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Optomotor-blind negatively regulates Drosophila eye development by blocking Jak/STAT signaling

Please always quote using this URN: urn:nbn:de:bvb:20-opus-143577
  • Organ formation requires a delicate balance of positive and negative regulators. In Drosophila eye development, wingless (wg) is expressed at the lateral margins of the eye disc and serves to block retinal development. The T-box gene optomotor-blind (omb) is expressed in a similar pattern and is regulated by Wg. Omb mediates part of Wg activity in blocking eye development. Omb exerts its function primarily by blocking cell proliferation. These effects occur predominantly in the ventral margin. Our results suggest that the primary effect of OmbOrgan formation requires a delicate balance of positive and negative regulators. In Drosophila eye development, wingless (wg) is expressed at the lateral margins of the eye disc and serves to block retinal development. The T-box gene optomotor-blind (omb) is expressed in a similar pattern and is regulated by Wg. Omb mediates part of Wg activity in blocking eye development. Omb exerts its function primarily by blocking cell proliferation. These effects occur predominantly in the ventral margin. Our results suggest that the primary effect of Omb is the blocking of Jak/STAT signaling by repressing transcription of upd which encodes the Jak receptor ligand Unpaired.show moreshow less

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Metadaten
Author: Yu-Chen Tsai, Stefan Grimm, Ju-Lan Chao, Shih-Chin Wang, Kerstin Hofmeyer, Jie Shen, Fred Eichinger, Theoni Michalopoulou, Chi-Kuang Yao, Chih-Hsuan Chang, Shih-Han Lin, Y. Henry Sun, Gert O. Pflugfelder
URN:urn:nbn:de:bvb:20-opus-143577
Document Type:Journal article
Faculties:Fakultät für Biologie / Theodor-Boveri-Institut für Biowissenschaften
Language:English
Parent Title (English):PLoS ONE
Year of Completion:2015
Volume:10
Issue:3
Pagenumber:e0120236
Source:PLoS ONE 10(3): e0120236 (2015). DOI: 10.1371/journal.pone.0120236
DOI:https://doi.org/10.1371/journal.pone.0120236
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Tag:acts downstream; cell fate; compartment boundary; compound eye; gene expression; glial cells; imaginal disk; morphogenetic furrow progression; reporter gene; retinal differentiation
Release Date:2018/05/22
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International