freie Schlagwort(e): | Roux-en-Y gastric bypass surgery; intestinal epithelial barrier; intestinal microbiota; systemic endotoxemia; type 2 diabetes |
Datum der Freischaltung: | 12.08.2022 |
Datum der Erstveröffentlichung: | 08.03.2021 |
Lizenz (Deutsch): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |